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Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA pp 465–487Cite as

Utilization of Molecular Markers in the Diagnosis and Management of Thyroid Nodules

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Abstract

Maximizing the information obtained through ultrasound examination and fine needle aspiration biopsy of the patient with an indeterminate thyroid nodule by obtaining a molecular profile is increasingly being utilized to guide clinical management. Several molecular tests have recently become available in the last few years. These molecular tests evaluate nodules for the presence of mutations/rearrangements or for the expression of differentially expressed mRNAs or miRNAs. Differences in test characteristics and performance exist for each assay and are discussed here to aid in test selection and clinical interpretation of the results.

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Authors and Affiliations

  1. Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA

    Susan J. Hsiao MD, PhD

  2. Department of Pathology, Division of Molecular & Genomic Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Yuri E. Nikiforov MD, PhD

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  1. Susan J. Hsiao MD, PhD
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  2. Yuri E. Nikiforov MD, PhD
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Correspondence to Yuri E. Nikiforov MD, PhD .

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Editors and Affiliations

  1. University of Arizona, College of Medicine, Phoenix, AZ, USA

    Daniel S. Duick

  2. Geisel School of Medicine at Dartmouth, Thyroid Center of New Hampshire, St. Joseph Hospital, Nashua, NH, USA

    Robert A. Levine

  3. Florida State University, College of Medicine, Tallahassee, FL, USA

    Mark A. Lupo

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Hsiao, S.J., Nikiforov, Y.E. (2018). Utilization of Molecular Markers in the Diagnosis and Management of Thyroid Nodules. In: Duick, D., Levine, R., Lupo, M. (eds) Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA . Springer, Cham. https://doi.org/10.1007/978-3-319-67238-0_15

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