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Gastro-oesophageal Reflux and Cow’s Milk Allergy

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Abstract

Gastro-esophageal reflux disease (GERD) and cow’s milk allergy protein (CMPA) and are both common disorders in childhood, mainly infancy, and several studies have hypothesised a causal relationship between them, suggesting that at least in a subgroup of infants GERD is attributable to CMA. In children with CMPA, a neuroimmune interactions provoked by cow’s milk challenge might induce gastric motor abnormalities and in turn increase the number of reflux episodes. Studies assessing the relationship between the two conditions have shown an association ranging between 16 and 55%, which is far beyond from that expected from pure coexistence. Therefore, a possible concomitant CMPA, mainly in those infants and children with GERD unresponsive to medical treatment data, should be highly considered. Current ESPGHAN-NASPGHAN guidelines already suggest a short trial cow’s milk free diet in those infants with chronic regurgitation unresponsive to medical therapy, vomiting and failure to thrive.

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Authors and Affiliations

  1. Department of Paediatric Gastroenterology, Division of Neurogastroenterology and Motility, ICH University College of London, Great Ormond Street Hospital for Children, London, UK

    Francesco Valitutti, Anna Rybak & Osvaldo Borrelli

Authors
  1. Francesco Valitutti
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  2. Anna Rybak
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  3. Osvaldo Borrelli
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Corresponding author

Correspondence to Osvaldo Borrelli .

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Editors and Affiliations

  1. Universitair Ziekenhuis Brussel, Kidz Health Castle, Brussels, Belgium

    Yvan Vandenplas

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Valitutti, F., Rybak, A., Borrelli, O. (2017). Gastro-oesophageal Reflux and Cow’s Milk Allergy. In: Vandenplas, Y. (eds) Gastroesophageal Reflux in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-60678-1_14

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  • DOI: https://doi.org/10.1007/978-3-319-60678-1_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60677-4

  • Online ISBN: 978-3-319-60678-1

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