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Aneurysm Treatment with Flow Diverters

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Cerebrovascular and Endovascular Neurosurgery
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Abstract

Flow diversion is a novel treatment for brain aneurysms that works by redirecting blood flow away from the aneurysm. By placing a stent in the parent vessel that covers more of the opening to the aneurysm with mesh than traditional stents, blood flow is redirected away from entering the aneurysm. The blood within the aneurysm then stagnates and undergoes thrombosis. Over time, a new endothelium develops across the neck, thereby reconstructing the parent vessel and curing the aneurysm. There are several known rare complications associated with this treatment modality and a growing understanding of how to avoid them. For one, ischemic events can occur and are related to either thromboembolism or perforator vessel occlusion. Also, hemorrhagic events can occur unpredictably at distant sites, or even from the target aneurysm. Finally, aneurysm persistence following treatment is an infrequent event but can occur and place patients at risk for future aneurysm rupture. Flow diversion is an effective method to treat many types of brain aneurysms, and a focus on complication avoidance is necessary to make it an even safer option for patients.

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References

  1. Petr O, Brinjikji W, Cloft H, Kallmes D, Lanzino G. Current trends and results of endovascular treatment of unruptured intracranial aneurysms at a single institution in the flow-diverter era. Am J Neuroradiol. 2016;37(6):1106–13.

    Article  CAS  PubMed  Google Scholar 

  2. Zhou G, Su M, Zhu Y-Q, Li M-H. Efficacy of flow-diverting devices for cerebral aneurysms: a systematic review and meta-analysis. World Neurosurg. 2016;85:252–62.

    Article  PubMed  Google Scholar 

  3. Brinjikji W, Murad MH, Lanzino G, Cloft HJ, Kallmes DF. Endovascular treatment of intracranial aneurysms with flow diverters a meta-analysis. Stroke. 2013;44(2):442–7.

    Article  PubMed  Google Scholar 

  4. Pierot L, Costalat V, Moret J, et al. Safety and efficacy of aneurysm treatment with WEB: results of the WEBCAST study. J Neurosurg. 2016;124(5):1250–6.

    Article  PubMed  Google Scholar 

  5. Becske T, Kallmes DF, Saatci I, et al. Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial. Radiology. 2013;267(3):858–68.

    Article  PubMed  Google Scholar 

  6. Walcott BP, Stapleton CJ, Choudhri O, Patel AB. Flow diversion for the treatment of intracranial aneurysms. JAMA Neurol. 2016;73(8):1002–8.

    Article  PubMed  Google Scholar 

  7. Walcott BP, Pisapia JM, Nahed BV, Kahle KT, Ogilvy CS. Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysms. J Clin Neurosci. 2011;18(7):891–4.

    Article  PubMed  Google Scholar 

  8. Chalouhi N, Starke RM, Yang S, et al. Extending the indications of flow diversion to small, unruptured, saccular aneurysms of the anterior circulation. Stroke. 2014;45(1):54–8.

    Article  PubMed  Google Scholar 

  9. Leon MB, Baim DS, Popma JJ, et al. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. N Engl J Med. 1998;339(23):1665–71.

    Article  CAS  PubMed  Google Scholar 

  10. Topol EJ, Investigators E. Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade. Lancet. 1998;352(9122):87–92.

    Article  Google Scholar 

  11. Montalescot G, Wiviott SD, Braunwald E, et al. Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial. Lancet. 2009;373(9665):723–31.

    Article  CAS  PubMed  Google Scholar 

  12. Brasiliense LB, Stanley MA, Grewal SS, et al. Silent ischemic events after pipeline embolization device: a prospective evaluation with MR diffusion-weighted imaging. J Neurointerv Surg. 2016;8(11):1136–9. https://doi.org/10.1136/neurintsurg-2015-012091.

    Article  PubMed  Google Scholar 

  13. Iosif C, Camilleri Y, Saleme S, et al. Diffusion-weighted imaging–detected ischemic lesions associated with flow-diverting stents in intracranial aneurysms: safety, potential mechanisms, clinical outcome, and concerns. J Neurosurg. 2015;122(3):627–36.

    Article  PubMed  Google Scholar 

  14. Heller RS, Dandamudi V, Lanfranchi M, Malek AM. Effect of antiplatelet therapy on thromboembolism after flow diversion with the pipeline embolization device: clinical article. J Neurosurg. 2013;119(6):1603–10.

    Article  PubMed  Google Scholar 

  15. Mega JL, Close SL, Wiviott SD, et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON–TIMI 38 trial: a pharmacogenetic analysis. Lancet. 2010;376(9749):1312–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Brinjikji W, Lanzino G, Cloft H, Siddiqui A, Hanel R, Kallmes DF. Platelet testing is associated with worse clinical outcomes for patients treated with the pipeline embolization device. Am J Neuroradiol. 2015;36(11):2090–5.

    Article  CAS  PubMed  Google Scholar 

  17. Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357(20):2001–15.

    Article  CAS  PubMed  Google Scholar 

  18. Kallmes DF, Ding YH, Dai D, Kadirvel R, Lewis DA, Cloft HJ. A new endoluminal, flow-disrupting device for treatment of saccular aneurysms. Stroke. 2007;38(8):2346–52.

    Article  PubMed  Google Scholar 

  19. Siddiqui AH, Abla AA, Kan P, et al. Panacea or problem: flow diverters in the treatment of symptomatic large or giant fusiform vertebrobasilar aneurysms: clinical article. J Neurosurg. 2012;116(6):1258–66.

    Article  PubMed  Google Scholar 

  20. Puffer RC, Kallmes DF, Cloft HJ, Lanzino G. Patency of the ophthalmic artery after flow diversion treatment of paraclinoid aneurysms: clinical article. J Neurosurg. 2012;116(4):892–6.

    Article  PubMed  Google Scholar 

  21. Griessenauer CJ, Ogilvy CS, Foreman PM, et al. Pipeline embolization device for small paraophthalmic artery aneurysms with an emphasis on the anatomical relationship of ophthalmic artery origin and aneurysm. J Neurosurg. 2016;125(6):1352–9.

    Article  PubMed  Google Scholar 

  22. Raz E, Shapiro M, Becske T, et al. Anterior choroidal artery patency and clinical follow-up after coverage with the pipeline embolization device. Am J Neuroradiol. 2015;36(5):937–42.

    Article  CAS  PubMed  Google Scholar 

  23. Levitt M, Park M, Albuquerque F, Moon K, Kalani M, McDougall C. Posterior inferior cerebellar artery patency after flow-diverting stent treatment. Am J Neuroradiol. 2016;37(3):487–9.

    Article  CAS  PubMed  Google Scholar 

  24. Rangel-Castilla L, Munich SA, Jaleel N, et al. Patency of anterior circulation branch vessels after pipeline embolization: longer-term results from 82 aneurysm cases. J Neurosurg. 2017;126(4):1064–9.

    Article  PubMed  Google Scholar 

  25. Chalouhi N, Daou B, Kung D, et al. Fate of the ophthalmic artery after treatment with the pipeline embolization device. Neurosurgery. 2015;77(4):581–4.

    Article  PubMed  Google Scholar 

  26. Brinjikji W, Kallmes DF, Cloft H, Lanzino G. Patency of the anterior choroidal artery after flow-diversion treatment of internal carotid artery aneurysms. Am J Neuroradiol. 2015;36(3):537–41.

    Article  CAS  PubMed  Google Scholar 

  27. Brinjikji W, Lanzino G, Cloft HJ, Kallmes DF. Patency of the posterior communicating artery after flow diversion treatment of internal carotid artery aneurysms. Clin Neurol Neurosurg. 2014;120:84–8.

    Article  PubMed  Google Scholar 

  28. Vedantam A, Rao VY, Shaltoni HM, Mawad ME. Incidence and clinical implications of carotid branch occlusion following treatment of internal carotid artery aneurysms with the pipeline embolization device. Neurosurgery. 2015;76(2):173–8.

    Article  PubMed  Google Scholar 

  29. Durst CR, Starke RM, Clopton D, et al. Endovascular treatment of ophthalmic artery aneurysms: ophthalmic artery patency following flow diversion versus coil embolization. J Neurointerv Surg. 2016;8(9):919–22. https://doi.org/10.1136/neurintsurg-2015-011887.

    Article  PubMed  Google Scholar 

  30. Daou B, Valle-Giler EP, Chalouhi N, et al. Patency of the posterior communicating artery following treatment with the pipeline embolization device. J Neurosurg. 2017;126(2):564–9.

    Article  PubMed  Google Scholar 

  31. Shuaib A, Butcher K, Mohammad AA, Saqqur M, Liebeskind DS. Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target. Lancet Neurol. 2011;10(10):909–21.

    Article  PubMed  Google Scholar 

  32. Natarajan SK, Lin N, Sonig A, et al. The safety of pipeline flow diversion in fusiform vertebrobasilar aneurysms: a consecutive case series with longer-term follow-up from a single US center. J Neurosurg. 2016;125(1):111–9.

    Article  PubMed  Google Scholar 

  33. Colby GP, Lin L-M, Caplan JM, et al. Immediate procedural outcomes in 44 consecutive pipeline flex cases: the first North American single-center series. J Neurointerv Surg. 2016;8(7):702–9. https://doi.org/10.1136/neurintsurg-2015-011894.

    Article  PubMed  Google Scholar 

  34. Yavuz K, Geyik S, Saatci I, Cekirge H. Endovascular treatment of middle cerebral artery aneurysms with flow modification with the use of the pipeline embolization device. Am J Neuroradiol. 2014;35(3):529–35.

    Article  CAS  PubMed  Google Scholar 

  35. Kallmes DF, Hanel R, Lopes D, et al. International retrospective study of the pipeline embolization device: a multicenter aneurysm treatment study. Am J Neuroradiol. 2015;36(1):108–15.

    Article  CAS  PubMed  Google Scholar 

  36. Shobayashi Y, Tateshima S, Kakizaki R, Sudo R, Tanishita K, Viñuela F. Intra-aneurysmal hemodynamic alterations by a self-expandable intracranial stent and flow diversion stent: high intra-aneurysmal pressure remains regardless of flow velocity reduction. J Neurointerv Surg. 2013;5(Suppl 3):iii38–42.

    Article  PubMed  Google Scholar 

  37. Kulcsár Z, Houdart E, Bonafe A, et al. Intra-aneurysmal thrombosis as a possible cause of delayed aneurysm rupture after flow-diversion treatment. Am J Neuroradiol. 2011;32(1):20–5.

    Article  PubMed  Google Scholar 

  38. Cebral J, Mut F, Raschi M, et al. Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment. Am J Neuroradiol. 2011;32(1):27–33.

    Article  CAS  PubMed  Google Scholar 

  39. Walcott BP, Reinshagen C, Stapleton CJ, et al. Predictive modeling and in vivo assessment of cerebral blood flow in the management of complex cerebral aneurysms. J Cereb Blood Flow Metab. 2016;36(6):998–1003. https://doi.org/10.1177/0271678X16641125.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Lin N, Brouillard AM, Krishna C, et al. Use of coils in conjunction with the pipeline embolization device for treatment of intracranial aneurysms. Neurosurgery. 2015;76(2):142–9.

    Article  PubMed  Google Scholar 

  41. Cruz J, Chow M, O'Kelly C, et al. Delayed ipsilateral parenchymal hemorrhage following flow diversion for the treatment of anterior circulation aneurysms. Am J Neuroradiol. 2012;33(4):603–8.

    Article  CAS  PubMed  Google Scholar 

  42. Hu YC, Deshmukh VR, Albuquerque FC, et al. Histopathological assessment of fatal ipsilateral intraparenchymal hemorrhages after the treatment of supraclinoid aneurysms with the pipeline embolization device: report of 3 cases. J Neurosurg. 2014;120(2):365–74.

    Article  PubMed  Google Scholar 

  43. Yavuz K, Geyik S, Saatci I, Cekirge HS. Endovascular treatment of middle cerebral artery aneurysms with flow modification with the use of the pipeline embolization device. AJNR Am J Neuroradiol. Mar 2014;35(3):529–535.

    Google Scholar 

  44. Chiu AH, Cheung AK, Wenderoth JD, et al. Long-Term Follow-Up Results following Elective Treatment of Unruptured Intracranial Aneurysms with the Pipeline Embolization Device. AJNR Am J Neuroradiol. Sep 2015;36(9):1728–1734.

    Google Scholar 

  45. Shapiro M, Becske T, Nelson PK. Learning from failure: persistence of aneurysms following pipeline embolization. J Neurosurg. May 2016:1–8.

    Google Scholar 

  46. Becske T, Kallmes DF, Saatci I, et al. Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial. Radiology. Jun 2013;267(3):858–868.

    Google Scholar 

  47. Zanaty M, Chalouhi N, Starke RM, et al. Failure of the Pipeline Embolization Device in Posterior Communicating Artery Aneurysms Associated with a Fetal Posterior Cerebral Artery. Case Rep Vasc Med. 2016.

    Google Scholar 

  48. Kan P, Duckworth E, Puri A, Velat G, Wakhloo A. Treatment failure of fetal posterior communicating artery aneurysms with the pipeline embolization device. J Neurointerv Surg. Sept 2016;8(9):945–8.

    Google Scholar 

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Correspondence to William J. Mack .

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Walcott, B.P., Chang, KE., Babadjouni, R., Mack, W.J. (2018). Aneurysm Treatment with Flow Diverters. In: Gandhi, C., Prestigiacomo, C. (eds) Cerebrovascular and Endovascular Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-65206-1_26

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  • DOI: https://doi.org/10.1007/978-3-319-65206-1_26

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