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Globus Pallidus Interna Deep Brain Stimulation: Practical Guide to Placement with Microelectrode Recording

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Surgery for Parkinson's Disease

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Abstract

Chronic high-frequency deep brain stimulation (DBS) is a Food and Drug Administration (FDA) approved treatment for Parkinson’s disease and has been shown to be more efficacious at improving motor symptoms than medical treatment alone. This chapter will detail the effective targeting of globus pallidus interna (GPi) using a Leksell frame-based approach that relies both on anatomical guidance with magnetic resonance imaging (MRI) and physiological mapping with microelectrode recordings and stimulation. This multimodal approach to stereotactic localization can help overcome the challenges associated with safely and effectively targeting the GPi for DBS.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA

    Eric Hudgins, A. G. Ramayya & G. H. Baltuch

Authors
  1. Eric Hudgins
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  2. A. G. Ramayya
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  3. G. H. Baltuch
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Corresponding author

Correspondence to G. H. Baltuch .

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Editors and Affiliations

  1. Hackensack Meridian School of Medicine at Seton Hall University, Nutley, NJ, USA

    Robert R. Goodman

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Hudgins, E., Ramayya, A.G., Baltuch, G.H. (2019). Globus Pallidus Interna Deep Brain Stimulation: Practical Guide to Placement with Microelectrode Recording. In: Goodman, R. (eds) Surgery for Parkinson's Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-23693-3_4

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  • DOI: https://doi.org/10.1007/978-3-319-23693-3_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23692-6

  • Online ISBN: 978-3-319-23693-3

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