Abstract
Background: Inter-frame image registration is a major hurdle in accurate quantification of myocardial perfusion using MRI. The registration is not standard, in that changing contrast between frames makes it difficult to register the images automatically.
Methods: A multiple step approach was employed. First, a region around the heart was identified out automatically in order to focus the registration. Then we performed rigid shifts between frames with a cross correlation type of method, to obtain a coarse registration. Then we created model images from a two compartment model and an arterial input function from the RV blood pool of the images. These model images represent the uptake and washout of the contrast agent. However they do not contain any motion since the two compartment motion cannot explicitly model motion. These motion-free model images are used as reference images and each frame was registered to its associated model image. Rigid and deformable registration as implemented by ANTS. The entire process was automatic and required ~240 seconds.
This registration approach was tested on the 10 provided ECG-gated rest/stress datasets.
Conclusion: Rigid and deformable registration was performed on the provided datasets. The technique was found to perform better on datasets with higher signal to noise ratio and without sudden respiratory motions.
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References
Bidaut, L.M., Vallee, J.P.: Automated registration of dynamic MR images for the quantification of myocardial perfusion. J. Magn. Reson. Imaging 13, 648–655 (2001)
Gallippi, C.M., Kramer, C.M., Hu, Y.L., Vido, D.A., Reichek, N., Rogers, W.J.: Fully automated registration and warping of contrast-enhanced first pass perfusion images. J. Cardiovasc. Magn. Reson. 4, 459–469 (2002)
Adluru, G., DiBella, E.V., Schabel, M.C.: Model-based registration for dynamic cardiac perfusion MRI. J. Magn. Reson. Imaging 24(5), 1062–1070 (2006)
Harrison, A., et al.: Rapid ungated myocardial perfusion cardiovascular magnetic resonance: preliminary diagnostic accuracy. J. Cardiovasc. Magn. Reson. 15(1), 26 (2013)
Tofts, P.S.: Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J. Magn. Reson. Imaging 7(1), 91–101 (1997)
Avants, B.B., et al.: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med. Image Anal. 12(1), 26–41 (2008)
Avants, B.B., et al.: Advanced Normalization Tools (ANTS), September 2011
Pack, N.A., Vijayakumar, S., Kim, T.H., McGann, C.J., DiBella, E.V.R.: A semi-automatic software package for analysis of dynamic contrast-enhanced MRI myocardial perfusion studies. Computers in Cardiology; S62-6, Park City, UT
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© 2015 Springer International Publishing Switzerland
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Likhite, D., Adluru, G., DiBella, E. (2015). Deformable and Rigid Model-Based Image Registration for Quantitative Cardiac Perfusion. In: Camara, O., Mansi, T., Pop, M., Rhode, K., Sermesant, M., Young, A. (eds) Statistical Atlases and Computational Models of the Heart - Imaging and Modelling Challenges. STACOM 2014. Lecture Notes in Computer Science(), vol 8896. Springer, Cham. https://doi.org/10.1007/978-3-319-14678-2_5
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DOI: https://doi.org/10.1007/978-3-319-14678-2_5
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