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Complex Diffusion in Bacteria

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Physical Microbiology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1267))

Abstract

Diffusion within bacteria is often thought of as a “simple” random process by which molecules collide and interact with each other. New research however shows that this is far from the truth. Here we shed light on the complexity and importance of diffusion in bacteria, illustrating the similarities and differences of diffusive behaviors of molecules within different compartments of bacterial cells. We first describe common methodologies used to probe diffusion and the associated models and analyses. We then discuss distinct diffusive behaviors of molecules within different bacterial cellular compartments, highlighting the influence of metabolism, size, crowding, charge, binding, and more. We also explicitly discuss where further research and a united understanding of what dictates diffusive behaviors across the different compartments of the cell are required, pointing out new research avenues to pursue.

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Acknowledgements

We would like to thank Dr. Xinxing Yang and Nicolas Yehya for their comments and feedback.

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Authors and Affiliations

  1. Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Christopher H. Bohrer & Jie Xiao

  2. Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA

    Christopher H. Bohrer

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  1. Christopher H. Bohrer
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  2. Jie Xiao
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Editors and Affiliations

  1. Pathogenesis of Vascular Infections, Institut Pasteur, Paris, France

    Guillaume Duménil

  2. Microbial Morphogenesis and Growth, Institut Pasteur, Paris, France

    Sven van Teeffelen

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Bohrer, C.H., Xiao, J. (2020). Complex Diffusion in Bacteria. In: Duménil, G., van Teeffelen, S. (eds) Physical Microbiology. Advances in Experimental Medicine and Biology, vol 1267. Springer, Cham. https://doi.org/10.1007/978-3-030-46886-6_2

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