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Early Purkinje Cell Development and the Origins of Cerebellar Patterning

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Development of the Cerebellum from Molecular Aspects to Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

This chapter explores the mechanisms that regulate Purkinje cell neurogenesis, revealing the finely timed contribution of many regulatory genes in the control of PC progenitor specification, proliferation, subtype differentiation, migration, and survival from the cerebellar primordium to the end of prenatal embryogenesis, discussing some of the key molecules involved and the ways they combine to generate the complex adult cerebellar architecture.

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Acknowledgments

The authors’ research is funded through grants provided by the Italian Telethon Foundation (to GGC) and by the Italian Ministry of Health (to OC).

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Authors and Affiliations

  1. Università Vita-Salute San Raffaele, Via Olgettina 58, 20132, Milan, Italy

    Filippo Casoni, Ottavio Cremona & G. Giacomo Consalez

  2. Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

    Filippo Casoni, Laura Croci, Ottavio Cremona & G. Giacomo Consalez

  3. Department of Cell Biology and Anatomy, and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada

    Richard Hawkes

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  1. Filippo Casoni
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  2. Laura Croci
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  3. Ottavio Cremona
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  4. Richard Hawkes
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  5. G. Giacomo Consalez
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Correspondence to Richard Hawkes or G. Giacomo Consalez .

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  1. Department of Human Anatomy and Cell Science, The Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada

    Hassan Marzban

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Casoni, F., Croci, L., Cremona, O., Hawkes, R., Consalez, G.G. (2017). Early Purkinje Cell Development and the Origins of Cerebellar Patterning. In: Marzban, H. (eds) Development of the Cerebellum from Molecular Aspects to Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-59749-2_4

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