Abstract
In the post-transplant setting, the differential diagnosis of cutaneous lesions, particularly those with a dense dermal infiltrate, includes graft-versus-host disease (GVHD), infection, drug reaction, and leukemia cutis. Myeloid leukemia may pose a particular problem in that there is loss of key myeloid markers which help distinguish the blasts. Further complicating the picture are T-cell malignancies with epidermotropism and immunohistologic markers which may overlap with those found in GVHD. In this chapter, we present a case of leukemia cutis and discuss the potential pitfalls, such as cases of cellular rich phase of GVHD with increased numbers of dermal monocytes.
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Robin, A.J., Yeung, C.C.S. (2019). Leukemia Cutis and Hematologic Malignancies with Cutaneous Manifestation. In: Yeung, C., Shulman, H. (eds) Pathology of Graft vs. Host Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-42099-8_5
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DOI: https://doi.org/10.1007/978-3-319-42099-8_5
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