Skip to main content

Manic and Bipolar Syndromes

  • Chapter
  • First Online:
Neuropsychodynamic Psychiatry
  • 921 Accesses

Abstract

Patients with bipolar disorders show numerous neuropsychological impairments, not only during depressive and manic episodes but also after remission of symptoms. These dysfunctions are associated with structural and functional changes in cortical and limbic brain regions and have a profound impact on patients’ psychosocial functioning. This chapter gives an overview on relevant neuroscientific and neuropsychological findings in bipolar disorders. Furthermore, the personality structure and the interpersonal relationships of bipolar patients are taken into account.

In a neuropsychodynamic perspective, the hypernomic und ambiguity-intolerant behaviour of bipolar patients may be looked upon as an attempt to cope with an impending threat of a collapsing self-worth regulation and the shame which results from the experience of mania. In case of an instability of the self-image, a narcissistic slight or a disappointment (with an impairment of the ideal self) may induce a regression to the precursor stages of the ideal self (regressive activation of the grandiose self) or an actualization of other intrapsychic elements of the self-worth regulation and their precursors (e.g. complete submission to the claims of a rigid, rigorous superego). This may be interpreted as an attempt to cope with the narcissistic dysbalance and the danger of a depressive reaction.

The conceptualization of manic symptoms as mood modulators has important implications for the understanding and treatment of mania. The confrontation with the “temptation of mania” is of fundamental importance in the treatment of mania. The effectiveness of the drug treatment and the compliance of the patients depend on their attitude to mania essentially. In this context mania may not only be comprehended as the experience of a fatal disorder but also as a condition which is intended and desired. The neuropsychodynamic view of manic symptoms as mood modulators constitutes an important basis for the dialogue with the patients and provides them with a better understanding of their painful renunciation of the manic sense of euphoria.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Angst J. Zur Ätiologie und Nosologie endogener depressiver Psychosen. Berlin: Springer; 1966.

    Book  Google Scholar 

  • Arts B, et al. Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med. 2009;39(3):525.

    Article  Google Scholar 

  • Bearden CE, et al. The impact of neurocognitive impairment on occupational recovery of clinically stable patients with bipolar disorder: a prospective study. Bipolar Disord. 2011;13(4):323–33.

    Article  Google Scholar 

  • Beblo T, et al. Specifying the neuropsychology of affective disorders: clinical, demographic and neurobiological factors. Neuropsychol Rev. 2011;21(4):337–59.

    Article  Google Scholar 

  • Benedetti FP, et al. Disruption of white matter integrity in bipolar depression as a possible structural marker of illness. Biol Psychiatry. 2011;69(4):309–17.

    Article  Google Scholar 

  • Bleuler E. Die Probleme der Schizoidie und der Syntonie. Zeitschrift für die gesamte Neurologie und Psychiatrie. 1922;78(1):373–99.

    Article  Google Scholar 

  • Blumberg HP, et al. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry. 2003;60(6):601–9.

    Article  Google Scholar 

  • Böker H. Selbstbild und Objektbeziehungen bei Depressionen: Untersuchungen mit der Repertory Grid-Technik und dem Giessen-Test an 139 PatientInnen mit depressiven Erkrankungen. Monographien aus dem Gesamtgebiete der Psychiatrie. Darmstadt: Steinkopff-Springer; 1999.

    Book  Google Scholar 

  • Böker H. Psychotherapie bei bipolaren affektiven Störungen. In: Böker H, Hell D, editors. Therapie der affektiven Störungen. Psychosoziale und neurobiologische Perspektiven. Stuttgart: Schattauer; 2002. p. 230–45.

    Google Scholar 

  • Bonnin CM, et al. Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study. J Affect Disord. 2010;121(1–2):156–60.

    Article  CAS  Google Scholar 

  • Bora E, et al. Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord. 2009;113(1–2):1–20.

    Article  Google Scholar 

  • Carlson GA, Bromert EJ, Sievers S. Phenomenology and outcome of subjects with early- and adult-onset psychotic mania. Am J Psychiatry. 2000;127:213–9.

    Article  Google Scholar 

  • Chen CH, et al. A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord. 2011;13(1):1–15.

    Article  CAS  Google Scholar 

  • Christensen H, et al. A quantitative review of cognitive deficits in depression and Alzheimer-type dementia. J Int Neuropsychol Soc. 1997;3(6):631–51.

    CAS  PubMed  Google Scholar 

  • Clark L, Goodwin GM. State- and trait-related deficits in sustained attention in bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2004;254(2):61–8.

    Article  Google Scholar 

  • Cotter D, et al. The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia. Biol Psychiatry. 2002;51(5):377–86.

    Article  CAS  Google Scholar 

  • Cousins DA, et al. Lithium, gray matter, and magnetic resonance imaging signal. Biol Psychiatry. 2013;73(7):652–7.

    Article  CAS  Google Scholar 

  • Denicoff KD, Leverich GS, Nolen WA, et al. Validation of the prospective NIMH-life chart-method (NIMH-LCM-p) for longitudinal assessment of bipolar illness. Psychol Med. 2000;30:1391–7.

    Article  CAS  Google Scholar 

  • Elia C. Der psychodynamische Zugang zum manischen Patienten. In: Benedetti C, et al., editors. Psychosentherapie. Stuttgart: Hippokrates; 1983. p. 263–317.

    Google Scholar 

  • Gabbard GO. Psychodynamic psychiatry in clinical practice. 5th ed. Washington DC: Amer Psychiatric Publ; 2014.

    Google Scholar 

  • Ghaemi SN, Stoll SL, Pope HG. Lack of insight in bipolar disorder: the acute manic episode. J Nerv Ment Dis. 1995;183:464–7.

    Article  CAS  Google Scholar 

  • Goodwin FK, Jamison KR. Manic-depressive illness. Oxford, NY: Oxford University Press; 1990.

    Google Scholar 

  • van Gorp WG, et al. Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence - a preliminary study. Arch Gen Psychiatry. 1998;55(1):41–6.

    Article  Google Scholar 

  • Gualtieri CT, Morgan DW. The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: an unaccounted source of variance in clinical trials. J Clin Psychiatry. 2008;69(7):1122–30.

    Article  Google Scholar 

  • Hartwich P, Pfeffer F Die bipolare Psychodynamik in der Gruppenpsychotherapie. Pilotstudie zur Wirksamkeit. Vortrag auf dem Kongress “Bipolare Störungen” am 21.09.2007 an der Ruhruniversität Bochum, published in Hartwich P, Grube M (2015) Psychotherapie bei Psychosen, Kap Größenwahn und Scham. Heidelberg: Springer; 2007. p. 117–26.

    Google Scholar 

  • Himmighoffen H. Selbstwertproblematik und psychosoziale Bewältigungsstrategien bei PatientInnen mit bipolaren affektiven Psychosen. In: Böker H, editor. Depression, Manie und schizoaffektive Psychosen. Psychodynamische Theorien, einzelfallorientierte Forschung und Psychotherapie. 3rd ed. Giessen: Psychosozial-Verlag; 2000. p. 227–43.

    Google Scholar 

  • Hollon SD, Ponniah K. A review of empirically supported psychological therapies for mood disorders in adults. Depress Anxiety. 2010;27:891–932.

    Article  Google Scholar 

  • Hsiao YL, et al. Neuropsychological functions in patients with bipolar I and bipolar II disorder. Bipolar Disord. 2009;11(5):547–54.

    Article  Google Scholar 

  • Jamison KR. An unquiet mind. New York: Vintage Books; 1995.

    Google Scholar 

  • Karnath HO, Sturm W. Störungen von Planungs- und Kontrollfunktionen. Klinische Neuropsychologie. H. W. P. K. Stuttgart: Thieme; 2002.

    Google Scholar 

  • Kempton MJ, et al. Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder. Arch Gen Psychiatry. 2008;65(9):1017–32.

    Article  Google Scholar 

  • Kipp J, Stolzenburg H-J. Stimmungsmodulation und die Psychodynamik der Manie. Psyche – Zeitschrift für Psychoanalyse. 2000;54:544–66.

    Google Scholar 

  • Kraus A. Neuere psychopathologische Konzepte zur Persönlichkeit manisch-depressiver. In: Mundt C, Fiedler P, Lang H, Kraus A, editors. Depressionskonzepte heute. Berlin: Springer; 1991.

    Google Scholar 

  • Kretschmer E. Körperbau und Charakter. 26th edition, 1921. Berlin, Heidelberg, New York; 1977.

    Google Scholar 

  • Kröber H-L. Akute Krisen bei Manien. Nervenheilkunde. 1992;11:1–3.

    Google Scholar 

  • Kröber H-L. Bipolare Patienten im Intervall: Persönlichkeitsstörungen und Persönlichkeitswandel. Nervernarzt. 1993;64:318–23.

    Google Scholar 

  • Kurtz MM, Gerraty RT. A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state. Neuropsychology. 2009;23(5):551–62.

    Article  Google Scholar 

  • Leonhard K. Die präpsychotische Temperament bei den monopolaren und bipolaren phasischen Psychosen. Psychiatr Neurol. 1963;146:105–15.

    Article  CAS  Google Scholar 

  • Lezak M. Neuropsychological assessment. Oxford, NY: Oxford University Press; 1995.

    Google Scholar 

  • Lim CS, et al. Longitudinal neuroimaging and neuropsychological changes in bipolar disorder patients: review of the evidence. Neurosci Biobehav Rev. 2013;37(3):418–35.

    Article  Google Scholar 

  • Liu SK, et al. Deficits in sustained attention in schizophrenia and affective disorders: stable versus state-dependent markers. Am J Psychiatry. 2002;159(6):975–82.

    Article  Google Scholar 

  • Lyoo IK, et al. Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: a longitudinal brain imaging study. Neuropsychopharmacology. 2010;35(8):1743–50.

    Article  CAS  Google Scholar 

  • Mann-Wrobel M, et al. Meta-analysis of neuropsychological functioning in euthymic bipolar disorder: an update and investigation of moderator variables. Bipolar Disord. 2011;13(4):334–42.

    Article  Google Scholar 

  • Martinez-Aran A, et al. Functional outcome in bipolar disorder: the role of clinical and cognitive factors. Bipolar Disord. 2007;9(1–2):103–13.

    Article  CAS  Google Scholar 

  • Matussek P, Luks O, Seibt G. Partner relationships of depressives. Psychopathology. 1986;19:143–56.

    Article  CAS  Google Scholar 

  • Mentzos S. Neurotische Konfliktverarbeitung. Frankfurt/M: Fischer; 1984.

    Google Scholar 

  • Mentzos S. Depression und Manie; Psychodynamik und Psychotherapie affektiver Störungen. Göttingen: Vandenhoeck und Ruprecht; 1995.

    Google Scholar 

  • Mentzos S. Lehrbuch der Psychodynamik. Die Funktion der Dysfunktionalität psychischer Störungen. Göttingen: Vandenhoeck & Ruprecht; 2009.

    Google Scholar 

  • Möller HJ. Zur Bedeutung und methodischen Problematik der psychiatrischen Persönlichkeitsforschung: Der “Typus melancholicus” und andere Konzepte zur prämorbiden Persönlichkeit von Patienten mit affektiven Psychosen. In: Marneros A, Phillip M, editors. Persönlichkeit und psychische Erkrankung. Berlin: Springer; 1992. p. 45–65.

    Chapter  Google Scholar 

  • Möller HJ, von Zerssen D. Prämorbide Persönlichkeit von Patienten mit affektiven Psychosen. In: Kiska KP, Lauter H, Meyer J-E, Müller C, Strungren E, editors. Psychiatrie der Gegenwart Band V. Berlin: Springer; 1987. p. 165–79.

    Google Scholar 

  • Ongur D, et al. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A. 1998;95(22):13290–5.

    Article  CAS  Google Scholar 

  • Osher Y, et al. Computerized testing of neurocognitive function in euthymic bipolar patients compared to those with mild cognitive impairment and cognitively healthy controls. Psychother Psychosom. 2011;80(5):298–303.

    Article  CAS  Google Scholar 

  • Paykel ES. Handbook of affective disorders. New York: Guilford; 1995.

    Google Scholar 

  • Perris C. A study of bipolar (manic-depressive) and unipolar recurrent depressive psychosis. Acta Psychiat Scand Suppl. 1966;194:1–89.

    Google Scholar 

  • Phillips ML, Kupfer DJ. Bipolar disorder diagnosis: challenges and future directions. Lancet. 2013;381(9878):1663–71.

    Article  Google Scholar 

  • Phillips ML, et al. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry. 2008;13(9):833–57.

    Article  Google Scholar 

  • Rajkowska G, et al. Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biol Psychiatry. 2001;49(9):741–52.

    Article  CAS  Google Scholar 

  • Robinson LJ, et al. A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord. 2006;93(1–3):105–15.

    Article  Google Scholar 

  • Sartre JP. Being and nothingness. An essay on phemonemological ontology. Translated by Barnes H E Philosophical Library, Inc, New York, L’é’tre et le néant. Essai d’ontologie phénoménologique (1943). Paris: Librairie Gallimard; 1956.

    Google Scholar 

  • Schwarz F. Psychodynamische Psychotherapie bei bipolaren Störungen. Z Psychiatr Psychol Psychother. 2014;62(4):273–81.

    Google Scholar 

  • Simpson SG, Jamison KR. The risk of suicide in patients with bipolar disorders. J Clin Psychiatry. 1999;60(Suppl 2):53–6.

    PubMed  Google Scholar 

  • Söldner M, Matussek P. Kindheitspersönlichkeit und Kindheitserlebnisse bei Depressiven. In: Matussek P, editor. Beiträge zur Psychodynamik endogener Psychosen. Berlin, Heidelberg, New York: Springer; 1990. p. 134–62.

    Chapter  Google Scholar 

  • Strakowski SM, et al. The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disord. 2012;14(4):313–25.

    Article  Google Scholar 

  • Tellenbach H. Melancholie. Zur Problemgeschichte, Typologie, Pathogenese und Klinik. Berlin, Göttingen, Heidelberg: Springer; 1961.

    Google Scholar 

  • Torres IJ, et al. Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis. Acta Psychiatr Scand Suppl. 2007;434:17–26.

    Article  Google Scholar 

  • Townsend J, Altshuler LL. Emotion processing and regulation in bipolar disorder: a review. Bipolar Disord. 2012;14(4):326–39.

    Article  Google Scholar 

  • Versace A, et al. Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biol Psychiatry. 2010;67(5):422–31.

    Article  Google Scholar 

  • Willi J. Die zweier Beziehung. Spannungsursachen – Störungsmuster – Klärungsprozesse – Lösungsmodelle. Hamburg: Rowohlt; 1975.

    Google Scholar 

  • Wirz-Justice A, Quinto C, Cajochen C, Werth E, Hock C. A rapid-cycling bipolar patient treated with long nights, bed rest, and light. Biol Psychiatry. 1999;45(8):1075–7.

    Article  CAS  Google Scholar 

  • Zerssen von D. Premorbid personality and affective psychoses. In: Burrows GD, editor. Handbook of studies on depression. Amsterdam: Excerpta Medica; 1977. p. 79–103.

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Heinz Boeker .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Boeker, H., Grimm, S., Hartwich, P., Northoff, G. (2018). Manic and Bipolar Syndromes. In: Boeker, H., Hartwich, P., Northoff, G. (eds) Neuropsychodynamic Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-319-75112-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-75112-2_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-75111-5

  • Online ISBN: 978-3-319-75112-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics