Skip to main content

Digital Medicines to Measure Drug Ingestion Adherence

  • Chapter
  • First Online:
Drug Adherence in Hypertension and Cardiovascular Protection

Abstract

Proteus Discover, a new digital medicine offering, provides a direct measure of medication ingestion adherence. The offering gives patients feedback on their performance via a mobile device application and allows providers to review patients’ medication adherence and activity. Digital medicines have been shown through clinical studies and real-world use to provide benefits for patients with diabetes and hypertension, as well as other diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rohatagi S, Profit D, Hatch A, Zhao C, Docherty JP, Peters-Strickland TS. Optimization of a digital medicine system in psychiatry. J Clin Psychiatry. 2016;77(9):e1101–7. https://doi.org/10.4088/JCP.16m10693.

    Article  PubMed  Google Scholar 

  2. Choudhry NK, Krumme AA, Ercole PM, Girdish C, Tong AY, Khan NF, Brennan TA, Matlin OS, Shrank WH, Franklin JM. Effect of reminder devices on medication adherence: the REMIND randomized clinical trial. JAMA Intern Med. 2017;177(5):624. https://doi.org/10.1001/jamainternmed.2016.9627.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Choudhry NK, Krumme AA, Ercole PM, Girdish C, Isaman DL, Matlin OS, Brennan TA, Shrank WH, Franklin JM. Rationale and design of the randomized evaluation to measure improvements in non-adherence from low-cost devices (REMIND) trial. Contemp Clin Trials. 2015;43:53–9. https://doi.org/10.1016/j.cct.2015.05.006.

    Article  PubMed  Google Scholar 

  4. Kahneman D. Thinking, fast and slow. 1st ed. New York: Farrar, Straus and Giroux; 2011.

    Google Scholar 

  5. Hibbard JH, Greene J, Overton V. Patients with lower activation associated with higher costs; delivery systems should know their patients’ “scores”. Health Aff Proj Hope. 2013;32(2):216–22. https://doi.org/10.1377/hlthaff.2012.1064.

    Article  Google Scholar 

  6. Remmers C, Hibbard J, Mosen DM, Wagenfield M, Hoye RE, Jones C. Is patient activation associated with future health outcomes and healthcare utilization among patients with diabetes? J Ambulatory Care Manage. 2009;32(4):320–7. https://doi.org/10.1097/JAC.0b013e3181ba6e77.

    Article  PubMed  Google Scholar 

  7. DiCarlo L, Moon G, Intondi A, Duck R, Frank J, Hafazi H, Behzadi Y, Robertson T, Costello B, Savage G, Zdeblick M. A digital health solution for using and managing medications: wirelessly observed therapy. IEEE Pulse. 2012;3(5):23–6. https://doi.org/10.1109/MPUL.2012.2205777.

    Article  PubMed  Google Scholar 

  8. Hafezi H, Robertson TL, Moon GD, Au-Yeung K-Y, Zdeblick MJ, Savage GM. An ingestible sensor for measuring medication adherence. IEEE Trans Biomed Eng. 2015;62(1):99–109. https://doi.org/10.1109/TBME.2014.2341272.

    Article  PubMed  Google Scholar 

  9. Proteus digital health feedback device, instructions for use. Redwood City, CA: Proteus(r) Digital Health, Inc.; 2016.

    Google Scholar 

  10. Godbehere P, Wareing P. Hypertension assessment and management: role for digital medicine. J Clin Hypertens (Greenwich). 2014;16(3):235. https://doi.org/10.1111/jch.12246.

    Article  Google Scholar 

  11. Noble K, Brown K, Medina M, Alvarez F, Young J, Leadley S, Kim Y, DiCarlo L. Medication adherence and activity patterns underlying uncontrolled hypertension: assessment and recommendations by practicing pharmacists using digital health care. J Am Pharm Assoc. 2016;56(3):310–5. https://doi.org/10.1016/j.japh.2016.01.005.

    Article  Google Scholar 

  12. Naik R, Macey N, West RJ, Godbehere P, Thurston S, Fox R, Xiang W, Kim YA, Singh I, Leadley S, DiCarlo LA. First use of an ingestible sensor to manage uncontrolled blood pressure in primary practice: the UK hypertension registry. J Community Med Health Educ. 2017;7(1). https://doi.org/10.4172/2161-0711.1000506.

  13. Frias J, Virdi N, Raja P, Kim Y, Savage G, Osterberg L. Effectiveness of digital medicines to improve clinical outcomes in patients with uncontrolled hypertension and type 2 diabetes: Prospective, Open-Label, Cluster-Randomized Pilot Clinical Trial. J Med Internet Res 2017;19(7):e246. DOI:10.2196/jmir.7833.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Pidermann B, Park H, Bijlani A, Truscott A, Travis E, Purvance C. The first real-world clinical and health economic outcomes of a digital health offering in a patient population with cardiovascular and metabolic chronic diseases. J Manag Care Spec Pharm 2017;23(3-a):S68.

    Google Scholar 

  15. Pinsky BW, Takemoto SK, Lentine KL, Burroughs TE, Schnitzler MA, Salvalaggio PR. Transplant outcomes and economic costs associated with patient noncompliance to immunosuppression. Am J Transplant. 2009;9(11):2597–606. https://doi.org/10.1111/j.1600-6143.2009.02798.x.

    Article  PubMed  CAS  Google Scholar 

  16. Zullig LL, Peterson ED, Bosworth HB. Ingredients of successful interventions to improve medication adherence. JAMA. 2013;310(24):2611–2. https://doi.org/10.1001/jama.2013.282818.

    Article  CAS  PubMed  Google Scholar 

  17. Lin S, Melendez-Torres GJ. Systematic review of risk factors for nonadherence to TB treatment in immigrant populations. Trans R Soc Trop Med Hyg. 2016;110(5):268–80. https://doi.org/10.1093/trstmh/trw025.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Lee WC, Balu S, Cobden D, Joshi AV, Pashos CL. Prevalence and economic consequences of medication adherence in diabetes: a systematic literature review. Manag Care Interface. 2006;19(7):31–41.

    PubMed  Google Scholar 

  19. Claborn KR, Meier E, Miller MB, Leffingwell TR. A systematic review of treatment fatigue among HIV-infected patients prescribed antiretroviral therapy. Psychol Health Med. 2015;20(3):255–65. https://doi.org/10.1080/13548506.2014.945601.

    Article  PubMed  Google Scholar 

  20. Ascher-Svanum H, Faries DE, Zhu B, Ernst FR, Swartz MS, Swanson JW. Medication adherence and long-term functional outcomes in the treatment of schizophrenia in usual care. J Clin Psychiatry. 2006;67(3):453–60.

    Article  PubMed  Google Scholar 

  21. Blaschke TF, Osterberg L, Vrijens B, Urquhart J. Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories. Annu Rev Pharmacol Toxicol. 2012;52:275–301. https://doi.org/10.1146/annurev-pharmtox-011711-113247.

    Article  PubMed  CAS  Google Scholar 

  22. Kane JM, Perlis RH, DiCarlo LA, Au-Yeung K, Duong J, Petrides G. First experience with a wireless system incorporating physiologic assessments and direct confirmation of digital tablet ingestions in ambulatory patients with schizophrenia or bipolar disorder. J Clin Psychiatry. 2013;74(6):e533–40. https://doi.org/10.4088/JCP.12m08222.

    Article  PubMed  Google Scholar 

  23. Belknap R, Weis S, Brookens A, Au-Yeung KY, Moon G, DiCarlo L, Reves R. Feasibility of an ingestible sensor-based system for monitoring adherence to tuberculosis therapy. PLoS One. 2013;8(1):e53373. https://doi.org/10.1371/journal.pone.0053373.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  24. Wirelessly Observed Therapy (WOT): a new paradigm in TB therapy monitoring | CROI conference. http://www.croiconference.org/sessions/wirelessly-observed-therapy-wot-new-paradigm-tb-therapy-monitoring. Accessed 25 Apr 2017.

  25. Bonacini M, Kim YA, Reichert M, Travis E, Virdi N, Raja P, Savage G. Tu1659 a new digital health feedback offering to keep patients adherent to oral hepatitis C therapy. Gastroenterology. 2016;150(4):S1159. https://doi.org/10.1016/S0016-5085(16)33916-6.

    Article  Google Scholar 

  26. Corris PA, Day M, Gibiansky M, Kim YA, DiCarlo L. A pilot study of digital feedback to guide therapeutic decisions in pulmonary hypertension. Eur Respir J. 2016;48(Suppl 60):PA2407.

    Google Scholar 

  27. Measuring and monitoring adherence to ART with pill ingestible sensor system—full text view. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02797262. Accessed 9 May 2017.

  28. Digital health feedback system for longitudinal measurement of medication adherence during initial ARV therapy—full text view. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02800655. Accessed 9 May 2017.

  29. Feasibility of an ingestible sensor system to measure PrEP adherence in YMSM—full text view. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02891720. Accessed 9 May 2017.

Download references

Acknowledgements

The author would like to acknowledge the following persons for their editorial support: Scooter Plowman, Betsy Klein, Praveen Raja, Melody Tran, George Savage, Lorenzo DiCarlo, Andrew Thompson, Maneesh Gupta, David O’Reilly, Manny Severino, and Lacey Kim.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Naunihal S. Virdi M.D., F.A.C.P. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Virdi, N.S. (2018). Digital Medicines to Measure Drug Ingestion Adherence. In: Burnier, M. (eds) Drug Adherence in Hypertension and Cardiovascular Protection. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-76593-8_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-76593-8_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-76592-1

  • Online ISBN: 978-3-319-76593-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics