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Drug Metabolism in Liver Failure

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Abbreviations

PK:

Pharmacokinetics

PD:

Pharmacodynamics

Clh :

Hepatic clearance

Eh :

Hepatic extraction

Clint :

Intrinsic clearance

Fu :

Fraction unbound

Q:

Hepatic blood flow

Vd :

Volume of distribution

CYP:

Cytochrome

GABA:

Gamma-aminobutyric acid

t1/2 :

Half-life

AUC:

Area-under-the-curve

Cmax :

Maximum concentration

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Authors and Affiliations

  1. Cleveland Clinic, Cleveland, OH, USA

    Simon W. Lam PharmD, FCCM

Authors
  1. Simon W. Lam PharmD, FCCM
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Corresponding author

Correspondence to Simon W. Lam PharmD, FCCM .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Columbia University Medical Center, New York, New York, USA

    Gebhard Wagener

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Lam, S.W. (2018). Drug Metabolism in Liver Failure. In: Wagener, G. (eds) Liver Anesthesiology and Critical Care Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-64298-7_5

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  • DOI: https://doi.org/10.1007/978-3-319-64298-7_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-64297-0

  • Online ISBN: 978-3-319-64298-7

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