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Advances for Treatment of Knee OC Defects

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Osteochondral Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1059))

Abstract

Osteochondral (OC) defects are prevalent among young adults and are notorious for being unable to heal. Although they are traumatic in nature, they often develop silently. Detection of many OC defects is challenging, despite the criticality of early care. Current repair approaches face limitations and cannot provide regenerative or long-standing solution. Clinicians and researchers are working together in order to develop approaches that can regenerate the damaged tissues and protect the joint from developing osteoarthritis. The current concepts of tissue engineering and regenerative medicine, which have brought many promising applications to OC management, are overviewed herein. We will also review the types of stem cells that aim to provide sustainable cell sources overcoming the limitation of autologous chondrocyte-based applications. The various scaffolding materials that can be used as extracellular matrix mimetic and having functional properties similar to the OC unit are also discussed.

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Authors and Affiliations

  1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Marta Ondrésik, J. Miguel Oliveira & Rui L. Reis

  2. ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Marta Ondrésik, J. Miguel Oliveira & Rui L. Reis

  3. The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Barco, Guimarães, Portugal

    J. Miguel Oliveira & Rui L. Reis

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  1. Marta Ondrésik
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  2. J. Miguel Oliveira
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  3. Rui L. Reis
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  1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    J. Miguel Oliveira

  2. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Sandra Pina

  3. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    Rui L. Reis

  4. Polymeric Nanomaterials and Biomaterials Department, Institute of Polymer Science and Technology, Spanish Council for Scientific Research (CSIC), Madrid, Spain

    Julio San Roman

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Ondrésik, M., Oliveira, J.M., Reis, R.L. (2018). Advances for Treatment of Knee OC Defects. In: Oliveira, J., Pina, S., Reis, R., San Roman, J. (eds) Osteochondral Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1059. Springer, Cham. https://doi.org/10.1007/978-3-319-76735-2_1

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