Abstract
As a consequence of a global increase in rates of extremely preterm birth, predicting the long term impact of preterm birth has become an important focus of research. Cohorts of extremely preterm born subjects studied in the 1990s are now beginning to reach adulthood and the long term structural alterations of disrupted neurodevelopment in gestation can now be investigated, for instance with magnetic resonance (MR) imaging. Disruption to normal development as a result of preterm birth is likely to result in both cerebrovascular and microstructural differences compared to term-born controls. Of note, arterial spin labelled MRI provides a marker of cerebral blood flow, whilst multi-compartment diffusion models provide information on the cerebral microstructure, including that of the cortex. We apply these techniques to a cohort of 19 year-old adolescents consisting of both extremely-preterm and term-born individuals and investigate the structural and functional correlations of these MR modalities. Work of this type, revealing the long-term structural and functional differences in preterm cohorts, can help better inform on the likely outcomes of contemporary extremely preterm newborns and provides an insight into the lifelong effects of preterm birth.
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Costeloe, K.L., Hennessy, E.M., Haider, S., Stacey, F., Marlow, N., Draper, E.S.: Short term outcomes after extreme preterm birth in england: comparison of two birth cohorts in, and (the epicure studies). BMJ 345, e7976 (1995)
Lewandowski, A.J., Augustine, D., Lamata, P., Davis, E.F., Lazdam, M., Francis, J., McCormick, K., Wilkinson, A.R., Singhal, A., Lucas, A., Smith, N.P., Neubauer, S., Leeson, P.: Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function. Circulation 127(2), 197–206 (2013)
Alsop, D.C., Detre, J.A., Golay, X., Günther, M., Hendrikse, J., Lu, H., Macintosh, B.J., Parkes, L.M., Smits, M., van Osch, M.J.P., Wang, D.J.J., Wong, E.C., Zaharchuk, G.: Recommended implementation of arterial spin-labeled perfusion mri for clinical applications: A consensus of the ismrm perfusion study group and the european consortium for asl in dementia. Magn. Reson. Med. (April 2014)
Eaton-Rosen, Z., Melbourne, A., Orasanu, E., Cardoso, M.J., Modat, M., Bainbridge, A., Kendall, G.S., Robertson, N.J., Marlow, N., Ourselin, S.: Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal mri. Neuroimage 111, 580–589 (2015)
Volpe, J.J.: Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol. 8(1), 110–124 (2009)
Buxton, R.B., Frank, L.R.: A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J. Cereb. Blood Flow Metab. 17(1), 64–72 (1997)
Hoge, R.D., Atkinson, J., Gill, B., Crelier, G.R., Marrett, S., Pike, G.B.: Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc. Natl. Acad. Sci. U S A 96(16), 9403–9408 (1999)
Cardoso, M.J., Modat, M., Wolz, R., Melbourne, A., Cash, D., Rueckert, D., Ourselin, S.: Geodesic information flows: spatially-variant graphs and their application to segmentation and fusion. IEEE TMI 99 (2015)
Zhang, H., Schneider, T., Wheeler-Kingshott, C.A., Alexander, D.C.: Noddi: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage 61(4), 1000–1016 (2012)
Alexander, D.C., Hubbard, P.L., Hall, M.G., Moore, E.A., Ptito, M., Parker, G.J.M., Dyrby, T.B.: Orientationally invariant indices of axon diameter and density from diffusion mri. Neuroimage 52(4), 1374–1389 (2010)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this paper
Cite this paper
Melbourne, A. et al. (2015). Measuring Cortical Neurite-Dispersion and Perfusion in Preterm-Born Adolescents Using Multi-modal MRI. In: Navab, N., Hornegger, J., Wells, W., Frangi, A. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015. MICCAI 2015. Lecture Notes in Computer Science(), vol 9351. Springer, Cham. https://doi.org/10.1007/978-3-319-24574-4_9
Download citation
DOI: https://doi.org/10.1007/978-3-319-24574-4_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-24573-7
Online ISBN: 978-3-319-24574-4
eBook Packages: Computer ScienceComputer Science (R0)