Abstract
E-cyanobacterium.org is an online platform providing tools for public sharing, annotation, analysis, and visualization of dynamical models and wet-lab experiments related to cyanobacteria. The platform is unique in integrating abstract mathematical models with a precise consortium-agreed biochemical description provided in a rule-based formalism. The general aim is to stimulate collaboration between experimental and computational systems biologists to achieve better understanding of cyanobacteria.
This work has been supported by the Czech National Infrastructure grant LM2015055 and by the Czech Science Foundation grant GA15-11089S.
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References
Ashburner, M., et al.: Gene ontology: tool for the unification of biology. Gene Ontology Consortium, Nat. Genet. 25(1), 25–29 (2000)
Bateman, A., et al.: Uniprot: a hub for protein information. Nucleic Acids Res. 43(D1), D204–D212 (2015)
Beard, D.A., et al.: CellML metadata standards, associated tools and repositories. Philos. Trans. R. Soc. Lond. A Math. Phys. Eng. Sci. 367(1895), 1845–1867 (2009)
Croft, D., et al.: The reactome pathway knowledgebase. Nucleic Acids Res. 42(D1), D472–D477 (2014)
Dada, J.O., et al.: SBRML: a markup language for associating systems biology data with models. Bioinformatics 26(7), 932–938 (2010)
Eaton, J.W., et al.: GNU Octave version 3.0.1 manual: a high-level interactive language for numerical computations. CreateSpace Independent Publishing Platform, Seattle (2009)
Harris, T.W., et al.: Wormbase: a comprehensive resource for nematode research. Nucleic Acids Res. 38(suppl 1), D463–D467 (2010)
Hertel, S., et al.: Revealing a two-loop transcriptional feedback mechanism in the cyanobacterial circadian clock. PLoS Comput. Biol. 9(3), 1–16 (2013)
Hoops, S., et al.: COPASI - a complex pathway simulator. Bioinformatics 22(24), 3067–3074 (2006)
Hucka, M., et al.: The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19(4), 524–531 (2003)
Jablonsky, J., et al.: Multi-level kinetic model explaining diverse roles of isozymes in prokaryotes. PLoS ONE 9(8), 1–8 (2014)
Kanehisa, M., et al.: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44(D1), D457–D462 (2016)
Kent, E., et al.: Condor-COPASI: high-throughput computing for biochemical networks. BMC Syst. Biol. 6(1), 1–13 (2012)
Keseler, I.M., et al.: EcoCyc: fusing model organism databases with systems biology. Nucleic Acids Res. 41(D1), D605–D612 (2013)
Klement, M., et al.: A comprehensive web-based platform for domain-specific biological models. Electron. Notes Theoret. Comput. Sci. 299, 61–67 (2013)
Klement, M., et al.: Biochemical space: a framework for systemic annotation of biological models. In: Proceedings of the 5th International Workshop on Interactions Between Computer Science and Biology (CS2Bio-14). Electronic Notes in Theoretical Computer Science, vol. 306, pp. 31–44 (2014)
Le Novère, N., et al.: Biomodels database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems. Nucleic Acids Res. 34, D689–D691 (2006)
Miyoshi, F., et al.: A mathematical model for the kai-protein-based chemical oscillator and clock gene expression rhythms in cyanobacteria. J. Biol. Rhythms 22(1), 69–80 (2007)
Olivier, B.G., et al.: Web-based kinetic modelling using jws online. Bioinformatics 20(13), 2143–2144 (2004)
Rizk, A., et al.: A general computational method for robustness analysis with applications to synthetic gene networks. Bioinformatics 25(12), i169–i178 (2009)
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Troják, M., Šafránek, D., Hrabec, J., Šalagovič, J., Romanovská, F., Červený, J. (2016). E-Cyanobacterium.org: A Web-Based Platform for Systems Biology of Cyanobacteria. In: Bartocci, E., Lio, P., Paoletti, N. (eds) Computational Methods in Systems Biology. CMSB 2016. Lecture Notes in Computer Science(), vol 9859. Springer, Cham. https://doi.org/10.1007/978-3-319-45177-0_20
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