Abstract
Advanced heart failure is a prevalent and complex disease with high morbidity and mortality. While there are many causes for heart failure, some of the common ones include ischemia, hypertension, alcohol, and viral infections. Management of this disease involves a multidisciplinary team approach and a myriad of resources. Treatment goals include afterload and preload reduction, improving organ and tissue perfusion, and ameliorating signs and symptoms of heart failure such as dyspnea, fatigue, and edema. Treatment options include, but are not limited to, a multitude of medications including intravenous diuretics and inotropic agents for symptomatic control. Quality of life for patients afflicted with this disease process is poor, requiring frequent hospitalizations. Palliative care is an integral part of the treatment approach and helps alleviate some of the suffering.
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References
Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646–59. https://doi.org/10.1161/CIRCRESHAHA.113.300268.
Massie BM, Shah NB. Evolving trends in the epidemiologic factors of heart failure: rationale for preventive strategies and comprehensive disease management. Am Heart J. 1997;133:703–12.
Norton C, Georgiopoulou VV, Kalogeropoulos AP, et al. Epidemiology and cost of advanced heart failure. Prog Cardiovas Dis. 2011;54(2):78–85.
Friedrich EB, Bohm M. Management of end stage heart failure. Heart. 2007;93(5):626–31. https://doi.org/10.1136/hrt.2006.098814.
Abouezzeddine OF, Redfield MM. Who has advanced heart failure? Definition and epidemiology. Congest Heart Fail. 2011;17(4):160–8. https://doi.org/10.1111/j.1751-7133.2011.00246.x.
Chaudhry SP, Stewart GC. Advanced heart failure: prevalence, natural history, and prognosis. Heart Fail Clin. 2016;12(3):323–30.
Ali A, Aronow WS, Fleg JL. Higher New York Heart Association classes and increased mortality and hospitalization in heart failure patients with preserved left ventricular function. Am Heart J. 2006;151(2):444–50.
Remme WJ. Overview of the relationship between ischemia and congestive heart failure. Clin Cardiol. 2000;23:IV-4–8. https://doi.org/10.1002/clc.4960230703.
Bui AL, Horwich TB, Fonarow GC. Epidemiology and risk profile of heart failure. Nat Rev Cardiol. 2011;8(1):30–41.
Sogol J, Javaheri S, Javaheri A. Sleep Apnea, heart failure, and pulmonary hypertension. Curr Heart Fail Rep. 2013;10(4):315–20.
Leiro MGC, Martin MJP. Management of advanced or refractory heart failure. Rev Esp Cardiol. 2004;57:869–83. Vol. 57, num.09. https://doi.org/10.1016/S1885-5857(06)60652-X.
Rame JE, Dries DL, Drazner MH. The prognostic value of the physical examination in patients with chronic heart failure. CHF. 2003;9(3):170–5.
Drazner MH, Rame JE, Stevenson LW, et al. Prognostic importance of elevated jugular venous pressure and a third heart sounds in patients with heart failure. N Engl J Med. 2001;345(8):574–81. https://doi.org/10.1056/NEJMoa010641.
Nohria A, Lewis E, Stevenson LW. Medical management of advanced heart failure. JAMA. 2002;287(5):628–40. https://doi.org/10.1001/jama.287.5.628.
Stevenson LW. Hemodynamic goals are relevant. Circulation. 2006;113:1020–33.
Potluri S, Ventura HO, Mulumudi M. Cardiac troponin levels in heart failure. Cardiol Rev. 2004;12(1):21–5.
Shah BN, Greaves K. The cardiorenal syndrome. A review. Int J Nephrol. 2011;2011:920195. https://doi.org/10.4061/2011/920195.
Pokhrel N, Maharjan N, Dhakal B, et al. Cardiorenal syndrome: A literature review. Exp Clin Cardiol. 2008;13(4):165–70.
Makani H, Bangalone S, Romero J, et al. Peripheral edema associated with calcium channel blockers: incidence and withdrawal rate- a meta- analysis of randomized trials. J Hypertens. 2011;29(7):1270–80. https://doi.org/10.1097/HJH.0b013e3283472643.
Packer M, Carson P, Elkayam U, et al. Effect of amlodipine on the survival of patients with severe chronic heart failure due to nonischemic cardiomyopathy. JACC Heart Fail. 2013;1(4):308–14.
Colucci WS, Fifer MA, Lorell BH, et al. Calcium channel blockers in congestive heart failure: theoretic considerations and clinical experience. Am J Med. 1985;78(2B):9–17.
Gibbs CR, Jackson G, GYH L. Non-drug management. BMJ. 2000;320(7231):366–9.
Yusuf S, Pitt B, Davis CE, et al. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991;325(5):293–302.
The Consensus Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. N Engl J Med. 1987;316:1429–35.
Young JB, Dunlap ME, Pfeffer MA, et al. Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials. Circulation. 2004;110(17):2618–26.
Lakhdar R, Al-Mallah MH, Lanfear DE. Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combination of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in patients with left ventricular dysfunction: a systematic review and meta-analysis of randomized controlled trials. J Card Fail. 2008;14(3):181–8.
Mcmurray JJV, Packer M, Desai AS, et al. Angiotensin-Neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371:993–1004. https://doi.org/10.1056/NEJMoa1409077.
Goldstein S, Hjalmarson A. The mortality effect of metoprolol CR/XL in patients with heart failure: results of the MERIT-HF trial. Clin Cardiol. 1999;22(Suppl 5):V30–5.
CIBIS-II Investigators. The Cardiac Insufficiency Bisoprolol Study (CIBIS-II): a randomized trial. Lancet. 1999;353(9146):9–13.
Packer M, Bristow MR, Cohn JN, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med. 1996;334:1349–55.
Packer M, Coats AJS, Fowler MB, et al. Effect of Carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001;344:1651–8.
Barrese V, Taglialatela M. New advances in beta-blocker therapy in heart failure. Front Physiol. 2013;4:323. https://doi.org/10.3389/fphys.2013.00323.
Gheorghiade M, Colucci WS, Swedberg K. B-Blockers in chronic heart failure. Circulation. 2003;107:1570–5.
Taylor AL, Ziesche S, Yancy C, et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004;351:2049–57. https://doi.org/10.1056/NEJMoa042934.
Cole RT, Kalogeropoulos AP, Georgiopoulou VV, et al. Hydralazine and isosorbide dinitrate in heart failure: historical perspective, mechanisms, and future directions. Circulation. 2011;123(21):2414–22.
Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341:709–17.
Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309–21.
Oh SW, Han SY. Loop diuretics in clinical practice. Electrolyte Blood Press. 2015;13(1):17–21. https://doi.org/10.5049/EBP.2015.13.1.17.
De Bruyne LKM. Mechanisms and management of diuretic resistance in congestive heart failure. Postgrad Med J. 2003;79(931):268–71. https://doi.org/10.1146/pmj.79.931.268.
Felker GM, Lee KL, Bull DA, et al. Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med. 2011;364:797–805. https://doi.org/10.1056/NEJMoa1005419.
Costanzo MR, Guglin ME, Saltzberg MT, et al. Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol. 2007;49(6):675–83.
Bart BA, Goldsmith ST, Lee KL, et al. Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N Engl J Med. 2012;367:2296–301. https://doi.org/10.1056/NEJMoa1210357.
Konstam MA, Gheorghiade M, Burnett JC, et al. Effects of oral tolvaptan in patients hospitalized for worsening heart failure. JAMA. 2007;297(12):1319–31.
O’Connor CM, Starling RC, Hernandez AF, et al. Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med. 2011;365(8):773.
Strickberger SA, Conti J, Daoud EG, et al. Patient selection for cardiac resynchronization therapy. Circulation. 2005;111:2146–50.
Stevenson LW. Clinical use of inotropic therapy for heart failure: looking backward or forward?: Part II: chronic inotropic therapy. Circulation. 2003;108:492–7.
Tariq S, Aronow WS. Use of inotropic agents in treatment of systolic heart failure. Int J Mol Sci. 2015;16(12):29060–8. https://doi.org/10.3390/ijms161226147.
Gorodeski EZ, Chu EC, Reese JR, et al. Prognosis of chronic dobutamine or mirinone infusions for stage D heart failure. Circ Heart Fail. 2009;2:320–4.
LeMond L, Allen LA. Palliative care and hospice in advanced heart failure. Prog Cardiovasc Dis. 2011;54(2):168–78. https://doi.org/10.1016/j.pcad.2011.03.012.
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Murtaza, G., Cotts, W.G. (2018). Management of Advanced Heart Failure: An Overview. In: Desai, C., Cotts, W., Lerma, E., Rudnick, M. (eds) Ventricular-Assist Devices and Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-74657-9_1
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