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Chronic Rhinosinusitis

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Infections of the Ears, Nose, Throat, and Sinuses

Abstract

Chronic rhinosinusitis (CRS) is an inflammatory disease of the sinonasal mucosa. It is likely due to a dysregulated immune response directed against, and also modified by, antigens that are present in the paranasal sinuses. The sinonasal microbial flora in CRS patients differs from the sinonasal flora in individuals without CRS. In CRS patients, microbial antigens may be specific targets of the chronic inflammatory response in the paranasal sinuses and may also serve to nonspecifically stimulate the mucosal immune response. Antibiotics do not appear to be beneficial in CRS except possibly to treat acute exacerbations. This chapter reviews our current understanding of pathophysiology, diagnosis, and treatment of CRS.

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References

  1. Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2 Suppl):S39.

    Google Scholar 

  2. Fokkens WJ, Lund VJ, Mullol J, et al. European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl. 2012;23:1–298.

    Google Scholar 

  3. Orlandi RR, Kingdom TT, Hwang PH, et al. International consensus statement on allergy and rhinology: rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(Suppl 1):S209.

    Google Scholar 

  4. Hoehle LP, Phillips KM, Bergmark RW, et al. Symptoms of chronic rhinosinusitis differentially impact general health-related quality of life. Rhinology. 2016;54(4):316–22.

    Article  CAS  PubMed  Google Scholar 

  5. Phillips KM, Hoehle LP, Bergmark RW, et al. Acute exacerbations mediate quality of life impairment in chronic rhinosinusitis. J Allergy Clin Immunol Pract. 2017;5(2):422–6.

    Article  PubMed  Google Scholar 

  6. Phillips KM, Hoehle LP, Caradonna DS, et al. Association of severity of chronic rhinosinusitis with degree of comorbid asthma control. Ann Allergy Asthma Immunol. 2016;117(6):651–4.

    Article  PubMed  Google Scholar 

  7. DeConde AS, Soler ZM. Chronic rhinosinusitis: epidemiology and burden of disease. Am J Rhinol Allergy. 2016;30(2):134–9.

    Article  PubMed  Google Scholar 

  8. Campbell AP, Phillips KM, Hoehle LP, et al. Depression symptoms and lost productivity in chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2017;118(3):286–9.

    Article  PubMed  Google Scholar 

  9. Caulley L, Thavorn K, Rudmik L, et al. Direct costs of adult chronic rhinosinusitis by using 4 methods of estimation: results of the US Medical Expenditure Panel Survey. J Allergy Clin Immunol. 2015;136(6):1517–22.

    Article  PubMed  Google Scholar 

  10. Smith KA, Orlandi RR, Rudmik L. Cost of adult chronic rhinosinusitis: a systematic review. Laryngoscope. 2015;125(7):1547–56.

    Article  PubMed  Google Scholar 

  11. Bachert C, Pawankar R, Zhang L, et al. ICON: chronic rhinosinusitis. World Allergy Organ J. 2014;7(1):25. eCollection 2014.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Hsu J, Avila PC, Kern RC, et al. Genetics of chronic rhinosinusitis: state of the field and directions forward. J Allergy Clin Immunol. 2013;131(4):5.

    Article  CAS  Google Scholar 

  13. Kern RC, Conley DB, Walsh W, et al. Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis. Am J Rhinol. 2008;22(6):549–59.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Burger J, Macek M, Stuhrmann M, et al. Genetic influences in the formation of nasal polyps. Lancet. 1991;337(8747):974.

    Article  CAS  PubMed  Google Scholar 

  15. Wang X, Moylan B, Leopold DA, et al. Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population. JAMA. 2000;284(14):1814–9.

    Article  CAS  PubMed  Google Scholar 

  16. Drake-Lee A. Nasal polyps in identical twins. J Laryngol Otol. 1992;106(12):1084–5.

    Article  CAS  PubMed  Google Scholar 

  17. Greisner WA, Settipane GA. Hereditary factor for nasal polyps. Allergy Asthma Proc. 1996;17(5):283–6.

    Article  PubMed  Google Scholar 

  18. Oakley GM, Curtin K, Orb Q, et al. Familial risk of chronic rhinosinusitis with and without nasal polyposis: genetics or environment. Int Forum Allergy Rhinol. 2015;5(4):276–82.

    Article  PubMed  Google Scholar 

  19. Orb Q, Curtin K, Oakley GM, et al. Familial risk of pediatric chronic rhinosinusitis. Laryngoscope. 2016;126(3):739–45.

    Article  PubMed  Google Scholar 

  20. Park CS, Cho JH, Park YJ. Toll-like receptor 2 gene polymorphisms in a Korean population: association with chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2011;144(1):96–100.

    Article  PubMed  Google Scholar 

  21. Tewfik MA, Bosse Y, Hudson TJ, et al. Assessment of Toll-like receptor 2 gene polymorphisms in severe chronic rhinosinusitis. J Otolaryngol Head Neck Surg. 2008;37(4):552–8.

    PubMed  Google Scholar 

  22. Tewfik MA, Bosse Y, Lemire M, et al. Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. Allergy. 2009;64(5):746–53.

    Article  CAS  PubMed  Google Scholar 

  23. Yazdani N, Amoli MM, Naraghi M, et al. Association between the functional polymorphism C-159T in the CD14 promoter gene and nasal polyposis: potential role in asthma. J Investig Allergol Clin Immunol. 2012;22(6):406–11.

    CAS  PubMed  Google Scholar 

  24. Adappa ND, Zhang Z, Palmer JN, et al. The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. Int Forum Allergy Rhinol. 2014;4(1):3–7.

    Article  PubMed  Google Scholar 

  25. Lee RJ, Xiong G, Kofonow JM, et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest. 2012;122(11):4145–59.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  26. Keles B, Cora T, Acar H, et al. Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis. Otolaryngol Head Neck Surg. 2008;139(4):580–5.

    Article  PubMed  Google Scholar 

  27. Ramirez-Anguiano J, Yamamoto-Furusho JK, Barquera R, et al. Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos. Otolaryngol Head Neck Surg. 2006;135(1):90–3.

    Article  PubMed  Google Scholar 

  28. Takeuchi K, Majima Y, Shimizu T, et al. Analysis of HLA antigens in Japanese patients with chronic sinusitis. Laryngoscope. 1999;109(2 Pt 1):275–8.

    Article  CAS  PubMed  Google Scholar 

  29. Luxenberger W, Posch U, Berghold A, et al. HLA patterns in patients with nasal polyposis. Eur Arch Otorhinolaryngol. 2000;257(3):137–9.

    Article  CAS  PubMed  Google Scholar 

  30. Molnar-Gabor E, Endreffy E, Rozsasi A. HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis. Laryngoscope. 2000;110(3 Pt 1):422–5.

    Article  CAS  PubMed  Google Scholar 

  31. Payne SC, Borish L, Steinke JW. Genetics and phenotyping in chronic sinusitis. J Allergy Clin Immunol. 2011;128(4):2.

    Article  Google Scholar 

  32. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 7th ed. Philadelphia, PA: Elsevier/Saunders; 2012.

    Google Scholar 

  33. Van Zele T, Claeys S, Gevaert P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy. 2006;61(11):1280–9.

    Article  CAS  PubMed  Google Scholar 

  34. Tomassen P, Van Zele T, Zhang N, et al. Pathophysiology of chronic rhinosinusitis. Proc Am Thorac Soc. 2011;8(1):115–20.

    Article  PubMed  CAS  Google Scholar 

  35. Van Crombruggen K, Zhang N, Gevaert P, et al. Pathogenesis of chronic rhinosinusitis: inflammation. J Allergy Clin Immunol. 2011;128(4):728–32.

    Article  CAS  PubMed  Google Scholar 

  36. Yea SS, Yang YI, Park SK, et al. Interleukin-4 C-590T polymorphism is associated with protection against nasal polyps in a Korean population. Am J Rhinol. 2006;20(5):550–3.

    Article  PubMed  Google Scholar 

  37. Buysschaert ID, Grulois V, Eloy P, et al. Genetic evidence for a role of IL33 in nasal polyposis. Allergy. 2010;65(5):616–22.

    Article  CAS  PubMed  Google Scholar 

  38. Schleimer RP. Immunopathogenesis of chronic rhinosinusitis and nasal polyposis. Annu Rev Pathol. 2017;12:331–57.

    Article  PubMed  CAS  Google Scholar 

  39. Soyka MB, Wawrzyniak P, Eiwegger T, et al. Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-gamma and IL-4. J Allergy Clin Immunol. 2012;130(5):1096.e10.

    Article  CAS  Google Scholar 

  40. Pothoven KL, Norton JE, Suh LA, et al. Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease. J Allergy Clin Immunol. 2017;139:1966.

    Article  CAS  PubMed  Google Scholar 

  41. London NR, Tharakan A, Rule AM, et al. Air pollutant-mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway. J Allergy Clin Immunol. 2016;138(6):1738.e4.

    Article  CAS  Google Scholar 

  42. Golovkine G, Faudry E, Bouillot S, et al. Pseudomonas aeruginosa transmigrates at epithelial cell-cell junctions, exploiting sites of cell division and senescent cell extrusion. PLoS Pathog. 2016;12(1):e1005377.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  43. Leino MS, Loxham M, Blume C, et al. Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors. PLoS One. 2013;8(8):e71278.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  44. Stevens WW, Lee RJ, Schleimer RP, et al. Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol. 2015;136(6):1442–53.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Hoggard M, Wagner Mackenzie B, Jain R, et al. Chronic rhinosinusitis and the evolving understanding of microbial ecology in chronic inflammatory mucosal disease. Clin Microbiol Rev. 2017;30(1):321–48.

    Article  CAS  PubMed  Google Scholar 

  46. Houtmeyers E, Gosselink R, Gayan-Ramirez G, et al. Regulation of mucociliary clearance in health and disease. Eur Respir J. 1999;13(5):1177–88.

    Article  CAS  PubMed  Google Scholar 

  47. Gudis D, Zhao KQ, Cohen NA. Acquired cilia dysfunction in chronic rhinosinusitis. Am J Rhinol Allergy. 2012;26(1):1–6.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Barshak MB, Durand ML. The role of infection and antibiotics in adult chronic rhinosinusitis. Laryngoscope Investig Otolaryngol. 2017;2:36.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Brook I. Microbiology of chronic rhinosinusitis. Eur J Clin Microbiol Infect Dis. 2016;35(7):1059–68.

    Article  CAS  PubMed  Google Scholar 

  50. Chow AW, Benninger MS, Brook I, et al. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis. 2012;54(8):e112.

    Article  CAS  Google Scholar 

  51. Kim ST, Choi JH, Jeon HG, et al. Comparison between polymerase chain reaction and fungal culture for the detection of fungi in patients with chronic sinusitis and normal controls. Acta Otolaryngol. 2005;125(1):72–5.

    Article  PubMed  Google Scholar 

  52. Murr AH, Goldberg AN, Vesper S. Fungal speciation using quantitative polymerase chain reaction (QPCR) in patients with and without chronic rhinosinusitis. Laryngoscope. 2006;116(8):1342–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Liu Q, Lu X, Bo M, et al. The microbiology of chronic rhinosinusitis with and without nasal polyps. Acta Otolaryngol. 2014;134(12):1251–8.

    Article  CAS  PubMed  Google Scholar 

  54. Blanken MO, Rovers MM, Molenaar JM, et al. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med. 2013;368(19):1791–9.

    Article  CAS  PubMed  Google Scholar 

  55. Stein RT, Sherrill D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354(9178):541–5.

    Article  CAS  PubMed  Google Scholar 

  56. Krishnamoorthy N, Khare A, Oriss TB, et al. Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma. Nat Med. 2012;18(10):1525–30.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  57. Kurai D, Saraya T, Ishii H, et al. Virus-induced exacerbations in asthma and COPD. Front Microbiol. 2013;4:293.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Wood AJ, Antoszewska H, Fraser J, et al. Is chronic rhinosinusitis caused by persistent respiratory virus infection? Int Forum Allergy Rhinol. 2011;1(2):95–100.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Liao B, Hu CY, Liu T, et al. Respiratory viral infection in the chronic persistent phase of chronic rhinosinusitis. Laryngoscope. 2014;124(4):832–7.

    Article  PubMed  Google Scholar 

  60. Cho GS, Moon BJ, Lee BJ, et al. High rates of detection of respiratory viruses in the nasal washes and mucosae of patients with chronic rhinosinusitis. J Clin Microbiol. 2013;51(3):979–84.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Ramakrishnan VR, Hauser LJ, Feazel LM, et al. Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical outcome. J Allergy Clin Immunol. 2015;136(2):42.e1.

    Article  Google Scholar 

  62. Abreu NA, Nagalingam NA, Song Y, et al. Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. Sci Transl Med. 2012;4(151):151ra124.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  63. Aurora R, Chatterjee D, Hentzleman J, et al. Contrasting the microbiomes from healthy volunteers and patients with chronic rhinosinusitis. JAMA Otolaryngol Head Neck Surg. 2013;139(12):1328–38.

    Article  PubMed  Google Scholar 

  64. Ramakrishnan VR, Frank DN. Impact of cigarette smoking on the middle meatus microbiome in health and chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015;5(11):981–9.

    Article  PubMed  Google Scholar 

  65. Hauser LJ, Ir D, Kingdom TT, et al. Investigation of bacterial repopulation after sinus surgery and perioperative antibiotics. Int Forum Allergy Rhinol. 2016;6(1):34–40.

    Article  PubMed  Google Scholar 

  66. Suh JD, Cohen NA, Palmer JN. Biofilms in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2010;18(1):27–31.

    Article  PubMed  Google Scholar 

  67. Wood AJ, Fraser J, Swift S, et al. Are biofilms associated with an inflammatory response in chronic rhinosinusitis? Int Forum Allergy Rhinol. 2011;1(5):335–9.

    Article  PubMed  Google Scholar 

  68. Pant H, Beroukas D, Kette FE, et al. Nasal polyp cell populations and fungal-specific peripheral blood lymphocyte proliferation in allergic fungal sinusitis. Am J Rhinol Allergy. 2009;23(5):453–60.

    PubMed  Google Scholar 

  69. Pant H, Hughes A, Miljkovic D, et al. Accumulation of effector memory CD8+ T cells in nasal polyps. Am J Rhinol Allergy. 2013;27(5):117.

    Article  Google Scholar 

  70. Bachert C, Zhang N, van Zele T, et al. Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis. Clin Allergy Immunol. 2007;20:163–75.

    CAS  PubMed  Google Scholar 

  71. Conley DB, Tripathi A, Seiberling KA, et al. Superantigens and chronic rhinosinusitis II: analysis of T-cell receptor V beta domains in nasal polyps. Am J Rhinol. 2006;20(4):451–5.

    Article  PubMed  Google Scholar 

  72. Conley DB, Tripathi A, Seiberling KA, et al. Superantigens and chronic rhinosinusitis: skewing of T-cell receptor V beta-distributions in polyp-derived CD4+ and CD8+ T cells. Am J Rhinol. 2006;20(5):534–9.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Pynnonen MA, Mukerji SS, Kim HM, et al. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Arch Otolaryngol Head Neck Surg. 2007;133(11):1115–20.

    Article  PubMed  Google Scholar 

  74. Harvey R, Hannan SA, Badia L, et al. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;3:CD006394.

    Google Scholar 

  75. Chong LY, Head K, Hopkins C, et al. Saline irrigation for chronic rhinosinusitis. Cochrane Database Syst Rev. 2016;4:CD011995.

    PubMed  Google Scholar 

  76. Bachmann G, Hommel G, Michel O. Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. Eur Arch Otorhinolaryngol. 2000;257(10):537–41.

    Article  CAS  PubMed  Google Scholar 

  77. Hauptman G, Ryan MW. The effect of saline solutions on nasal patency and mucociliary clearance in rhinosinusitis patients. Otolaryngol Head Neck Surg. 2007;137(5):815–21.

    Article  PubMed  Google Scholar 

  78. Pinto JM, Elwany S, Baroody FM, et al. Effects of saline sprays on symptoms after endoscopic sinus surgery. Am J Rhinol. 2006;20(2):191–6.

    Article  PubMed  Google Scholar 

  79. Snidvongs K, Kalish L, Sacks R, et al. Topical steroid for chronic rhinosinusitis without polyps. Cochrane Database Syst Rev. 2011;(8):CD009274.

    Google Scholar 

  80. Kalish L, Snidvongs K, Sivasubramaniam R, et al. Topical steroids for nasal polyps. Cochrane Database Syst Rev. 2012;12:CD006549.

    PubMed  Google Scholar 

  81. Head K, Chong LY, Piromchai P, et al. Systemic and topical antibiotics for chronic rhinosinusitis. Cochrane Database Syst Rev. 2016;4:CD011994.

    PubMed  Google Scholar 

  82. Dubin MG, Liu C, Lin SY, et al. American Rhinologic Society member survey on “maximal medical therapy” for chronic rhinosinusitis. Am J Rhinol. 2007;21(4):483–8.

    Article  PubMed  Google Scholar 

  83. Dubin MG, Kuhn FA, Melroy CT. Radiographic resolution of chronic rhinosinusitis without polyposis after 6 weeks vs 3 weeks of oral antibiotics. Ann Allergy Asthma Immunol. 2007;98(1):32–5.

    Article  PubMed  Google Scholar 

  84. Van Zele T, Gevaert P, Holtappels G, et al. Oral steroids and doxycycline: two different approaches to treat nasal polyps. J Allergy Clin Immunol. 2010;125(5):1076.e4.

    Google Scholar 

  85. Henehan M, Montuno M, De Benedetto A. Doxycycline as an anti-inflammatory agent: updates in dermatology. J Eur Acad Dermatol Venereol. 2017;31:1800.

    Article  CAS  PubMed  Google Scholar 

  86. Pinto Bezerra Soter AC, Bezerra TF, Pezato R, et al. Prospective open-label evaluation of long-term low-dose doxycycline for difficult-to-treat chronic rhinosinusitis with nasal polyps. Rhinology. 2017;55:175.

    Article  CAS  PubMed  Google Scholar 

  87. Zeng M, Li ZY, Ma J, et al. Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study. BMC Immunol. 2015;16:37.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  88. Luo Q, Chen F, Liu W, et al. Evaluation of long-term clarithromycin treatment in adult Chinese Patients with chronic rhinosinusitis without nasal polyps. ORL J Otorhinolaryngol Relat Spec. 2011;73(4):206–11.

    Article  CAS  PubMed  Google Scholar 

  89. Yamada T, Fujieda S, Mori S, et al. Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage. Am J Rhinol. 2000;14(3):143–8.

    Article  CAS  PubMed  Google Scholar 

  90. Ichimura K, Shimazaki Y, Ishibashi T, et al. Effect of new macrolide roxithromycin upon nasal polyps associated with chronic sinusitis. Auris Nasus Larynx. 1996;23:48–56.

    Article  CAS  PubMed  Google Scholar 

  91. Lasso A, Masoudian P, Quinn JG, et al. Long-term low-dose macrolides for chronic rhinosinusitis in adults - a systematic review of the literature. Clin Otolaryngol. 2017;42:637.

    Article  CAS  PubMed  Google Scholar 

  92. Brook I, Foote PA, Frazier EH. Microbiology of acute exacerbation of chronic sinusitis. Ann Otol Rhinol Laryngol. 2005;114(7):573–6.

    Article  PubMed  Google Scholar 

  93. Sabino HA, Valera FC, Aragon DC, et al. Amoxicillin-clavulanate for patients with acute exacerbation of chronic rhinosinusitis: a prospective, double-blinded, placebo-controlled trial. Int Forum Allergy Rhinol. 2017;7:135.

    Article  PubMed  Google Scholar 

  94. Garbutt JM, Banister C, Spitznagel E, et al. Amoxicillin for acute rhinosinusitis: a randomized controlled trial. JAMA. 2012;307(7):685–92.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  95. Taylor MJ, Ponikau JU, Sherris DA, et al. Detection of fungal organisms in eosinophilic mucin using a fluorescein-labeled chitin-specific binding protein. Otolaryngol Head Neck Surg. 2002;127(5):377–83.

    Article  PubMed  Google Scholar 

  96. Shin SH, Ponikau JU, Sherris DA, et al. Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol. 2004;114(6):1369–75.

    Article  CAS  PubMed  Google Scholar 

  97. Ponikau JU, Sherris DA, Weaver A, et al. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol. 2005;115(1):125–31.

    Article  CAS  PubMed  Google Scholar 

  98. Fokkens WJ, van Drunen C, Georgalas C, et al. Role of fungi in pathogenesis of chronic rhinosinusitis: the hypothesis rejected. Curr Opin Otolaryngol Head Neck Surg. 2012;20(1):19–23.

    Article  PubMed  Google Scholar 

  99. Sacks PL, Harvey RJ, Rimmer J, et al. Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis. Cochrane Database Syst Rev. 2011;(8):CD008263.

    Google Scholar 

  100. Smith TL, Kern R, Palmer JN, et al. Medical therapy vs surgery for chronic rhinosinusitis: a prospective, multi-institutional study with 1-year follow-up. Int Forum Allergy Rhinol. 2013;3(1):4–9.

    Article  PubMed  Google Scholar 

  101. Brook I. Sinusitis of odontogenic origin. Otolaryngol Head Neck Surg. 2006;135(3):349–55.

    Article  PubMed  Google Scholar 

  102. Zirk M, Dreiseidler T, Pohl M, et al. Odontogenic sinusitis maxillaris: a retrospective study of 121 cases with surgical intervention. J Craniomaxillofac Surg. 2017;45(4):520–5.

    Article  PubMed  Google Scholar 

  103. Laury AM, Wise SK. Chapter 7: Allergic fungal rhinosinusitis. Am J Rhinol Allergy. 2013;27(Suppl 1):26.

    Article  PubMed  Google Scholar 

  104. Bent JP, Kuhn FA. Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg. 1994;111(5):580–8.

    Article  PubMed  Google Scholar 

  105. Gan EC, Thamboo A, Rudmik L, et al. Medical management of allergic fungal rhinosinusitis following endoscopic sinus surgery: an evidence-based review and recommendations. Int Forum Allergy Rhinol. 2014;4(9):702–15.

    Article  PubMed  Google Scholar 

  106. Sykes DA, Wilson R, Chan KL, et al. Relative importance of antibiotic and improved clearance in topical treatment of chronic mucopurulent rhinosinusitis. A controlled study. Lancet. 1986;2(8503):359–60.

    Article  CAS  PubMed  Google Scholar 

  107. Jervis-Bardy J, Boase S, Psaltis A, et al. A randomized trial of mupirocin sinonasal rinses versus saline in surgically recalcitrant staphylococcal chronic rhinosinusitis. Laryngoscope. 2012;122(10):2148–53.

    Article  CAS  PubMed  Google Scholar 

  108. Desrosiers MY, Salas-Prato M. Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: results of a controlled trial. Otolaryngol Head Neck Surg. 2001;125(3):265–9.

    Article  CAS  PubMed  Google Scholar 

  109. Videler WJ, van Drunen CM, Reitsma JB, et al. Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study. Rhinology. 2008;46(2):92–8.

    CAS  PubMed  Google Scholar 

  110. Weschta M, Rimek D, Formanek M, et al. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol. 2004;113(6):1122–8.

    Article  CAS  PubMed  Google Scholar 

  111. Ebbens FA, Georgalas C, Luiten S, et al. The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. Laryngoscope. 2009;119(2):401–8.

    Article  CAS  PubMed  Google Scholar 

  112. Gerlinger I, Fittler A, Fonai F, et al. Postoperative application of amphotericin B nasal spray in chronic rhinosinusitis with nasal polyposis, with a review of the antifungal therapy. Eur Arch Otorhinolaryngol. 2009;266(6):847–55.

    Article  CAS  PubMed  Google Scholar 

  113. Hashemian F, Hashemian F, Molaali N, et al. Clinical effects of topical antifungal therapy in chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial of intranasal fluconazole. EXCLI J. 2016;15:95–102.

    PubMed  PubMed Central  Google Scholar 

  114. Wallwork B, Coman W, Mackay-Sim A, et al. A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope. 2006;116(2):189–93.

    Article  CAS  PubMed  Google Scholar 

  115. Videler WJ, Badia L, Harvey RJ, et al. Lack of efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial. Allergy. 2011;66(11):1457–68.

    Article  CAS  PubMed  Google Scholar 

  116. Zeng M, Long XB, Cui YH, et al. Comparison of efficacy of mometasone furoate versus clarithromycin in the treatment of chronic rhinosinusitis without nasal polyps in Chinese adults. Am J Rhinol Allergy. 2011;25(6):203.

    Article  Google Scholar 

  117. Varvyanskaya A, Lopatin A. Efficacy of long-term low-dose macrolide therapy in preventing early recurrence of nasal polyps after endoscopic sinus surgery. Int Forum Allergy Rhinol. 2014;4(7):533–41.

    Article  PubMed  Google Scholar 

  118. Haxel BR, Clemens M, Karaiskaki N, et al. Controlled trial for long-term low-dose erythromycin after sinus surgery for chronic rhinosinusitis. Laryngoscope. 2015;125(5):1048–55.

    Article  CAS  PubMed  Google Scholar 

  119. Kennedy DW, Kuhn FA, Hamilos DL, et al. Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope. 2005;115(10):1793–9.

    Article  CAS  PubMed  Google Scholar 

  120. Fowler K, Duncavage J, Murray J, et al. Chronic sinusitis and intravenous antibiotic therapy: resolution, recurrence, and adverse events. J Allergy Clin Immunol. 2003;111:S85.

    Article  Google Scholar 

  121. Ponikau JU, Sherris DA, Kephart GM, et al. Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma? J Allergy Clin Immunol. 2003;112(5):877–82.

    Article  PubMed  Google Scholar 

  122. Joki S, Toskala E, Saano V, Nuutinen J. Correlation between ciliary beat frequency and the structure of ciliated epithelia in pathologic human nasal mucosa. Laryngoscope. 1998;108(3):426–30.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Otolaryngology, Harvard Medical School, Boston, MA, USA

    Ahmad R. Sedaghat

  2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Ahmad R. Sedaghat

  3. Division of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Ahmad R. Sedaghat

  4. Department of Otolaryngology and Communications Enhancement, Boston Children’s Hospital, Boston, MA, USA

    Ahmad R. Sedaghat

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  1. Ahmad R. Sedaghat
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Correspondence to Ahmad R. Sedaghat .

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Editors and Affiliations

  1. Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Marlene L. Durand

  2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA

    Daniel G. Deschler

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Sedaghat, A.R. (2018). Chronic Rhinosinusitis. In: Durand, M., Deschler, D. (eds) Infections of the Ears, Nose, Throat, and Sinuses. Springer, Cham. https://doi.org/10.1007/978-3-319-74835-1_13

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  • DOI: https://doi.org/10.1007/978-3-319-74835-1_13

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