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Design and Applications of Nanoparticles in Biomedical Imaging pp 299–314Cite as

Nanoparticles for Ultrasound-Guided Imaging of Cell Implantation

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Abstract

Regenerative medicine uses stem cells to repair damaged tissue. Imaging plays a key role in this process because imaging can reveal the location of cells and how they are interacting with the surrounding tissue. Ultrasound imaging is particularly powerful because it offers excellent temporal and spatial resolution and is ubiquitously present at low cost. Here, we explain different types of ultrasound imaging in tandem with stem cell therapy. The two main classes are direct imaging that labels a stem cell with an exogenous contrast agent and indirect imaging in which a reporter gene expresses a protein that can then be targeted with a contrast agent as substrate. We also describe photoacoustic imaging as one of the latest techniques for increasing acoustic contrast in imaging. Finally, we close with some perspectives on growth and needs in the field.

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Author information

Authors and Affiliations

  1. Department of NanoEngineering, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA, 92093-0448, USA

    James Hartanto & Jesse V. Jokerst

Authors
  1. James Hartanto
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  2. Jesse V. Jokerst
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Corresponding author

Correspondence to Jesse V. Jokerst .

Editor information

Editors and Affiliations

  1. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Jeff W.M. Bulte

  2. Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Michel M.J. Modo

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Hartanto, J., Jokerst, J.V. (2017). Nanoparticles for Ultrasound-Guided Imaging of Cell Implantation. In: Bulte, J., Modo, M. (eds) Design and Applications of Nanoparticles in Biomedical Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-42169-8_14

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