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Mathematical-Computational Modeling in Behavior’s Study of Repetitive Discharge Neuronal Circuits

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Book cover Theoretical and Applied Aspects of Systems Biology

Part of the book series: Computational Biology ((COBO,volume 27))

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Abstract

Mathematical-computational modeling is a tool that has been widely used in the field of Neuroscience. Despite considerable advances of Physiological Sciences, the neuronal mechanisms involved in the abilities of central nervous system remain obscure, but they can be revealed through modeling. Significant amount of experimental data already available has facilitated the development of models that combine experimentation with theory. They allow to evaluate hypotheses and to seek understanding of neuronal circuit functioning capable of explaining neurophysiological deficits. To model the behavior of repetitive discharge of neuronal circuits, we have used differential equations, graph theory, and other mathematical methods. Through computational simulations, using programs developed in C and C ++ language and neurophysiological data obtained in the literature, we can test the model’s behavior in face of numerical variations of their parameters, trying to observe their characteristics.

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Authors and Affiliations

  1. Universidade do Estado do Rio de Janeiro, UERJ – Rua São Francisco Xavier, Rio de Janeiro, Brazil

    Celia Martins Cortez, Maria Clicia Stelling de Castro, Vanessa de Freitas Rodrigues, Camila Andrade Kalil & Dilson Silva

Authors
  1. Celia Martins Cortez
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  2. Maria Clicia Stelling de Castro
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  3. Vanessa de Freitas Rodrigues
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  4. Camila Andrade Kalil
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  5. Dilson Silva
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Corresponding author

Correspondence to Maria Clicia Stelling de Castro .

Editor information

Editors and Affiliations

  1. Graduate Program in Computational Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil

    Fabricio Alves Barbosa da Silva

  2. Graduate Program in Computational Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil

    Nicolas Carels

  3. Graduate Program in Computational Biology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil

    Floriano Paes Silva Junior

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Cortez, C.M., de Castro, M.C.S., de Freitas Rodrigues, V., Kalil, C.A., Silva, D. (2018). Mathematical-Computational Modeling in Behavior’s Study of Repetitive Discharge Neuronal Circuits. In: Alves Barbosa da Silva, F., Carels, N., Paes Silva Junior, F. (eds) Theoretical and Applied Aspects of Systems Biology. Computational Biology, vol 27. Springer, Cham. https://doi.org/10.1007/978-3-319-74974-7_13

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  • DOI: https://doi.org/10.1007/978-3-319-74974-7_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-74973-0

  • Online ISBN: 978-3-319-74974-7

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