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Origin and Function of the Renal Stroma in Health and Disease

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Kidney Development and Disease

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 60))

Abstract

The renal stroma is defined as a heterogeneous population of cells that serve both as a supportive framework and as a source of specialized cells in the renal capsule, glomerulus, vasculature, and interstitium. In this chapter, we review published evidence defining what, where, and why stromal cells are important. We describe the functions of the renal stroma andhow stromal derivatives are crucial for normal kidney function. Next, we review the specification of stromal cells from the Osr1+ intermediate mesoderm and T+ presomitic mesoderm during embryogenesis and stromal cell differentiation. We focus on stromal signaling mechanisms that act in both a cell and non-cell autonomous manner in communication with the nephron progenitor and ureteric lineages. To conclude, stromal cells and the contribution of stromal cells to renal fibrosis and chronic kidney disease are described.

Christopher J. Rowan and Sepideh Sheybani-Deloui: These authors contributed equally to this work.

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Acknowledgements

This work was supported by grants from the Canadian Institute of Health Research, the Kidney Foundation of Canada and the Canada Research Chairs Program (to NDR), the Natural Sciences and Engineering Research Council of Canada (to SS), and the Research Training Centre at The Hospital for Sick Children (to CR).

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    Authors and Affiliations

    1. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada

      Christopher J. Rowan, Sepideh Sheybani-Deloui & Norman D. Rosenblum

    2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

      Christopher J. Rowan & Norman D. Rosenblum

    3. Department of Physiology, University of Toronto, Toronto, ON, Canada

      Sepideh Sheybani-Deloui & Norman D. Rosenblum

    4. Division of Nephrology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada

      Norman D. Rosenblum

    5. Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay St., Rm 16-9-706, Toronto, ON, M5G 0A4, Canada

      Norman D. Rosenblum

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    Correspondence to Norman D. Rosenblum .

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    1. Department of Pediatrics, The University of Texas Health Science Center at Houston, Houston, TX, USA

      Rachel K. Miller

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    Rowan, C.J., Sheybani-Deloui, S., Rosenblum, N.D. (2017). Origin and Function of the Renal Stroma in Health and Disease. In: Miller, R. (eds) Kidney Development and Disease. Results and Problems in Cell Differentiation, vol 60. Springer, Cham. https://doi.org/10.1007/978-3-319-51436-9_8

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