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Immune Functions of Platelets

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Antibody Therapy

Abstract

Platelets are megakaryocyte-derived cellular fragments lacking a nucleus and are classically known for their crucial role in supporting hemostasis. Besides their hemostatic function, it is becoming increasingly clear that platelets are much more diverse and that they are capable of a wide range of immune-sensing functions. This chapter will focus on these non-hemostatic immunological aspects, especially in an inflammatory setting. The cross talk between platelets and pathogens as well as between platelets and various target cells will be discussed, in order to highlight the emerging and important immune features of platelets.

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Authors and Affiliations

  1. Division of Hematology and Transfusion Medicine, Lund University, BMC C14, Klinikgatan 26, Lund, 221 84, Sweden

    Rick Kapur & John W. Semple

  2. Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, ON, Canada

    John W. Semple

  3. The Toronto Platelet Immunobiology Group, St. Michael’s Hospital, Toronto, ON, Canada

    John W. Semple

  4. Canadian Blood Services, Toronto, ON, Canada

    John W. Semple

  5. Departments of Pharmacology, Medicine, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    John W. Semple

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  1. Department of Pediatrics, Medical Faculty of the University of Basel, Basel, Switzerland

    Paul Imbach

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Kapur, R., Semple, J.W. (2018). Immune Functions of Platelets. In: Imbach, P. (eds) Antibody Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-68038-5_17

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