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UTI and VUR

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Pediatric Urogenital Radiology

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Urinary tract infections (UTIs) are one of the most common bacterial infections in children (Spencer et al. 2010). Pediatric uroradiologists are frequently confronted with affected children due to the fact that UTI might be the only symptom of renal malformations or abnormalities of the urinary tract.

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Literature

  • American Academy of Pediatrics, C. o. Q. I., Subcommittee on Urinary Tract Infection (2011) Urinary Tract Infection: Clinical Practice Guideline for the Diagnosis and Management of the Initial UTI in Febrile Infants and Children 2 to 24 Months. Pediatrics 128(3):595–610

    Article  Google Scholar 

  • American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection (1999) Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics 103(4 Pt 1):843–852

    Google Scholar 

  • Ammenti A, Cataldi L et al (2012) Febrile urinary tract infections in young children: recommendations for the diagnosis, treatment and follow-up. Acta Paediatr 101(5):451–457

    Article  PubMed  Google Scholar 

  • Austenfeld MS, Snow BW (1988) Complications of pregnancy in women after reimplantation for vesicoureteral reflux. J Urol 140(5 Pt 2):1103–1106

    Article  PubMed  CAS  Google Scholar 

  • Austin PF, Bauer SB et al (2014) The Standardization of Terminology of Lower Urinary Tract Function in Children and Adolescents: Update Report from the Standardization Committee of the International Children’s Continence Society. J Urol 191(6):1863–1865

    Article  PubMed  Google Scholar 

  • Bailey RR (1979) Vesicoureteric Reflux in Healthy Infants and Children. In: Hodson P, Kincaid-Smith P (eds) Reflux Nephropathy. Masson Publishing SA, New York

    Google Scholar 

  • Becker GJ, Ihle BU et al (1986) Effect of pregnancy on moderate renal failure in reflux nephropathy. Br Med J (Clin Res Ed) 292(6523):796–798

    Article  CAS  Google Scholar 

  • Beetz R, Schulte-Wissermann H et al (1989) Long-term follow-up of children with surgically treated vesicorenal reflux: postoperative incidence of urinary tract infections, renal scars and arterial hypertension. Eur Urol 16(5):366–371

    Article  PubMed  CAS  Google Scholar 

  • Beetz R, Mannhardt W et al (2002) Long-term followup of 158 young adults surgically treated for vesicoureteral reflux in childhood: the ongoing risk of urinary tract infections. J Urol 168(2):704–707; discussion 707

    Article  PubMed  CAS  Google Scholar 

  • Benador D, Benador N et al (1997) Are younger children at highest risk of renal sequelae after pyelonephritis? Lancet 349(9044):17–19

    Article  PubMed  CAS  Google Scholar 

  • Bloomfield P, Hodson EM et al (2005) Antibiotics for acute pyelonephritis in children. Cochrane Database Syst Rev 1, CD003772

    Google Scholar 

  • Bonnin F, Lottmann H et al (2001) Scintigraphic screening for renal damage in siblings of children with symptomatic primary vesico-ureteric reflux. BJU Int 87(6):463–466

    Article  PubMed  CAS  Google Scholar 

  • Brandstrom P, Esbjorner E et al (2010a) The Swedish reflux trial in children: III. Urinary tract infection pattern. J Urol 184(1):286–291

    Article  PubMed  Google Scholar 

  • Brandstrom P, Neveus T et al (2010b) The Swedish reflux trial in children: IV. Renal damage. J Urol 184(1):292–297

    Article  PubMed  Google Scholar 

  • Buys H, Pead L et al (1994) Suprapubic aspiration under ultrasound guidance in children with fever of undiagnosed cause. BMJ 308(6930):690–692

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cascio S, Paran S et al (1999) Associated urological anomalies in children with unilateral renal agenesis. J Urol 162(3 Pt 2):1081–1083

    Article  PubMed  CAS  Google Scholar 

  • Cavagnaro F (2005) Urinary tract infection in childhood. Rev Chilena Infectol 22(2):161–168

    Article  PubMed  Google Scholar 

  • Cheng CH, Tsau YK et al (2006) Effective duration of antimicrobial therapy for the treatment of acute lobar nephronia. Pediatrics 117(1):e84–e89

    Article  PubMed  Google Scholar 

  • Coelho GM, Bouzada MC et al (2008) Risk factors for urinary tract infection in children with prenatal renal pelvic dilatation. J Urol 179(1):284–289

    Article  PubMed  Google Scholar 

  • Cohen SJ (1975) Ureterozystoneostomie: eine neue Antireflux-Technik. Akt Urol 6(1)

    Google Scholar 

  • Connolly LP, Treves ST et al (1997) Vesicoureteral reflux in children: incidence and severity in siblings. J Urol 157(6):2287–2290

    Article  PubMed  CAS  Google Scholar 

  • Contopoulos-Ioannidis DG, Giotis ND et al (2004) Extended-interval aminoglycoside administration for children: a meta-analysis. Pediatrics 114(1):e111–e118

    Article  PubMed  Google Scholar 

  • Coulthard MG, Verber I et al (2009) Can prompt treatment of childhood UTI prevent kidney scarring? Pediatr Nephrol 24(10):2059–2063

    Article  PubMed  Google Scholar 

  • Craig JC, Knight JF et al (1996) Effect of circumcision on incidence of urinary tract infection in preschool boys. J Pediatr 128(1):23–27

    Article  PubMed  CAS  Google Scholar 

  • Craig JC, Knight JF et al (1997) Vesicoureteric reflux and timing of micturating cystourethrography after urinary tract infection. Arch Dis Child 76(3):275–277

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Craig JC, Simpson JM et al (2009) Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med 361(18):1748–1759

    Article  PubMed  CAS  Google Scholar 

  • Craig JC, Williams GJ et al (2010) The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses. BMJ 340:c1594

    Article  PubMed  PubMed Central  Google Scholar 

  • Darge K (2008) Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations. Pediatr Radiol 38(1):54–63; quiz 126–7

    Article  PubMed  Google Scholar 

  • Darge K, Moeller RT et al (2005) Diagnosis of vesicoureteric reflux with low-dose contrast-enhanced harmonic ultrasound imaging. Pediatr Radiol 35(1):73–78

    Article  PubMed  Google Scholar 

  • De Paepe H, Renson C et al (2000) Pelvic-floor therapy and toilet training in young children with dysfunctional voiding and obstipation. BJU Int 85(7):889–893

    Article  PubMed  Google Scholar 

  • Deville WL, Yzermans JC et al (2004) The urine dipstick test useful to rule out infections. A meta-analysis of the accuracy. BMC Urol 4:4

    Article  PubMed  PubMed Central  Google Scholar 

  • Doganis D, Sinaniotis K (2009) Early antibiotic treatment of pyelonephritis in children is still mandatory. Pediatrics 123(1):e173–e174; author reply e174

    Article  PubMed  Google Scholar 

  • Doganis D, Siafas K et al (2007) Does early treatment of urinary tract infection prevent renal damage? Pediatrics 120(4):e922–e928

    Article  PubMed  Google Scholar 

  • Doganis D, Mavrikou M et al (2009) Timing of voiding cystourethrography in infants with first time urinary infection. Pediatr Nephrol 24(2):319–322

    Article  PubMed  Google Scholar 

  • Edwards D, Normand IC et al (1977) Disappearance of vesicoureteric reflux during long-term prophylaxis of urinary tract infection in children. Br Med J 2(6082):285–288

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Elder JS, Peters CA et al (1997) Pediatric Vesicoureteral Reflux Guidelines Panel summary report on the management of primary vesicoureteral reflux in children. J Urol 157(5):1846–1851

    Article  PubMed  CAS  Google Scholar 

  • Elder JS, Shah MB et al (2007) Part 3: Endoscopic injection versus antibiotic prophylaxis in the reduction of urinary tract infections in patients with vesicoureteral reflux. Curr Med Res Opin 23(Suppl 4):S15–S20

    Article  PubMed  Google Scholar 

  • Esbjorner E, Hansson S et al (2004) Management of children with dilating vesico-ureteric reflux in Sweden. Acta Paediatr 93(1):37–42

    Article  PubMed  CAS  Google Scholar 

  • Faust WC, Diaz M et al (2009) Incidence of post-pyelonephritic renal scarring: a meta-analysis of the dimercapto-succinic acid literature. J Urol 181(1):290–297; discussion 297–298

    Article  PubMed  Google Scholar 

  • Finnell SM, Carroll AE et al (2011) Technical Report--Diagnosis and Management of an Initial UTI in Febrile Infants and Young Children. Pediatrics 128(4):e749–e770

    PubMed  Google Scholar 

  • Friedman AA, Wolfe-Christensen C et al (2013) History of recurrent urinary tract infection is not predictive of abnormality on voiding cystourethrogram. Pediatr Surg Int 29(6):639–643

    Article  PubMed  Google Scholar 

  • Galanakis E, Bitsori M et al (2006) Urine interleukin-8 as a marker of vesicoureteral reflux in infants. Pediatrics 117(5):e863–e867

    Article  PubMed  Google Scholar 

  • Garin EH, Campos A et al (1998) Primary vesicoureteral reflux: review of current concepts. Pediatr Nephrol 12(3):249–256

    Article  PubMed  CAS  Google Scholar 

  • Garin EH, Olavarria F et al (2006) Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics 117(3):626–632

    Article  PubMed  Google Scholar 

  • Garin EH, Olavarria F et al (2007) Diagnostic significance of clinical and laboratory findings to localize site of urinary infection. Pediatr Nephrol 22(7):1002–1006

    Article  PubMed  Google Scholar 

  • Gaspari RJ, Dickson E et al (2005) Antibiotic resistance trends in paediatric uropathogens. Int J Antimicrob Agents 26(4):267–271

    Article  PubMed  CAS  Google Scholar 

  • Ghaemi S, Fesharaki RJ et al (2007) Late onset jaundice and urinary tract infection in neonates. Indian J Pediatr 74(2):139–141

    Article  PubMed  Google Scholar 

  • Gimpel C, Masioniene L et al (2010) Complications and long-term outcome of primary obstructive megaureter in childhood. Pediatr Nephrol 25(9):1679–1686

    Article  PubMed  Google Scholar 

  • Glauser MP, Meylan P et al (1987) The inflammatory response and tissue damage. The example of renal scars following acute renal infection. Pediatr Nephrol 1(4):615–622

    Article  PubMed  CAS  Google Scholar 

  • Gordon I, Barkovics M et al (2003) Primary vesicoureteric reflux as a predictor of renal damage in children hospitalized with urinary tract infection: a systematic review and meta-analysis. J Am Soc Nephrol 14(3):739–744

    Article  PubMed  Google Scholar 

  • Greenfield SP, Wan J (1996) Vesicoureteral reflux: practical aspects of evaluation and management. Pediatr Nephrol 10(6):789–794

    Article  PubMed  CAS  Google Scholar 

  • Greenfield SP, Chesney RW et al (2008) Vesicoureteral reflux: the RIVUR study and the way forward. J Urol 179(2):405–407

    Article  PubMed  Google Scholar 

  • Gregoir W (1962) Congenital vesico-ureteral reflux. Acta Urol Belg 30:286–300

    PubMed  CAS  Google Scholar 

  • Halevy R, Smolkin V et al (2004) Power Doppler ultrasonography in the diagnosis of acute childhood pyelonephritis. Pediatr Nephrol 19(9):987–991

    Article  PubMed  Google Scholar 

  • Haller M, Brandis M et al (2004) Antibiotic resistance of urinary tract pathogens and rationale for empirical intravenous therapy. Pediatr Nephrol 19(9):982–986

    Article  PubMed  Google Scholar 

  • Hansson S, Jodal U et al (1989a) Untreated asymptomatic bacteriuria in girls: II--Effect of phenoxymethylpenicillin and erythromycin given for intercurrent infections. BMJ 298(6677):856–859

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hansson S, Jodal U et al (1989b) Untreated bacteriuria in asymptomatic girls with renal scarring. Pediatrics 84(6):964–968

    PubMed  CAS  Google Scholar 

  • Hansson S, Dhamey M et al (2004) Dimercapto-succinic acid scintigraphy instead of voiding cystourethrography for infants with urinary tract infection. J Urol 172(3):1071–1073; discussion 1073–1074

    Article  PubMed  Google Scholar 

  • Herndon CD (2006) Antenatal hydronephrosis: differential diagnosis, evaluation, and treatment options. ScientificWorldJournal 6:2345–2365

    Article  PubMed  PubMed Central  Google Scholar 

  • Herndon CD, Kitchens DM (2009) The management of ureteropelvic junction obstruction presenting with prenatal hydronephrosis. ScientificWorldJournal 9:400–403

    Article  PubMed  PubMed Central  Google Scholar 

  • Hertle L, Becht E et al (1983) Universelle Ureterozystoneostomie nach der Psoas Hitch Technik: Indiaktion - Operationstechnik. Akt Urol 14:167–174

    Article  Google Scholar 

  • Herzog LW (1989) Urinary tract infections and circumcision. A case–control study. Am J Dis Child 143(3):348–350

    Article  PubMed  CAS  Google Scholar 

  • Hewitt IK, Zucchetta P et al (2008) Early treatment of acute pyelonephritis in children fails to reduce renal scarring: data from the Italian Renal Infection Study Trials. Pediatrics 122(3):486–490

    Article  PubMed  Google Scholar 

  • Hildebrand WL, Schreiner RL et al (1981) Suprapubic bladder aspiration in infants. Am Fam Physician 23(5):115–118

    PubMed  CAS  Google Scholar 

  • Hiraoka M, Hashimoto G et al (2003) Early treatment of urinary infection prevents renal damage on cortical scintigraphy. Pediatr Nephrol 18(2):115–118

    PubMed  Google Scholar 

  • Hoberman A, Wald ER (1997) Urinary tract infections in young febrile children. Pediatr Infect Dis J 16(1):11–17

    Article  PubMed  CAS  Google Scholar 

  • Hoberman A, Chao HP et al (1993) Prevalence of urinary tract infection in febrile infants. J Pediatr 123(1):17–23

    Article  PubMed  CAS  Google Scholar 

  • Hoberman A, Wald ER et al (1996) Is urine culture necessary to rule out urinary tract infection in young febrile children? Pediatr Infect Dis J 15(4):304–309

    Article  PubMed  CAS  Google Scholar 

  • Hoberman A, Wald ER et al (1999) Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics 104(1 Pt 1):79–86

    Article  PubMed  CAS  Google Scholar 

  • Hodson EM, Willis NS et al (2007) Antibiotics for acute pyelonephritis in children. Cochrane Database Syst Rev 4, CD003772

    Google Scholar 

  • Hollowell JG, Greenfield SP (2002) Screening siblings for vesicoureteral reflux. J Urol 168(5):2138–2141

    Article  PubMed  Google Scholar 

  • Houle AM, Cheikhelard A et al (2004) Impact of early screening for reflux in siblings on the detection of renal damage. BJU Int 94(1):123–125

    Article  PubMed  Google Scholar 

  • Ismaili K, Avni FE et al (2005) Routine voiding cystourethrography is of no value in neonates with unilateral multicystic dysplastic kidney. J Pediatr 146(6):759–763

    Article  PubMed  Google Scholar 

  • Jacobson SH, Eklof O et al (1989) Development of hypertension and uraemia after pyelonephritis in childhood: 27 year follow up. BMJ 299(6701):703–706

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jakobsson B, Jacobson SH et al (1999) Vesico-ureteric reflux and other risk factors for renal damage: identification of high- and low-risk children. Acta Paediatr Suppl 88(431):31–39

    Article  PubMed  CAS  Google Scholar 

  • Jemni L, Mdimagh L et al (1992) Kidney carbuncle: diagnostic, bacteriological and therapeutic considerations. Apropos of 11 cases. J Urol (Paris) 98(4):228–231

    CAS  Google Scholar 

  • Jodal U, Hansson S (1994) Urinary tract infection. In: Holliday MA, Barratt TM, Avner ED (eds) Pediatric Nephrology. Williams & Wilkins, Baltimore, pp 950–962

    Google Scholar 

  • Jodal U, Lindberg U (1999) Guidelines for management of children with urinary tract infection and vesico-ureteric reflux. Recommendations from a Swedish state-of-the-art conference. Swedish Medical Research Council. Acta Paediatr Suppl 88(431):87–89

    PubMed  CAS  Google Scholar 

  • Jodal U, Smellie JM et al (2006) Ten-year results of randomized treatment of children with severe vesicoureteral reflux. Final report of the International Reflux Study in Children. Pediatr Nephrol 21(6):785–792

    Article  PubMed  Google Scholar 

  • Juliano TM, Stephany HA et al (2013) Incidence of abnormal imaging and recurrent pyelonephritis after first febrile urinary tract infection in children 2 to 24 months old. J Urol 190(4 Suppl):1505–1510

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaneko K, Ohtomo Y et al (2003) Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux. Pediatr Nephrol 18(5):468–470

    PubMed  Google Scholar 

  • Kanellopoulos TA, Salakos C et al (2006) First urinary tract infection in neonates, infants and young children: a comparative study. Pediatr Nephrol 21(8):1131–1137

    Article  PubMed  Google Scholar 

  • Kasanen A, Sundquist H et al (1983) Secondary prevention of urinary tract infections. The role of trimethoprim alone. Ann Clin Res 15(Suppl 36):1–36

    PubMed  CAS  Google Scholar 

  • Kass EH, Finland M (2002) Asymptomatic infections of the urinary tract. J Urol 168(2):420–424

    Article  PubMed  Google Scholar 

  • Keren R, Chan E (2002) A meta-analysis of randomized, controlled trials comparing short- and long-course antibiotic therapy for urinary tract infections in children. Pediatrics 109(5), E70

    Article  PubMed  Google Scholar 

  • Keren R, Carpenter MA et al (2008) Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study. Pediatrics 122(Suppl 5):S240–S250

    Article  PubMed  Google Scholar 

  • Kibar Y, Ors O et al (2007) Results of biofeedback treatment on reflux resolution rates in children with dysfunctional voiding and vesicoureteral reflux. Urology 70(3):563–566; discussion 566–567

    Article  PubMed  Google Scholar 

  • Kiernan SC, Pinckert TL et al (1993) Ultrasound guidance of suprapubic bladder aspiration in neonates. J Pediatr 123(5):789–791

    Article  PubMed  CAS  Google Scholar 

  • Kincaid-Smith PS, Bastos MG et al (1984) Reflux nephropathy in the adult. Contrib Nephrol 39:94–101

    Article  PubMed  CAS  Google Scholar 

  • Klar A, Hurvitz H et al (1996) Focal bacterial nephritis (lobar nephronia) in children. J Pediatr 128(6):850–853

    Article  PubMed  CAS  Google Scholar 

  • Koff SA, Wagner TT et al (1998) The relationship among dysfunctional elimination syndromes, primary vesicoureteral reflux and urinary tract infections in children. J Urol 160(3 Pt 2):1019–1022

    Article  PubMed  CAS  Google Scholar 

  • Kotoula A, Gardikis S et al (2009) Comparative efficacies of procalcitonin and conventional inflammatory markers for prediction of renal parenchymal inflammation in pediatric first urinary tract infection. Urology 73(4):782–786

    Article  PubMed  Google Scholar 

  • Lama G, Tedesco MA et al (2003) Reflux nephropathy and hypertension: correlation with the progression of renal damage. Pediatr Nephrol 18(3):241–245

    PubMed  Google Scholar 

  • Lebowitz RL, Blickman JG (1983) The coexistence of ureteropelvic junction obstruction and reflux. AJR Am J Roentgenol 140(2):231–238

    Article  PubMed  CAS  Google Scholar 

  • Lee JH, Choi HS et al (2008) Nonrefluxing neonatal hydronephrosis and the risk of urinary tract infection. J Urol 179(4):1524–1528

    Article  PubMed  Google Scholar 

  • Lendvay TS, Sorensen M et al (2006) The evolution of vesicoureteral reflux management in the era of dextranomer/hyaluronic acid copolymer: a pediatric health information system database study. J Urol 176(4 Pt 2):1864–1867

    Article  PubMed  CAS  Google Scholar 

  • Leroy S, Romanello C et al (2007) Procalcitonin to reduce the number of unnecessary cystographies in children with a urinary tract infection: a European validation study. J Pediatr 150(1):89–95

    Article  PubMed  CAS  Google Scholar 

  • Leroy S, Romanello C et al (2011) Procalcitonin is a Predictor for High-Grade Vesicoureteral Reflux in Children: Meta-Analysis of Individual Patient Data. J Pediatr 159(4):644–651, e4

    Article  PubMed  CAS  Google Scholar 

  • Lich R Jr, Howerton LW et al (1961) Childhood urosepsis. J Ky Med Assoc 59:1177–1179

    PubMed  Google Scholar 

  • Loening-Baucke V (1997) Urinary incontinence and urinary tract infection and their resolution with treatment of chronic constipation of childhood. Pediatrics 100(2 Pt 1):228–232

    Article  PubMed  CAS  Google Scholar 

  • Lohr JA (1991) Use of routine urinalysis in making a presumptive diagnosis of urinary tract infection in children. Pediatr Infect Dis J 10(9):646–650

    Article  PubMed  CAS  Google Scholar 

  • Lutter SA, Currie ML et al (2005) Antibiotic resistance patterns in children hospitalized for urinary tract infections. Arch Pediatr Adolesc Med 159(10):924–928

    Article  PubMed  Google Scholar 

  • Ma JF, Shortliffe LM (2004) Urinary tract infection in children: etiology and epidemiology. Urol Clin North Am 31(3):517–526, ix–x

    Article  PubMed  Google Scholar 

  • Mackie GG, Stephens FD (1975) Duplex kidneys: a correlation of renal dysplasia with position of the ureteral orifice. J Urol 114(2):274–280

    Article  PubMed  CAS  Google Scholar 

  • Magin EC, Garcia-Garcia JJ et al (2007) Efficacy of short-term intravenous antibiotic in neonates with urinary tract infection. Pediatr Emerg Care 23(2):83–86

    Article  PubMed  Google Scholar 

  • Mahant S, To T et al (2001) Timing of voiding cystourethrogram in the investigation of urinary tract infections in children. J Pediatr 139(4):568–571

    Article  PubMed  CAS  Google Scholar 

  • Malone PS (2005) Circumcision for preventing urinary tract infection in boys: European view. Arch Dis Child 90(8):773–774

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Marchand M, Kuffer F et al (2007) Long-term outcome in women who underwent anti-reflux surgery in childhood. J Pediatr Urol 3(3):178–183

    Article  PubMed  Google Scholar 

  • Marild S, Jodal U (1998) Incidence rate of first-time symptomatic urinary tract infection in children under 6 years of age. Acta Paediatr 87(5):549–552

    Article  PubMed  CAS  Google Scholar 

  • Marild S, Hansson S et al (2004) Protective effect of breastfeeding against urinary tract infection. Acta Paediatr 93(2):164–168

    Article  PubMed  CAS  Google Scholar 

  • McCracken GH Jr (1984) Recurrent urinary tract infections in children. Pediatr Infect Dis 3(3 Suppl):S28–S30

    Article  PubMed  Google Scholar 

  • McDonald A, Scranton M et al (2000) Voiding cystourethrograms and urinary tract infections: how long to wait? Pediatrics 105(4), E50

    Article  PubMed  CAS  Google Scholar 

  • Merrick MV, Notghi A et al (1995) Long-term follow up to determine the prognostic value of imaging after urinary tract infections. Part 2: Scarring. Arch Dis Child 72(5):393–396

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Michael M, Hodson EM et al (2003) Short versus standard duration oral antibiotic therapy for acute urinary tract infection in children. Cochrane Database Syst Rev 1, CD003966

    Google Scholar 

  • Miller TE, Findon G (1985) Genetic factor(s) influence scar formation in experimental pyelonephritis. Nephron 40(3):374–375

    Article  PubMed  CAS  Google Scholar 

  • Miller JL, Krieger JN (2002) Urinary tract infections cranberry juice, underwear, and probiotics in the 21st century. Urol Clin North Am 29(3):695–699

    Article  PubMed  Google Scholar 

  • Miller T, Phillips S (1981) Pyelonephritis: the relationship between infection, renal scarring, and antimicrobial therapy. Kidney Int 19(5):654–662

    Article  PubMed  CAS  Google Scholar 

  • Miron D, Daas A et al (2007) Is omitting post urinary-tract-infection renal ultrasound safe after normal antenatal ultrasound? An observational study. Arch Dis Child 92(6):502–504

    Article  PubMed  PubMed Central  Google Scholar 

  • Montini G, Toffolo A et al (2007) Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial. BMJ 335(7616):386

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Montini G, Rigon L et al (2008) Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial. Pediatrics 122(5):1064–1071

    Article  PubMed  Google Scholar 

  • Montini G, Zucchetta P et al (2009) Value of imaging studies after a first febrile urinary tract infection in young children: data from Italian renal infection study 1. Pediatrics 123(2):e239–e246

    Article  PubMed  Google Scholar 

  • Moorthy I, Easty M et al (2005) The presence of vesicoureteric reflux does not identify a population at risk for renal scarring following a first urinary tract infection. Arch Dis Child 90(7):733–736

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mori R, Lakhanpaul M et al (2007) Diagnosis and management of urinary tract infection in children: summary of NICE guidance. BMJ 335(7616):395–397

    Article  PubMed  PubMed Central  Google Scholar 

  • Murawski IJ, Gupta IR (2006) Vesicoureteric reflux and renal malformations: a developmental problem. Clin Genet 69(2):105–117

    Article  PubMed  CAS  Google Scholar 

  • Murer L, Benetti E et al (2007) Embryology and genetics of primary vesico-ureteric reflux and associated renal dysplasia. Pediatr Nephrol 22(6):788–797

    Article  PubMed  PubMed Central  Google Scholar 

  • Najmaldin A, Burge DM et al (1990) Reflux nephropathy secondary to intrauterine vesicoureteric reflux. J Pediatr Surg 25(4):387–390

    Article  PubMed  CAS  Google Scholar 

  • Nakai H, Asanuma H et al (2003) Changing concepts in urological management of the congenital anomalies of kidney and urinary tract, CAKUT. Pediatr Int 45(5):634–641

    Article  PubMed  Google Scholar 

  • Nakanishi K, Yoshikawa N (2003) Genetic disorders of human congenital anomalies of the kidney and urinary tract (CAKUT). Pediatr Int 45(5):610–616

    Article  PubMed  CAS  Google Scholar 

  • Neuhaus TJ, Berger C et al (2008) Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis. Eur J Pediatr 167(9):1037–1047

    Article  PubMed  CAS  Google Scholar 

  • Neveus T, von Gontard A et al (2006) The standardization of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children’s Continence Society. J Urol 176(1):314–324

    Article  PubMed  Google Scholar 

  • Nicholson L, Smith DP (2007) Dysfunctional elimination syndrome. Where constipation, daytime urinary problems and bedwetting merge. Adv Nurse Pract 15(3):26–31; quiz 31–32

    PubMed  Google Scholar 

  • Noe HN (1996) Screening for reflux--the current status. J Urol 156(5):1808

    Article  PubMed  CAS  Google Scholar 

  • Noe HN (2002) Scintigraphic screening for renal damage in siblings of children with asymptomatic primary vesico-ureteric reflux. BJU Int 89(7):792–793; author reply 793

    Article  PubMed  CAS  Google Scholar 

  • Nuutinen M, Uhari M (2001) Recurrence and follow-up after urinary tract infection under the age of 1 year. Pediatr Nephrol 16(1):69–72

    Article  PubMed  CAS  Google Scholar 

  • O’Regan S, Yazbeck S (1985) Constipation: a cause of enuresis, urinary tract infection and vesico-ureteral reflux in children. Med Hypotheses 17(4):409–413

    Article  PubMed  Google Scholar 

  • O’Regan S, Yazbeck S et al (1985) Constipation, bladder instability, urinary tract infection syndrome. Clin Nephrol 23(3):152–154

    PubMed  Google Scholar 

  • Ozen S, Alikasifoglu M et al (1999) Implications of certain genetic polymorphisms in scarring in vesicoureteric reflux: importance of ACE polymorphism. Am J Kidney Dis 34(1):140–145

    Article  PubMed  CAS  Google Scholar 

  • Pennesi M, Travan L et al (2008) Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. Pediatrics 121(6):e1489–e1494

    Article  PubMed  Google Scholar 

  • Peters CA, Skoog SJ et al (2010) Summary of the AUA Guideline on Management of Primary Vesicoureteral Reflux in Children. J Urol 184(3):1134–1144

    Article  PubMed  Google Scholar 

  • Piercey KR, Khoury AE et al (1993) Diagnosis and management of urinary tract infections. Curr Opin Urol 3:25–29

    Article  Google Scholar 

  • Politano VA, Leadbetter WF (1958) An operative technique for the correction of vesicoureteral reflux. J Urol 79(6):932–941

    Article  PubMed  CAS  Google Scholar 

  • Polito C, Rambaldi PF et al (2001) Unilateral vesicoureteric reflux: Low prevalence of contralateral renal damage. J Pediatr 138(6):875–879

    Article  PubMed  CAS  Google Scholar 

  • Polito C, Rambaldi PF et al (2006) Permanent renal parenchymal defects after febrile UTI are closely associated with vesicoureteric reflux. Pediatr Nephrol 21(4):521–526

    Article  PubMed  Google Scholar 

  • Preda I, Jodal U et al (2007) Normal dimercaptosuccinic acid scintigraphy makes voiding cystourethrography unnecessary after urinary tract infection. J Pediatr 151(6):581–584, 584.e1

    Article  PubMed  Google Scholar 

  • Preda I, Jodal U et al (2010) Value of ultrasound in evaluation of infants with first urinary tract infection. J Urol 183(5):1984–1988

    Article  PubMed  Google Scholar 

  • Preda I, Jodal U et al (2011) Imaging strategy for infants with urinary tract infection: a new algorithm. J Urol 185(3):1046–1052

    Article  PubMed  Google Scholar 

  • Puri P, Pirker M et al (2006) Subureteral dextranomer/hyaluronic acid injection as first line treatment in the management of high grade vesicoureteral reflux. J Urol 176(4 Pt 2):1856–1859; discussion 1859–1860

    Article  PubMed  CAS  Google Scholar 

  • Ransley PG, Risdon RA (1981) Reflux nephropathy: effects of antimicrobial therapy on the evolution of the early pyelonephritic scar. Kidney Int 20(6):733–742

    Article  PubMed  CAS  Google Scholar 

  • Redman JF (1976) Vesicoureteral reflux in identical twins. J Urol 116(6):792–793

    Article  PubMed  CAS  Google Scholar 

  • Riccabona M (2002) Cystography in infants and children: a critical appraisal of the many forms with special regard to voiding cystourethrography. Eur Radiol 12(12):2910–2918

    Article  PubMed  Google Scholar 

  • Riccabona M, Avni FE et al (2008) Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. Pediatr Radiol 38(2):138–145

    Article  PubMed  Google Scholar 

  • Riedmiller H, Becht E et al (1984) Psoas-hitch ureteroneocystostomy: experience with 181 cases. Eur Urol 10(3):145–150

    Article  PubMed  CAS  Google Scholar 

  • RIVUR Trial Investigators (2014) Antimicrobial Prophylaxis for Children with Vesicoureteral Reflux. N Engl J Med 370(25):2367–2376

    Article  CAS  Google Scholar 

  • Roussey-Kesler G, Gadjos V et al (2008) Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: results from a prospective randomized study. J Urol 179(2):674–679; discussion 679

    Article  PubMed  CAS  Google Scholar 

  • Rushton HG (1997) The evaluation of acute pyelonephritis and renal scarring with technetium 99m-dimercaptosuccinic acid renal scintigraphy: evolving concepts and future directions. Pediatr Nephrol 11(1):108–120

    Article  PubMed  CAS  Google Scholar 

  • Rushton HG, Majd M (1992) Pyelonephritis in male infants: how important is the foreskin? J Urol 148(2 Pt 2):733–736; discussion 737–738

    Article  PubMed  CAS  Google Scholar 

  • Saadeh SA, Mattoo TK (2011) Managing urinary tract infections. Pediatr Nephrol 26(11):1967–1976

    Article  PubMed  PubMed Central  Google Scholar 

  • Sargent MA (2000) What is the normal prevalence of vesicoureteral reflux? Pediatr Radiol 30(9):587–593

    Article  PubMed  CAS  Google Scholar 

  • Sastre JB, Aparicio AR et al (2007) Urinary tract infection in the newborn: clinical and radio imaging studies. Pediatr Nephrol 22(10):1735–1741

    Article  PubMed  Google Scholar 

  • Sathapornwajana P, Dissaneewate P et al (2008) Timing of voiding cystourethrogram after urinary tract infection. Arch Dis Child 93(3):229–231

    Article  PubMed  CAS  Google Scholar 

  • Schlager TA, Hendley JO et al (1995) Explanation for false-positive urine cultures obtained by bag technique. Arch Pediatr Adolesc Med 149(2):170–173

    Article  PubMed  CAS  Google Scholar 

  • Shaikh N, Hoberman A et al (2003) Dysfunctional elimination syndrome: is it related to urinary tract infection or vesicoureteral reflux diagnosed early in life? Pediatrics 112(5):1134–1137

    Article  PubMed  Google Scholar 

  • Shaikh N, Morone NE et al (2007) Does this child have a urinary tract infection? JAMA 298(24):2895–2904

    Article  PubMed  CAS  Google Scholar 

  • Shaikh N, Morone NE et al (2008) Prevalence of urinary tract infection in childhood: a meta-analysis. Pediatr Infect Dis J 27(4):302–308

    Article  PubMed  Google Scholar 

  • Shimizu M, Katayama K et al (2005) Evolution of acute focal bacterial nephritis into a renal abscess. Pediatr Nephrol 20(1):93–95

    Article  PubMed  Google Scholar 

  • Shiraishi K, Yoshino K et al (2010) Risk factors for breakthrough infection in children with primary vesicoureteral reflux. J Urol 183(4):1527–1531

    Article  PubMed  Google Scholar 

  • Sillen U (1999) Vesicoureteral reflux in infants. Pediatr Nephrol 13(4):355–361

    Article  PubMed  CAS  Google Scholar 

  • Simoes e Silva AC, Silva JM et al (2007) Risk of hypertension in primary vesicoureteral reflux. Pediatr Nephrol 22(3):459–462

    Article  PubMed  Google Scholar 

  • Singh-Grewal D, Macdessi J et al (2005) Circumcision for the prevention of urinary tract infection in boys: a systematic review of randomised trials and observational studies. Arch Dis Child 90(8):853–858

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Siomou E, Giapros V et al (2009) Implications of 99mTc-DMSA scintigraphy performed during urinary tract infection in neonates. Pediatrics 124(3):881–887

    Article  PubMed  Google Scholar 

  • Slotki IN, Asscher AW (1982) Prevention of scarring in experimental pyelonephritis in the rat by early antibiotic therapy. Nephron 30(3):262–268

    Article  PubMed  CAS  Google Scholar 

  • Smellie JM, Normand IC (1979) Reflux Nephropathy in Childhood. In: Hodson J, Kincaid-Smith P (eds) Reflux Nephropathy. Masson Publishing USA, New York, pp 14–20

    Google Scholar 

  • Smellie JM, Edwards D et al (1975) VUR and renal scarring. Kidney Int 8:65–72

    Article  Google Scholar 

  • Smellie JM, Ransley PG et al (1985) Development of new renal scars: a collaborative study. Br Med J (Clin Res Ed) 290(6486):1957–1960

    Article  CAS  Google Scholar 

  • Smellie JM, Tamminen-Mobius T et al (1992) Five-year study of medical or surgical treatment in children with severe reflux: radiological renal findings. The International Reflux Study in Children. Pediatr Nephrol 6(3):223–230

    Article  PubMed  CAS  Google Scholar 

  • Snodgrass W (1991) Relationship of voiding dysfunction to urinary tract infection and vesicoureteral reflux in children. Urology 38(4):341–344

    Article  PubMed  CAS  Google Scholar 

  • Song SH, Lee SB et al (2007) Is antibiotic prophylaxis necessary in infants with obstructive hydronephrosis? J Urol 177(3):1098–1101; discussion 1101

    Article  PubMed  Google Scholar 

  • Spencer JD, Schwaderer A et al (2010) Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA. Pediatr Nephrol 25(12):2469–2475

    Article  PubMed  PubMed Central  Google Scholar 

  • Steiss JO, Hamscho N et al (2014) Renal carbuncle and perirenal abscess in children and adolescents. Urologe A

    Google Scholar 

  • Swerkersson S, Jodal U et al (2007) Relationship among vesicoureteral reflux, urinary tract infection and renal damage in children. J Urol 178(2):647–651; discussion 650–1

    Article  PubMed  Google Scholar 

  • Tekgul S, Riedmiller H et al (2012) EAU Guidelines on Vesicoureteral Reflux in Children. Eur Urol 62(3):534–542

    Article  PubMed  Google Scholar 

  • Thompson RH, Chen JJ et al (2001) Cessation of prophylactic antibiotics for managing persistent vesicoureteral reflux. J Urol 166(4):1465–1469

    Article  PubMed  CAS  Google Scholar 

  • Thompson M, Simon SD et al (2005) Timing of follow-up voiding cystourethrogram in children with primary vesicoureteral reflux: development and application of a clinical algorithm. Pediatrics 115(2):426–434

    Article  PubMed  Google Scholar 

  • Tokgoz H, Tan MO et al (2007) Assessment of urinary symptoms in children with dysfunctional elimination syndrome. Int Urol Nephrol 39(2):425–436

    Article  PubMed  Google Scholar 

  • Tsai JD, Huang FY et al (1998) Asymptomatic vesicoureteral reflux detected by neonatal ultrasonographic screening. Pediatr Nephrol 12(3):206–209

    Article  PubMed  CAS  Google Scholar 

  • Tullus K (2011) Difficulties in diagnosing urinary tract infections in small children. Pediatr Nephrol 26(11):1923–1926

    Article  PubMed  Google Scholar 

  • Ulman I, Jayanthi VR et al (2000) The long-term followup of newborns with severe unilateral hydronephrosis initially treated nonoperatively. J Urol 164(3 Pt 2):1101–1105

    Article  PubMed  CAS  Google Scholar 

  • Vaillancourt S, McGillivray D et al (2007) To clean or not to clean: effect on contamination rates in midstream urine collections in toilet-trained children. Pediatrics 119(6):e1288–e1293

    Article  PubMed  Google Scholar 

  • Van den Abbeele AD, Treves ST et al (1987) Vesicoureteral reflux in asymptomatic siblings of patients with known reflux: radionuclide cystography. Pediatrics 79(1):147–153

    PubMed  Google Scholar 

  • Vernon SJ, Coulthard MG et al (1997) New renal scarring in children who at age 3 and 4 years had had normal scans with dimercaptosuccinic acid: follow up study. BMJ 315(7113):905–908

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wallace DM, Rothwell DL et al (1978) The long-term follow-up of surgically treated vesicoureteric reflux. Br J Urol 50(7):479–484

    Article  PubMed  CAS  Google Scholar 

  • Walsh TJ, Hsieh S et al (2007) Antenatal hydronephrosis and the risk of pyelonephritis hospitalization during the first year of life. Urology 69(5):970–974

    Article  PubMed  Google Scholar 

  • Wennerstrom M, Hansson S et al (2000) Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr 136(1):30–34

    Article  PubMed  CAS  Google Scholar 

  • Westenfelder M, Beetz R (2010) Diagnostic work-up of urinary tract infections in children. In: Naber K, Schaeffer AJ, Hynes CF (eds) Urogenital infections. European Association of Urology

    Google Scholar 

  • Wettergren B, Fasth A et al (1980) UTI during the first year of life in a Göteborg area 1977–79. Pediatr Res 14:981

    Article  Google Scholar 

  • Williams G, Fletcher JT et al (2008) Vesicoureteral reflux. J Am Soc Nephrol 19(5):847–862

    Article  PubMed  CAS  Google Scholar 

  • Williams GJ, Macaskill P et al (2010) Absolute and relative accuracy of rapid urine tests for urinary tract infection in children: a meta-analysis. Lancet Infect Dis 10(4):240–250

    Article  PubMed  Google Scholar 

  • Winberg J (1990) What antibiotics should be used for prophylaxis against recurrent urinary tract infections in childhood? Pediatr Nephrol 4:244

    Article  Google Scholar 

  • Winberg J (1994) Management of primary vesico-ureteric reflux in children--operation ineffective in preventing progressive renal damage. Infection 22(Suppl 1):S4–S7

    Article  PubMed  Google Scholar 

  • Winberg J, Andersen HJ et al (1974) Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatr Scand Suppl (252):1–20

    Article  Google Scholar 

  • Winberg J, Bergstrom T et al (1975) Morbidity, age and sex distribution, recurrences and renal scarring in symptomatic urinary tract infection in childhood. Kidney Int Suppl 4:S101–S106

    PubMed  CAS  Google Scholar 

  • Wingerter S, Bachur R (2011) Risk factors for contamination of catheterized urine specimens in febrile children. Pediatr Emerg Care 27(1):1–4

    Article  PubMed  Google Scholar 

  • Wiswell TE, Hachey WE (1993) Urinary tract infections and the uncircumcised state: an update. Clin Pediatr (Phila) 32(3):130–134

    Article  CAS  Google Scholar 

  • Wiswell TE, Miller GM et al (1988) Effect of circumcision status on periurethral bacterial flora during the first year of life. J Pediatr 113(3):442–446

    Article  PubMed  CAS  Google Scholar 

  • Yeung CK, Godley ML et al (1997) The characteristics of primary vesico-ureteric reflux in male and female infants with pre-natal hydronephrosis. Br J Urol 80(2):319–327

    Article  PubMed  CAS  Google Scholar 

  • Yeung CK, Sreedhar B et al (2006) Renal and bladder functional status at diagnosis as predictive factors for the outcome of primary vesicoureteral reflux in children. J Urol 176(3):1152–1156; discussion 1156–1157

    Article  PubMed  CAS  Google Scholar 

  • Zorc JJ, Kiddoo DA et al (2005a) Diagnosis and management of pediatric urinary tract infections. Clin Microbiol Rev 18(2):417–422

    Article  PubMed  PubMed Central  Google Scholar 

  • Zorc JJ, Levine DA et al (2005b) Clinical and demographic factors associated with urinary tract infection in young febrile infants. Pediatrics 116(3):644–648

    Article  PubMed  Google Scholar 

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  1. Pediatric Nephrology, Center for Paediatrics and Adolescent Medicine, University Medical Clinic, Langenbeckstr. 1, D – 55131, Mainz, Germany

    Rolf Beetz

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    Michael Riccabona

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Beetz, R. (2018). UTI and VUR. In: Riccabona, M. (eds) Pediatric Urogenital Radiology. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/978-3-319-39202-8_13

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