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Opioid-Induced Hyperalgesia After Surgery: Clinical Relevance

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Total Intravenous Anesthesia and Target Controlled Infusions

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Abstract

For decades opioids have been used to treat chronic pain as well as perioperative pain. More recently, the phenomenon of opioid-induced hyperalgesia (OIH) was introduced in the literature: the demonstration of diffuse hyperalgesia after chronic exposure to morphine (or other opioids), OIH, was linked to evidence of central sensitization detected by changes in heat tolerance thresholds and temporal summation tests (Chu et al., J Pain 7(1):43–8, 2006; Compton et al., Drug Alcohol Depend 63(2):139–46, 2001; Chen et al., Pain 143(1–2):65–70, 2009; Woolf, Pain 152(3 Suppl.):S2–15, 2011). To date, preexisting OIH, in the perioperative period, has not been well reported in the anesthesia literature. However, experimental studies suggest that sensitivity to pain is greater in those animals who have been exposed to opioids perioperatively as compared to those who were unexposed animals (Laboureyras et al., Anesth Analg 109(2):623–31, 2009; Celerier et al., Anesthesiology 92(2):465–72, 2000; Rivat et al., Anesthesiology 96(2):381–91, 2002).

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Authors and Affiliations

  1. Maisonneuve Rosemont Hospital, CIUSSS de l’Est-de-l’ile-de-Montreal, 5414, Boulevard de l’Assomption, Montreal, QC, H1t2M4, Canada

    Philippe Richebe MD, PhD & Cyrip Rivat MD, PhD

  2. Department of Anesthesiology, University of Montreal, Montreal, QC, Canada

    Philippe Richebe MD, PhD & Cyrip Rivat MD, PhD

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  1. Philippe Richebe MD, PhD
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Correspondence to Philippe Richebe MD, PhD .

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  1. Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Anthony R. Absalom

  2. Department of Anesthesia, Harvard Medical School, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

    Keira P. Mason

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Richebe, P., Rivat, C. (2017). Opioid-Induced Hyperalgesia After Surgery: Clinical Relevance. In: Absalom, A., Mason, K. (eds) Total Intravenous Anesthesia and Target Controlled Infusions. Springer, Cham. https://doi.org/10.1007/978-3-319-47609-4_42

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