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The Nitrile Imine 1,3-Dipole pp 99–150Cite as

Applications of Nitrile Imine Derivatives

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Abstract

Nitrile imines have been employed in a diverse range of fields relating to the chemical sciences. This likely originates from the pleiotropic reactivity of the dipole, coupled with the diverse range of methods available for their generation. The overwhelming majority of these applications utilise the facile and often orthogonal 1,3-dipolar cycloaddition between nitrile imines and electronically- or strain-activated alkenes. More recent reports have also explored the introduction of hydrazide synthesis through the combination of the dipole with carboxylic acids. In addition to the adaption of nitrile imines within traditional chemical synthesis, the dipole has also demonstrated widespread application in both bioorthogonal chemistry and materials science as a ligation agent.

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Authors and Affiliations

  1. Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK

    Craig Jamieson

  2. Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK

    Keith Livingstone

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Jamieson, C., Livingstone, K. (2020). Applications of Nitrile Imine Derivatives. In: The Nitrile Imine 1,3-Dipole. Springer, Cham. https://doi.org/10.1007/978-3-030-43481-6_4

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