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Multidisciplinary Management of Rectal Cancer pp 503–507Cite as

Are There Biochemical and Molecular Biological Factors to Distinguish the Rectal Cancer by the Colon Cancer?

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Abstract

Empirically, different strategies have evolved for the treatment of locally advanced colon cancer (surgery followed by adjuvant chemotherapy) compared to locally advanced rectal cancer (neoadjuvant radio- or radiochemotherapy followed by total mesorectal excision followed by adjuvant chemotherapy). These differences are mostly attributable to the anatomical situation which poses an increased risk of local recurrence in locally advanced rectal cancer compared to colon cancer. On the other hand, in the metastatic setting, the treatment strategies are very much the same for colon carcinomas and rectum carcinomas, and the clinical outcome is generally similar [8]. Based on differences that exist between the normal right and left colon with respect to embryonic origin (midgut vs. hindgut) and some histological features [7], the question was raised whether colon cancer can be distinguished from rectal cancer based on molecular and/or biochemical differences.

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Authors and Affiliations

  1. University Medicine Leipzig, University Cancer Center Leipzig (UCCL), Liebigstraße 20, 04103, Leipzig, Germany

    Ulrich T. Hacker

  2. Université Paris Descartes, 45 rue des Saints-Pères, Paris, 75006, France

    Pierre Laurent-Puig

Authors
  1. Ulrich T. Hacker
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  2. Pierre Laurent-Puig
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Correspondence to Ulrich T. Hacker .

Editor information

Editors and Affiliations

  1. Dept. of Radiation Oncology, Università Cattolica S Cuore, Rome, Italy

    Vincenzo Valentini

  2. Head, Div. Clinical Oncology Research, University Clinic Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Sachsen-Anhalt, Germany

    Hans-Joachim Schmoll

  3. Department of Surgery, Leiden Univ Med Ctr, Leiden, The Netherlands

    Cornelis J. H. van de Velde

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Hacker, U.T., Laurent-Puig, P. (2018). Are There Biochemical and Molecular Biological Factors to Distinguish the Rectal Cancer by the Colon Cancer?. In: Valentini, V., Schmoll, HJ., van de Velde, C. (eds) Multidisciplinary Management of Rectal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-43217-5_59

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  • DOI: https://doi.org/10.1007/978-3-319-43217-5_59

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43215-1

  • Online ISBN: 978-3-319-43217-5

  • eBook Packages: MedicineMedicine (R0)

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