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Deep Brain Stimulation for Depression

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Fundamentals and Clinics of Deep Brain Stimulation

Abstract

Open-label studies of deep brain stimulation (DBS) for patients with treatment-resistant depression (TRD) are promising: approximately 40% of patients lose at least half of their symptoms following DBS of the subcallosal cingulate cortex (SCC) or ventral capsule and ventral striatum (VC/VS). The results of sham-controlled trials, however, have been mixed so far and show much room for optimization. For instance, targeting specific white matter bundles shows a lot of potential, with at least 70% of patients responding to targeting of patient-specific SCC bundles or the medial forebrain bundle. Exploring the additional value of rehabilitation and cognitive behavioral programs, as well as optimizing parameter selection, could further optimize the treatment.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Isidoor O. Bergfeld

  2. Amsterdam Brain and Cognition, Amsterdam, The Netherlands

    Isidoor O. Bergfeld

  3. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Martijn Figee

Authors
  1. Isidoor O. Bergfeld
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  2. Martijn Figee
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Correspondence to Martijn Figee .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands

    Yasin Temel

  2. Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands

    Albert F.G. Leentjens

  3. Department of Neurology, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, Noord-Holland, The Netherlands

    Rob M.A. de Bie

  4. Department of Neurosurgery, Grenoble University Hospital Center, Grenoble, France

    Stephan Chabardes

  5. Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada

    Alfonso Fasano

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Bergfeld, I.O., Figee, M. (2020). Deep Brain Stimulation for Depression. In: Temel, Y., Leentjens, A., de Bie, R., Chabardes, S., Fasano, A. (eds) Fundamentals and Clinics of Deep Brain Stimulation. Springer, Cham. https://doi.org/10.1007/978-3-030-36346-8_18

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  • DOI: https://doi.org/10.1007/978-3-030-36346-8_18

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