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THiMED: Time in Hierarchical Model Extraction and Design

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Computational Methods in Systems Biology (CMSB 2014)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 8859))

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Abstract

We describe our approach to modeling timing of cell signaling systems in which existing information about the system spans from detailed mechanistic knowledge to much coarser observations about cause and effect. The results for several models emphasize the fact that the selection of timing implementation can have both qualitative and quantitative effects on the model’s transient behavior and its steady state.

This work is supported in part by DARPA award W911NF-14-1-0422.

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References

  1. Miskov-Zivanov, N., et al.: The duration of T cell stimulation is a critical determinant of cell fate and plasticity. In Science Signaling 6, ra97 (2013)

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Author information

Authors and Affiliations

  1. Electrical and Computer Engineering Department, Carnegie Mellon University, USA

    Natasa Miskov-Zivanov, Peter Wei & Chang Sheng Clement Loh

  2. Computer Science Department, Carnegie Mellon University, Pittsburgh, USA

    Natasa Miskov-Zivanov

Authors
  1. Natasa Miskov-Zivanov
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  2. Peter Wei
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  3. Chang Sheng Clement Loh
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Editor information

Editors and Affiliations

  1. Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, M1 7DN, Manchester, UK

    Pedro Mendes , Joseph O. Dada  & Kieran Smallbone ,  & 

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© 2014 Springer International Publishing Switzerland

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Miskov-Zivanov, N., Wei, P., Loh, C.S.C. (2014). THiMED: Time in Hierarchical Model Extraction and Design. In: Mendes, P., Dada, J.O., Smallbone, K. (eds) Computational Methods in Systems Biology. CMSB 2014. Lecture Notes in Computer Science(), vol 8859. Springer, Cham. https://doi.org/10.1007/978-3-319-12982-2_22

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  • DOI: https://doi.org/10.1007/978-3-319-12982-2_22

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12981-5

  • Online ISBN: 978-3-319-12982-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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