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Vitamin D and Autoimmune Diseases

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Extraskeletal Effects of Vitamin D

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Vitamin D has a crucial role in preserving musculoskeletal health and modulating the immune system; the latter has been a subject of great interest in recent years. Vitamin D deficiency is common in the general population and even more so among patients with various autoimmune diseases. Vitamin D deficiency has been previously linked to various autoimmune diseases, including multiple sclerosis, type 1 diabetes, inflammatory bowel diseases, and rheumatoid arthritis. In this chapter, the association between vitamin D deficiency and various autoimmune diseases will be discussed, as well as the possible therapeutic implications derived from this relationship.

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Abbreviations

AIH:

Autoimmune hepatitis

AITD:

Autoimmune thyroid diseases

BMI:

Body mass index

CD:

Crohn’s disease

dcSSc:

Diffuse cutaneous systemic sclerosis

IBD:

Inflammatory bowel diseases

JoSLE:

Juvenile-onset systemic lupus erythematosus

KO:

Knockout

lcSSc:

Limited cutaneous systemic sclerosis

MRI:

Magnetic resonance imaging

MS:

Multiple sclerosis

PBC:

Primary biliary cholangitis

RA:

Rheumatoid arthritis

RR:

Relative risk

SLE:

Systemic lupus erythematosus

SS:

Systemic sclerosis

TGF:

Transforming growth factor

Th:

T helper cells

Treg:

T regulatory cells

UC:

Ulcerative colitis

UV:

Ultraviolet

UVB:

Ultraviolet B

VDR:

Vitamin D receptor

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Authors and Affiliations

  1. Sheba Medical Center, The Zabludowicz Center for Autoimmune Diseases, Ramat-Gan, Israel

    Shir Azrielant MD & Yehuda Shoenfeld MD, FRCP, MaACR

  2. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Shir Azrielant MD & Yehuda Shoenfeld MD, FRCP, MaACR

  3. Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel

    Yehuda Shoenfeld MD, FRCP, MaACR

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  1. Shir Azrielant MD
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  2. Yehuda Shoenfeld MD, FRCP, MaACR
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Correspondence to Yehuda Shoenfeld MD, FRCP, MaACR .

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  1. Lenox Hill Hospital, New York, New York, USA

    Emilia Pauline Liao

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Azrielant, S., Shoenfeld, Y. (2018). Vitamin D and Autoimmune Diseases. In: Liao, E. (eds) Extraskeletal Effects of Vitamin D. Contemporary Endocrinology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-73742-3_2

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  • DOI: https://doi.org/10.1007/978-3-319-73742-3_2

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