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MOSS: A Patient-Centered Approach

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Metastatic Spine Disease

Abstract

The treatment of metastatic spinal cord compression (MSCC) is complex and varies from patient to patient. There are numerous treatment algorithms and mnemonics designed to reduce uncertainty in treatment planning and thereby expedite treatment. There are also prospective, randomized studies that are similarly designed to simplify planning and thereby optimize treatment in these patients. We have found, however, that some of these methods of planning treatment oversimplify what is in reality a complex, ever-changing clinical scenario. These various methods also place a greater emphasis on the degree of the spinal cord compression than on more patient-centered variables. We have developed a mnemonic that we believe will expedite decision-making, and more importantly, will do so in the context of patient-specific variables. We believe that only such a patient-centered approach to treatment planning can reliably ensure an optimal outcome in the patient with MSCC. The mnemonic, MOSS, stands for medical/mental, oncologic, stenosis, and stability. This memory aid requires the practitioner to first assess the patient’s medical and mental condition, and their oncologic diagnosis, prognosis, and stage, before gauging the degree of spinal cord compression, neurologic loss, or spinal instability. Specifically, treatment in a patient in a poor mental and medical state whose cancer is very advanced should likely be different from that in the patient in a better mental and medical state whose compression may be very similar to that in the sicker patient. MOSS also requires the joint participation of the multidisciplinary team in both the assessment phase and the selection of adjuvant and up-to-date technology for treatment. The old saying that a rolling stone gathers no MOSS applies in a more modern sense to those who are willing to consider and adopt new ideas and to abandon approaches to the treatment of MSCC that emphasize surgical intervention rather than evaluation of the patient and current medical and surgical treatment options. The treatment for MSCC in its various manifestations is continuously changing, and patient-centered decision-making, such as that afforded by MOSS, will help ensure that the best of these new techniques and technology are used in those patients in the best position to benefit from them.

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References

  1. Dunn RC, Kelly WA, Wohns RNW, Howe JF. Spinal epidural neoplasia. J Neurosurg. 1980;52(1):47–51. https://doi.org/10.3171/jns.1980.52.1.0047.

    Article  PubMed  Google Scholar 

  2. Gilbert RW, Kim J-H, Posner JB. Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol. 1978;3(1):40–51. https://doi.org/10.1002/ana.410030107.

    Article  CAS  PubMed  Google Scholar 

  3. Livingston KE, Perrin RG. The neurosurgical management of spinal metastases causing cord and cauda equina compression. J Neurosurg. 1978;49(6):839–43. https://doi.org/10.3171/jns.1978.49.6.0839.

    Article  PubMed  CAS  Google Scholar 

  4. Young RF, Post EM, King GA. Treatment of spinal epidural metastases. J Neurosurg. 1980;53(6):741–8. https://doi.org/10.3171/jns.1980.53.6.0741.

    Article  CAS  PubMed  Google Scholar 

  5. Rompe JD, Hopf CG, Eysel P. Outcome after palliative posterior surgery for metastatic disease of the spine—evaluation of 106 consecutive patients after decompression and stabilisation with the Cotrel-Dubousset instrumentation. Arch Orthop Trauma Surg. 1999;119(7–8):394–400.

    Article  CAS  PubMed  Google Scholar 

  6. Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet. 2005;366(9486):643–8. https://doi.org/10.1016/s0140-6736(05)66954-1.

    Article  PubMed  Google Scholar 

  7. Cassady JR, Sagerman RH, Chang CH. Radiation therapy for lymphoma of the spinal canal. Radiology. 1967;89(2):313–5. https://doi.org/10.1148/89.2.313.

    Article  Google Scholar 

  8. Friedman M, Kim TH, Panahon AM. Spinal cord compression in malignant lymphoma—treatment and results. Cancer. 1976;37(3):1485–91. https://doi.org/10.1002/1097-0142(197603)37:3<1485::aid-cncr2820370334>3.0.co;2-l.

    Article  CAS  PubMed  Google Scholar 

  9. Khan FR, Glicksman AS, Chu FCH, Nickson JJ. Treatment by radiotherapy of spinal cord compression due to extradural metastases. Radiology. 1967;89(3):495–500. https://doi.org/10.1148/89.3.495.

    Article  CAS  PubMed  Google Scholar 

  10. Martin WE. Radiation therapy for paraplegia due to multiple myeloma. JAMA. 1965;191(3):247. https://doi.org/10.1001/jama.1965.03080030091020.

    Article  CAS  PubMed  Google Scholar 

  11. Mones RJ, Dozier D, Berrett A. Analysis of medical treatment of malignant extradural spinal cord tumors. Cancer. 1966;19(12):1842–53. https://doi.org/10.1002/1097-0142(196612)19:12<1842::aid-cncr2820191212>3.0.co;2-v.

    Article  CAS  PubMed  Google Scholar 

  12. Murphy WT, Bilge N. Compression of the spinal cord in patients with malignant lymphoma. Radiology. 1964;82(3):495–501. https://doi.org/10.1148/82.3.495.

    Article  CAS  PubMed  Google Scholar 

  13. Raichle ME, Posner JB. The treatment of extradural spinal cord compression. Neurology. 1970;20(4):391.

    Article  CAS  PubMed  Google Scholar 

  14. Rubin P, Miller G. Extradural spinal cord compression by tumor. Radiology. 1969;93(6):1243–8. https://doi.org/10.1148/93.6.1243.

    Article  CAS  PubMed  Google Scholar 

  15. Rubin P, Mayer E, Poulter C. Part II: high daily dose experience without laminectomy. Radiology. 1969;93(6):1248–60. https://doi.org/10.1148/93.6.1248.

    Article  CAS  PubMed  Google Scholar 

  16. Chi JH, Gokaslan Z, McCormick P, Tibbs PA, Kryscio RJ, Patchell RA. Selecting treatment for patients with malignant epidural spinal cord compression—does age matter? Spine. 2009;34(5):431–5. https://doi.org/10.1097/brs.0b013e318193a25b.

    Article  PubMed  Google Scholar 

  17. George R, Jeba J, Ramkumar G, Chacko AG, Leng M, Tharyan P. Interventions for the treatment of metastatic extradural spinal cord compression in adults. Cochrane Database Syst Rev. Wiley; 2008.

    Google Scholar 

  18. Laufer I, Rubin DG, Lis E, Cox BW, Stubblefield MD, Yamada Y, et al. The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist. 2013;18(6):744–51. https://doi.org/10.1634/theoncologist.2012-0293.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, et al. Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine. 2010;13(3):324–8. https://doi.org/10.3171/2010.3.spine09459.

    Article  PubMed  Google Scholar 

  20. Lim ZD, Mahajan A, Weinberg J, Tannir NM. Outcome of patients with renal cell carcinoma metastatic to the brain treated with sunitinib without local therapy. Am J Clin Oncol. 2013;36(3):258–60. https://doi.org/10.1097/coc.0b013e3182467b9a.

    Article  CAS  PubMed  Google Scholar 

  21. Rousseau B, Kempf E, Desamericq G, Boissier E, Chaubet-Houdu M, Joly C, et al. First-line antiangiogenics for metastatic renal cell carcinoma: a systematic review and network meta-analysis. Crit Rev Oncol Hematol. 2016;107:44–53. https://doi.org/10.1016/j.critrevonc.2016.08.012.

    Article  PubMed  Google Scholar 

  22. Gerszten PC, Mendel E, Yamada Y. Radiotherapy and radiosurgery for metastatic spine disease. Spine. 2009;34(22 Suppl):S78–92. https://doi.org/10.1097/brs.0b013e3181b8b6f5.

    Article  PubMed  Google Scholar 

  23. Gerszten PC, Burton SA, Ozhasoglu C, Welch WC. Radiosurgery for spinal metastases. Spine. 2007;32(2):193–9. https://doi.org/10.1097/01.brs.0000251863.76595.a2.

    Article  PubMed  Google Scholar 

  24. Ryu S, Rock J, Jain R, Lu M, Anderson J, Jin J-Y, et al. Radiosurgical decompression of metastatic epidural compression. Cancer. 2010;116(9):2250–7. https://doi.org/10.1002/cncr.24993.

    Article  PubMed  Google Scholar 

  25. Ryu S, Rock J, Rosenblum M, Kim JH. Patterns of failure after single-dose radiosurgery for spinal metastasis. J Neurosurg. 2004;101(Suppl 3):402–5. https://doi.org/10.3171/jns.2004.101.supplement3.0402.

  26. Gerszten PC, Burton SA, Ozhasoglu C, Vogel WJ, Welch WC, Baar J, et al. Stereotactic radiosurgery for spinal metastases from renal cell carcinoma. J Neurosurg Spine. 2005;3(4):288–95. https://doi.org/10.3171/spi.2005.3.4.0288.

    Article  PubMed  Google Scholar 

  27. Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, et al. A novel classification system for spinal instability in neoplastic disease. Spine. 2010;35(22):E1221–E9. https://doi.org/10.1097/brs.0b013e3181e16ae2.

    Article  PubMed  Google Scholar 

  28. Kris MG, Natale RB, Herbst RS, Lynch JTJ, Prager D, Belani CP, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non–small cell lung cancer. JAMA. 2003;290(16):2149. https://doi.org/10.1001/jama.290.16.2149.

    Article  PubMed  CAS  Google Scholar 

  29. Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012;13(3):239–46. https://doi.org/10.1016/s1470-2045(11)70393-x.

    Article  CAS  PubMed  Google Scholar 

  30. Paez JG. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497–500. https://doi.org/10.1126/science.1099314.

    Article  CAS  PubMed  Google Scholar 

  31. Berenson J, Pflugmacher R, Jarzem P, Zonder J, Schechtman K, Tillman JB, et al. Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial. Lancet Oncol. 2011;12(3):225–35. https://doi.org/10.1016/s1470-2045(11)70008-0.

    Article  PubMed  Google Scholar 

  32. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649–56. https://doi.org/10.1097/00000421-198212000-00014.

    Article  PubMed  CAS  Google Scholar 

  33. Conill C, Verger E, Salamero M. Performance status assessment in cancer patients. Cancer. 1990;65(8):1864–6. https://doi.org/10.1002/1097-0142(19900415)65:8<1864::aid-cncr2820650832>3.0.co;2-u.

    Article  PubMed  CAS  Google Scholar 

  34. Maranzano E, Latini P. Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial. Int J Radiat Oncol Biol Phys. 1995;32(4):959–67. https://doi.org/10.1016/0360-3016(95)00572-g.

    Article  CAS  PubMed  Google Scholar 

  35. Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine. 2005;30(19):2186–91. https://doi.org/10.1097/01.brs.0000180401.06919.a5.

    Article  PubMed  Google Scholar 

  36. Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine. 2001;26(3):298–306. https://doi.org/10.1097/00007632-200102010-00016.

    Article  PubMed  CAS  Google Scholar 

  37. Panjabi MM. Clinical spinal instability and low back pain. J Electromyogr Kinesiol. 2003;13(4):371–9. https://doi.org/10.1016/s1050-6411(03)00044-0.

    Article  PubMed  Google Scholar 

  38. Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. In: Tumors TRESftPoMS, editor. Spine (Phila Pa 1976): Ovid Technologies (Wolters Kluwer Health); 2005. p. Table 2. Revised Evaluation System for the Prognosis of Metastatic Spine Tumors.

    Google Scholar 

  39. Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. In: metastases FSsfs, editor. Spine: Ovid Technologies (Wolters Kluwer Health); 2001. p. Figure 1. Surgical strategy for spinal metastases.

    Article  CAS  PubMed  Google Scholar 

  40. Wang JC, Boland P, Mitra N, Yamada Y, Lis E, Stubblefield M, et al. Single-stage posterolateral transpedicular approach for resection of epidural metastatic spine tumors involving the vertebral body with circumferential reconstruction: results in 140 patients. J Neurosurg Spine. 2004;1(3):287–98. Figure 1.

    Article  PubMed  Google Scholar 

  41. Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, et al. A novel classification system for spinal instability in neoplastic disease. Spine: Ovid Technologies (Wolters Kluwer Health); 2010. p. Table 1 The SINS classification according to Fisher et al.

    Google Scholar 

  42. Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH et al. A novel classification system for spinal instability in neoplastic disease. Spine: Ovid Technologies (Wolters Kluwer Health); 2010. p. Table 2 SINS scores organized as a total score, three-clinical categories, and binary scale with their corresponding levels of stability where surgical consultation is recommended for a total score >7.

    Google Scholar 

  43. Yamada Y, Bilsky MH. IAEA Singapore SBRT Symposium. 2013.

    Google Scholar 

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Marco, R.A.W., Brindise, J., Dong, D. (2018). MOSS: A Patient-Centered Approach. In: Marco, R. (eds) Metastatic Spine Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-76252-4_1

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  • DOI: https://doi.org/10.1007/978-3-319-76252-4_1

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