Abstract
Nail abnormalities are seen in approximately 10% of adult patients with cutaneous lichen planus, but in most of the cases nail LP is not associated with skin or mucosal lesions, a mild oral LP being detected in less then one-fourth of the patients only after examination. Most commonly, nail LP involves the nail matrix and presents with nail thinning with longitudinal ridging and fissuring (onychorrhexis) that usually involve several-all nails. Dorsal pterygium is a possible outcome and indicates focal scarring of the nail matrix. Unless the patient has clinical signs of LP of the skin of mucosae, diagnosis of nail LP requires a biopsy, as the differential diagnosis is not always easy clinically. Moreover, as treatment of nail LP requires systemic or intralesional drugs, in order to avoid permanent scarring, having a pathological confirmation of the diagnosis helps to increase patient’s acceptance of therapy. Treatment of nail LP is difficult, as not all patients respond to therapy. Optimal therapy is still lacking, and systemic or intralesional steroids (the choice is based on the numbers of nails involved) are the treatment of choice.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Alsenaid AA, Eder I, Ruzicka T, Braun-Falco M, Wolf R. Successful treatment of nail lichen planus with alitretinoin: report of 2 cases and review of the literature. Dermatology. 2014;229:293–6.
Baran LR. Yellow nail syndrome and nail lichen planus may be induced by a common culprit. Focus on dental restorative substances. Front Med (Lausanne). 2014;2:46.
Baran R, Perrin C. Nail degloving, a polyetiologic condition with 3 main patterns: a new syndrome. J Am Acad Dermatol. 2008;58:232–7.
Baran R, Jancovici E, Sayag J, Dawber RP. Longitudinal melanonychia in lichen planus. Br J Dermatol. 1985;113:369–70.
Cinotti E, Fouilloux B, Perrot JL, Labeille B, Douchet C, Cambazard F. Confocal microscopy for healthy and pathological nail. J Eur Acad Dermatol Venereol. 2014;28:853–8.
Goettmann S, Zaraa I, Moulonguet I. Nail lichen planus: epidemiological, clinical, pathological, therapeutic and prognosis study of 67 cases. J Eur Acad Dermatol Venereol. 2012;26:1304–9.
Iorizzo M. Nail lichen planus – a possible new indication for oral alitretinoin. J Eur Acad Dermatol Venereol. 2016;30(3):509–10.
Juhlin L, Baran R. Longitudinal melanonychia after healing of lichen planus. Acta Derm Venereol. 1989;69:338–9.
Kato Y, Hayakawa R, Shiraki R, Ozeki K. A case of lichen planus caused by mercury allergy. Br J Dermatol. 2003;148:1268–9.
Khullar G, Handa S, De D, Saikia UN. Bullous lichen planus of the nails. JAMA Dermatol. 2015;151:674–5.
Nakamura R, Broce AA, Palencia DP, Ortiz NI, Leverone A. Dermatoscopy of nail lichen planus. Int J Dermatol. 2013;52:684–7.
Nishizawa A, Satoh T, Yokozeki H. Close association between metal allergy and nail lichen planus: detection of causative metals in nail lesions. J Eur Acad Dermatol Venereol. 2013;27(2):e231–4.
Pandhi D, Singal A, Bhattacharya SN. Lichen planus in childhood: a series of 316 patients. Pediatr Dermatol. 2014;31:59–67.
Pinter A, Pätzold S, Kaufmann R. Lichen planus of nails – successful treatment with Alitretinoin. J Dtsch Dermatol Ges. 2011;9:1033–4.
Piraccini BM, Saccani E, Starace M, Balestri R, Tosti A. Nail lichen planus: response to treatment and long term follow-up. Eur J Dermatol. 2010;20:489–96.
Piraccini BM, Bruni F, Starace M. Dermoscopy of non-skin cancer nail disorders. Dermatol Ther. 2012;25:594–602.
Renker T, Haneke E, Röcken C, Borradori L. Systemic light-chain amyloidosis revealed by progressive nail involvement, diffuse alopecia and sicca syndrome: report of an unusual case with a review of the literature. Dermatol. 2014;228:97–102.
Richert B, André J. Trachyonychia: a clinical and histological study of 22 cases. J Eur Acad Dermatol Venereol. 1999;12:126.
Sanli H, Arat M, Oskay T, Gürman G. Evaluation of nail involvement in patients with chronic cutaneous graft versus host disease: a single-center study from Turkey. Int J Dermatol. 2004;43:176–80.
Scalf LA, Fowler JF Jr, Morgan KW, Looney SW. Dental metal allergy in patients with oral, cutaneous, and genital lichenoid reactions. Am J Contact Dermat. 2001;12(3):146–50.
Scher RK, Fischbein R, Ackerman AB. Twenty-nail dystrophy: A variant of lichen planus. Arch Dermatol. 1978;114:612–3.
Shiohara T, Kano Y. Lichen planus. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. London: Mosby Elsevier; 2008. p. 511.
Suarez SM, Scher RK. Idiopathic atrophy of the nails: a possible hereditary association. Pediatr Dermatol. 1990;7:39–41.
Tosti A, Peluso AM, Fanti PA, Piraccini BM. Nail lichen planus: clinical and pathologic study of twenty-four patients. J Am Acad Dermatol. 1993;28:724–30.
Tosti A, Bardazzi F, Piraccini BM, et al. Idiopathic trachyonychia (twenty-nail dystrophy): a pathological study of 23 patients. Br J Dermatol. 1994;131:866–72.
Tosti A, Piraccini BM, Fanti PA, Bardazzi F, Di Landro A. Idiopathic atrophy of the nails: clinical and pathological study of 2 cases. Dermatology. 1995;190:116–8.
Tosti A, Ghetti E, Piraccini BM, Fanti PA. Lichen planus of the nails and fingertips. Eur J Dermatol. 1998;8:447–8.
Tosti A, Piraccini BM, Cameli N. Nail changes in lichen planus may resemble those of yellow nail syndrome. Br J Dermatol. 2000;142:848–9.
Tosti A, Piraccini BM, Cambiaghi S, Jorizzo M. Nail lichen planus in children: clinical features, response to treatment, and long-term follow-up. Arch Dermatol. 2001;137:1027–32.
Yokozeki H, Niiyama S, Nishioka K. Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with gold allergy. Br J Dermatol. 2005;152(5):1087–9.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
7.1 Supplementary Electronic Material
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Piraccini, B.M., Starace, M., Misciali, C., Fanti, P.A. (2018). Nail Unit Lichen Planus. In: Rubin, A.I., Jellinek, N.J., Daniel, C.R., Scher, R.K. (eds) Scher and Daniel’s Nails. Springer, Cham. https://doi.org/10.1007/978-3-319-65649-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-65649-6_7
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-65647-2
Online ISBN: 978-3-319-65649-6
eBook Packages: MedicineMedicine (R0)