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Melanoma

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Abstract

Melanomas are malignant tumors arising from pigment cells: melanocytes. They arise from the neural crest, a transitory embryological structure at the dorsal borders of the neural plate.

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References

  1. Moxley KM, Fader AN, Rose PG, Case AC, Mutch DG, Berry E. Malignant melanoma of the vulva: an extension of cutaneous melanoma? Gynecol Oncol. 2011;122:612–7.

    Article  CAS  Google Scholar 

  2. Mihajlovic M, Vlajkovic S, Jovanovic P, Stefanovic V. Primary mucosal melanomas: a comprehensive review. Int J Clin Exp Pathol. 2012;5:739–53.

    PubMed  PubMed Central  Google Scholar 

  3. Weinstock MA. Malignant melanoma of the vulva and vagina in the United States: patterns of incidence and population based estimates of survival. Am J Obstet Gynecol. 1994;171:1225–30.

    Article  CAS  Google Scholar 

  4. Rosamilia LL, Scwartz JL, Lowe L. Vulvar melanoma in a 10 years old girl in association with lichen sclerosus. J Am Acad Dermatol. 2006;54(suppl I):S52–3.

    Article  Google Scholar 

  5. La Spina M, Meli MC, De Pasquale R, Perrotta RE. Vulvar melanoma associated with lichen sclerosus in a child: case report and literature review. Pediatr Dermatol. 2016;33:190–4.

    Article  Google Scholar 

  6. Sugiyama VE, Chan JK, Shin JY, Berek JS, Osann K, Kapp DS. VUlvar melanoma: a multivariable analysis of 644 patients. Obstet Gynecol. 2007;110:296–301.

    Article  Google Scholar 

  7. Omholt K, Grafstrom E, Kanter Lewenson L, Hansson J, Ragnarsson Olding BK. KIT pathway alterations in mucosal melanomas of the vulva and other sites. Clin Cancer Res. 2011;17:3933–42.

    Article  CAS  Google Scholar 

  8. Yélamos O, Merkel EA, Sholl LM, Zhang B, et al. Nonoverlapping clinical and mutational patterns in melanomas from the female genital tract and atypical genital nevi. J Invest Dermatol. 2016;136(9):1858–65.

    Article  Google Scholar 

  9. Carlson JA, Mu XC, Slominski A, Weismann K, Crowson AN, Malfetano J. Melanocytic proliferations associated with lichen sclerosus. Arch Dermatol. 2002;138:77–87.

    Article  Google Scholar 

  10. Ragnarsson olding BK, Kanter Lewensohn LR, Lagerlof B, Nilsson BR, Ringborg UK. Malignant melanoma of the vulva in a nationwide, 25 year study of 219 swedish females: clinical observation and histopathologic features. Cancer. 1999;86:1273–84.

    Article  CAS  Google Scholar 

  11. Kerley SW, Blute ML, Keeney GL. Multifocal malignant melanoma arising in vesicovaginal metastasis. Arch Pathol Lab. 1991;115:950–2.

    CAS  Google Scholar 

  12. Debarbieux S, Perrot JL, Erfan N, Ronger-Savlé S, Labeille B, Cinotti E, Depaepe L, Cardot-Leccia N, Lacour JP, Thomas L, Bahadoran P, Groupe d’Imagerie Cutanée non invasive de la Société Française de Dermatologie. Reflectance confocal microscopy of mucosal pigmented macules: a review of 56 cases including 10 macular melanomas. Br J Dermatol. 2014;170(6):1276–84.

    Article  CAS  Google Scholar 

  13. Murzaku EC, Penn LA, Hale CS, Keltz Pomeranz M, Polsky D. Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical and histopathological review. JAAD. 2014;71:1241–9.

    Article  Google Scholar 

  14. Mert I, Semaan A, Winer I, Morris RT, Ali Fehmi R. Vulvar/vaginal melanoma: an updated surveillance epidemiology and results database review, comparison with cutaneous melanoma and significance of racial disparities. Int J Gynecol Cancer. 2013;23:1118–25.

    Article  Google Scholar 

  15. Spencer KR, Mehnert JM. Mucosal melanoma: epidemiology, biology and treatment. Cancer Treat Res. 2016;167:295–320.

    Article  Google Scholar 

  16. De Hullu JA, Hollema H, Hoekstra HJ. Vulvar melanomas: is there a role for sentinel lymph node biopsy? Cancer. 2002;94:486–91.

    Article  Google Scholar 

  17. Pstow MA, Hamid O, Carvajal RD. Mucosal melanoma: pathogenesis, clinical behavior, and management. Curr Oncol Rep. 2012;14:441–8.

    Article  Google Scholar 

  18. Creasman WT, Phillips JL, Menck HR. A survey of hospital management practices for vulvar melanoma. J Am Coll Surg. 1999;188(6):670–5.

    Article  CAS  Google Scholar 

  19. Larkin J, Hodi FS, Wolchok JD. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373:23–34.

    Article  Google Scholar 

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© 2019 Springer International Publishing AG, part of Springer Nature

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Ronger Savle, S. (2019). Melanoma. In: Bornstein, J. (eds) Vulvar Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-61621-6_41

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  • DOI: https://doi.org/10.1007/978-3-319-61621-6_41

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-61620-9

  • Online ISBN: 978-3-319-61621-6

  • eBook Packages: MedicineMedicine (R0)

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