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Racing for the Surface pp 171–188Cite as

Device-Related Infections

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Abstract

Device-related infection is responsible for a quarter of all health care-associated infections and can even compromise device function. These infections are caused by the colonization of microorganisms during the implantation processes. Unfortunately, the treatment option for device-related infection is limited. To make the situation worse, some of these organisms form biofilms that cover the device surface notably weakening the effectiveness of antimicrobial treatments. This chapter summarizes our current understanding of the pathogenesis of device-related infection. It also discusses our knowledge of the processes governing the formation, regulation, and resistance of biofilms. Finally, we introduce several new methods developed for diagnosing and treating biofilm infections on medical devices.

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Authors and Affiliations

  1. Department of Biology, University of Texas at Arlington, Arlington, TX, USA

    Paul Renick

  2. Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA

    Liping Tang

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  2. Liping Tang
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  1. Department of Orthopaedics, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. Microbiology Lab, AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Engineering and Medicine, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Renick, P., Tang, L. (2020). Device-Related Infections. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34475-7_7

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