Skip to main content

Nail Unit Lichen Planus

  • Chapter
  • 2093 Accesses

Abstract

Nail abnormalities are seen in approximately 10% of adult patients with cutaneous lichen planus, but in most of the cases nail LP is not associated with skin or mucosal lesions, a mild oral LP being detected in less then one-fourth of the patients only after examination. Most commonly, nail LP involves the nail matrix and presents with nail thinning with longitudinal ridging and fissuring (onychorrhexis) that usually involve several-all nails. Dorsal pterygium is a possible outcome and indicates focal scarring of the nail matrix. Unless the patient has clinical signs of LP of the skin of mucosae, diagnosis of nail LP requires a biopsy, as the differential diagnosis is not always easy clinically. Moreover, as treatment of nail LP requires systemic or intralesional drugs, in order to avoid permanent scarring, having a pathological confirmation of the diagnosis helps to increase patient’s acceptance of therapy. Treatment of nail LP is difficult, as not all patients respond to therapy. Optimal therapy is still lacking, and systemic or intralesional steroids (the choice is based on the numbers of nails involved) are the treatment of choice.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   74.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   84.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Alsenaid AA, Eder I, Ruzicka T, Braun-Falco M, Wolf R. Successful treatment of nail lichen planus with alitretinoin: report of 2 cases and review of the literature. Dermatology. 2014;229:293–6.

    Article  Google Scholar 

  2. Baran LR. Yellow nail syndrome and nail lichen planus may be induced by a common culprit. Focus on dental restorative substances. Front Med (Lausanne). 2014;2:46.

    Google Scholar 

  3. Baran R, Perrin C. Nail degloving, a polyetiologic condition with 3 main patterns: a new syndrome. J Am Acad Dermatol. 2008;58:232–7.

    Article  Google Scholar 

  4. Baran R, Jancovici E, Sayag J, Dawber RP. Longitudinal melanonychia in lichen planus. Br J Dermatol. 1985;113:369–70.

    Article  CAS  Google Scholar 

  5. Cinotti E, Fouilloux B, Perrot JL, Labeille B, Douchet C, Cambazard F. Confocal microscopy for healthy and pathological nail. J Eur Acad Dermatol Venereol. 2014;28:853–8.

    Article  CAS  Google Scholar 

  6. Goettmann S, Zaraa I, Moulonguet I. Nail lichen planus: epidemiological, clinical, pathological, therapeutic and prognosis study of 67 cases. J Eur Acad Dermatol Venereol. 2012;26:1304–9.

    Article  CAS  Google Scholar 

  7. Iorizzo M. Nail lichen planus – a possible new indication for oral alitretinoin. J Eur Acad Dermatol Venereol. 2016;30(3):509–10.

    Article  Google Scholar 

  8. Juhlin L, Baran R. Longitudinal melanonychia after healing of lichen planus. Acta Derm Venereol. 1989;69:338–9.

    CAS  PubMed  Google Scholar 

  9. Kato Y, Hayakawa R, Shiraki R, Ozeki K. A case of lichen planus caused by mercury allergy. Br J Dermatol. 2003;148:1268–9.

    Article  CAS  Google Scholar 

  10. Khullar G, Handa S, De D, Saikia UN. Bullous lichen planus of the nails. JAMA Dermatol. 2015;151:674–5.

    Article  Google Scholar 

  11. Nakamura R, Broce AA, Palencia DP, Ortiz NI, Leverone A. Dermatoscopy of nail lichen planus. Int J Dermatol. 2013;52:684–7.

    Article  Google Scholar 

  12. Nishizawa A, Satoh T, Yokozeki H. Close association between metal allergy and nail lichen planus: detection of causative metals in nail lesions. J Eur Acad Dermatol Venereol. 2013;27(2):e231–4.

    Article  CAS  Google Scholar 

  13. Pandhi D, Singal A, Bhattacharya SN. Lichen planus in childhood: a series of 316 patients. Pediatr Dermatol. 2014;31:59–67.

    Article  Google Scholar 

  14. Pinter A, Pätzold S, Kaufmann R. Lichen planus of nails – successful treatment with Alitretinoin. J Dtsch Dermatol Ges. 2011;9:1033–4.

    Google Scholar 

  15. Piraccini BM, Saccani E, Starace M, Balestri R, Tosti A. Nail lichen planus: response to treatment and long term follow-up. Eur J Dermatol. 2010;20:489–96.

    Google Scholar 

  16. Piraccini BM, Bruni F, Starace M. Dermoscopy of non-skin cancer nail disorders. Dermatol Ther. 2012;25:594–602.

    Article  Google Scholar 

  17. Renker T, Haneke E, Röcken C, Borradori L. Systemic light-chain amyloidosis revealed by progressive nail involvement, diffuse alopecia and sicca syndrome: report of an unusual case with a review of the literature. Dermatol. 2014;228:97–102.

    Article  CAS  Google Scholar 

  18. Richert B, André J. Trachyonychia: a clinical and histological study of 22 cases. J Eur Acad Dermatol Venereol. 1999;12:126.

    Article  Google Scholar 

  19. Sanli H, Arat M, Oskay T, Gürman G. Evaluation of nail involvement in patients with chronic cutaneous graft versus host disease: a single-center study from Turkey. Int J Dermatol. 2004;43:176–80.

    Article  Google Scholar 

  20. Scalf LA, Fowler JF Jr, Morgan KW, Looney SW. Dental metal allergy in patients with oral, cutaneous, and genital lichenoid reactions. Am J Contact Dermat. 2001;12(3):146–50.

    CAS  PubMed  Google Scholar 

  21. Scher RK, Fischbein R, Ackerman AB. Twenty-nail dystrophy: A variant of lichen planus. Arch Dermatol. 1978;114:612–3.

    Article  CAS  Google Scholar 

  22. Shiohara T, Kano Y. Lichen planus. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. London: Mosby Elsevier; 2008. p. 511.

    Google Scholar 

  23. Suarez SM, Scher RK. Idiopathic atrophy of the nails: a possible hereditary association. Pediatr Dermatol. 1990;7:39–41.

    Article  CAS  Google Scholar 

  24. Tosti A, Peluso AM, Fanti PA, Piraccini BM. Nail lichen planus: clinical and pathologic study of twenty-four patients. J Am Acad Dermatol. 1993;28:724–30.

    Article  CAS  Google Scholar 

  25. Tosti A, Bardazzi F, Piraccini BM, et al. Idiopathic trachyonychia (twenty-nail dystrophy): a pathological study of 23 patients. Br J Dermatol. 1994;131:866–72.

    Article  CAS  Google Scholar 

  26. Tosti A, Piraccini BM, Fanti PA, Bardazzi F, Di Landro A. Idiopathic atrophy of the nails: clinical and pathological study of 2 cases. Dermatology. 1995;190:116–8.

    Article  CAS  Google Scholar 

  27. Tosti A, Ghetti E, Piraccini BM, Fanti PA. Lichen planus of the nails and fingertips. Eur J Dermatol. 1998;8:447–8.

    CAS  PubMed  Google Scholar 

  28. Tosti A, Piraccini BM, Cameli N. Nail changes in lichen planus may resemble those of yellow nail syndrome. Br J Dermatol. 2000;142:848–9.

    Article  CAS  Google Scholar 

  29. Tosti A, Piraccini BM, Cambiaghi S, Jorizzo M. Nail lichen planus in children: clinical features, response to treatment, and long-term follow-up. Arch Dermatol. 2001;137:1027–32.

    CAS  Google Scholar 

  30. Yokozeki H, Niiyama S, Nishioka K. Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with gold allergy. Br J Dermatol. 2005;152(5):1087–9.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bianca Maria Piraccini .

Editor information

Editors and Affiliations

7.1 Supplementary Electronic Material

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Cite this chapter

Piraccini, B.M., Starace, M., Misciali, C., Fanti, P.A. (2018). Nail Unit Lichen Planus. In: Rubin, A.I., Jellinek, N.J., Daniel, C.R., Scher, R.K. (eds) Scher and Daniel’s Nails. Springer, Cham. https://doi.org/10.1007/978-3-319-65649-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-65649-6_7

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-65647-2

  • Online ISBN: 978-3-319-65649-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics