Abstract
In this chapter, other areas of application for optical clearing agents (OCAs) are presented. The osmotic properties of agents are highly important in dermatology, cosmetics, and pharmacology, if topical application to the skin is desired. After addressing this application in Sect. 8.2, tissue poisoning and discussing the osmotic properties of certain poisons or toxic compounds will be done in Sect. 8.3. The importance of evaluating the diffusion properties of those substances in the skin, eye, and other inner tissue is indicated as a tool for optimizing treatment or decontamination dosage and procedures. Section 8.4 is used to discuss the application of agents in food industry. The dehydration capabilities of certain agents, such as sodium chloride or glycerol, are presented, and the advantages of treating fruit, meat, or fish with sugars to improve their organoleptic properties during preservation are also presented. Finally, the application of OCAs for tissue or organ preservation is presented in Sect. 8.5, where some cases for preservation of eye tissues at room temperature made with glycerol will be discussed. The use of OCAs as cryoprotectants at low temperatures is also explained. In all these applications, we refer the applicability of the method described in Sect. 6.4 to evaluate the diffusion properties of water, poisons, or drugs for ex vivo tissue samples.
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References
D.G. Cogan, Clearing of edematous corneas by glycerin. Am. J. Ophthalmol. 26(5), 551 (1943)
K.C. Swan, A dehydrating jelly to clear corneal bedewing. AMA Arch. Ophthalmol. 50(1), 75–77 (1953)
B. Duvall, R. Kershner, Ophthalmic Medications and Pharmacology, 2nd edn. (SLACK Inc., Thorofare, NJ, 2006), p. 42. Chapter 5
C. Costagliola, V. Romano, E. Forbice, M. Angi, A. Pascotto, T. Boccia, F. Semeraro, Corneal oedema and its medical treatment. Clin. Exp. Optom. 96, 529–535 (2013)
D.M. Maurice, Clearing media for the eye. Br. J. Ophthalmol. 71, 470–472 (1987)
V.V. Tuchin, Optical Clearing of Tissues and Blood (SPIE Press, Bellingham, WA, 2006)
H. Schaefer, T.E. Redelmeier, Skin Barrier: Principles of Percutaneous Absorption (Karger, Basel, 1996)
F. Pirot, Y.N. Kalia, A.L. Stinchcomb, G. Keating, A. Bunge, R.H. Guy, Characterization of the permeable barrier of human skin in vivo. Proc. Natl. Acad. Sci. 94, 1562–1567 (1997)
I.H. Blank, J. Moloney, A.G. Emslie, I. Simon, C. Apt, The diffusion of water across the stratum corneum as a function of its water content. J. Invest. Dermatol. 82, 188–194 (1984)
T. von Zglinicki, M. Lindberg, G.H. Roomans, B. Forslind, Water and ion distribution profiles in human skin. Acta Derm. Venerol. 73, 340–343 (1993)
J.M. Bradner, Importance of tight junctions in relation to skin barrier function. Curr. Probl. Dermatol. 49, 27–37 (2016)
N. Rutter, Drug absorption through the skin: a mixed blessing. Arch. Dis. Child. 62, 220–221 (1987)
S. Mitragotri, Y.G. Anissimov, A.L. Bunge, H.F. Frasch, R.H. Guy, J. Hadgraft, G.B. Kasting, M.E. Lane, M.S. Roberts, Mathematical models of skin permeability: an overview. Int. J. Pharm. 418, 115–129 (2011)
T. Higuchi, Rate of release of medications from ointment bases containing drugs in suspension. J. Pharm. Sci. 50, 874–875 (1961)
P. Schlupp, T. Blaschke, K.D. Kramer, H.-D. Höltje, W. Mehnert, M. Schäfer-Korting, Drug release and skin penetration from solid lipid nanoparticles and a base cream: a systematic approach from a comparison of three glucocorticoids. Skin Pharmacol. Physiol. 24, 199–209 (2011)
H.A.E. Benson, Transdermal drug delivery: penetration enhancement techniques. Curr. Drug Deliv. 2, 23–33 (2005)
J. Hadgraft, J.W. Hadgraft, I. Sarkany, The effect of glycerol on the percutaneous absorption of methyl nicotinate. Br. J. Dermatol. 87(1), 30–36 (1972)
N. Carreras, C. Alonso, M. Martí, M. Lis, Mass transport model through the skin by microencapsulation system. J. Microencapsul. 32(4), 358–363 (2015)
A. Davidson, B. Al-Qallaf, D.B. Das, Transdermal drug delivery by coated microneedles: geometry effects on effective skin thickness and drug permeability. Chem. Eng. Res. Design 86(11), 1196–1206 (2008)
L. Bartosova, J. Bajgar, Transdermal drug delivery in vitro using diffusion cells. Curr. Med. Chem. 19, 4671–4677 (2012)
H. Rothe, C. Obringer, J. Manwaring, C. Avci, W. Wargniez, J. Eilstein, N. Hewitt, R. Cubberley, H. Duplan, D. Lange, C. Jacques-Jamin, M. Klaric, A. Schepky, S. Grégoire, Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum. J. Appl. Toxicol. 37, 806–816 (2017)
E.A. Genina, A.N. Bashkatov, A.A. Korobko, E.A. Zubkova, V.V. Tuchin, I. Yaroslavsky, G.B. Altshuler, Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin. J. Biomed. Opt. 13(2), 021102 (2008)
R. Pjanović, R. Stojanović, M. Šajber, J. Veljković, N. Bošković-Vragolović, S. Pejanović, Diffusion of lidocaine hydrochloride from lipid microparticles. Chem. Ind. Chem. Eng. Quart. 15(1), 33–35 (2009)
A.Y. Sdobnov, M.E. Darvin, J. Schleusener, J. Lademann, V.V. Tuchin, Hydrogen bound water profiles in the skin influenced by optical clearing molecular agents- quantitative analysis using confocal Raman microscopy. J. Biophotonics 12, e201800283 (2019)
K. Dennerlein, F. Kiesewetter, S. Kilo, T. Jäger, T. Göen, G. Korinth, H. Drexler, Dermal absorption and skin damage following hydrofluoric acid. Toxicol. Lett. 248, 25–33 (2016)
L. Thors, S. Lindberg, S. Johansson, M. Koch, L. Hägglund, A. Bucht, RSDL decontamination of human skin contaminated with the nerve agent VX. Toxicol. Lett. 269, 47–54 (2017)
L. Thors, M. Koch, E. Wingenstam, B. Koch, L. Hägglund, A. Bucht, Comparison of skin decontamination efficacy of commercial decontamination products following exposure to VX on human skin. Chem. Biol. Interact. 272, 82–89 (2017)
Y. Cao, X. Hui, H. Zhu, A. Elmahdy, H. Maibach, In vitro human skin permeation and decontamination of 2-chloroethyl ethyl sulfide (CEES) using dermal decontamination gel (DDGEL) and reactive skin decontamination lotion (RSDL). Toxicol. Lett. 291, 86–91 (2018)
S. Gaskin, L. thredgold, L. Heath, D. Pisaniello, M. Logan, C. Baxter, Empirical data in support of a skin notation for methyl chloride. J. Occup. Environ. Hyg. 15(8), 569–572 (2018)
R. van Doorn, P.J.A. Borm, C.M. Leijdekkers, P.T. Henderson, J. Reuvers, T.J. van Bergen, Detection and identification of S-methylcysteine in urine of workers exposed to methyl chloride. Int. Arch. Occup. Environ. Health 46(2), 99–109 (1980)
Agency for Toxic Substances and Disease Registry (ATSDR), Toxicological Profile for Chloromethane (U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA, 1998)
D.R. Mattie, G.D. Bates Jr., G.W. Jepson, J.W. Fisher, J.N. McDougal, Determination of skin:air partition coefficients for volatile chemicals: experimental method and applications. Fundam. Appl. Toxicol. 22, 51–57 (1994)
G. Maina, C. Gastagnoli, G. Ghione, V. Passini, G. Adami, F.L. Filon, M. Grosera, Skin contamination as pathway for nicotine intoxication in vapers. Toxicol. In Vitro 41, 102–105 (2017)
S. Gaskin, L. Heath, D. Pisaniello, R. Evans, J.W. Edwards, M. Logan, C. Baxter, Hydrogen sulphide and phosphine interactions with human skin in vitro: application to hazardous material incident decision making for skin decontamination. Toxicol. Ind. Health 33(4), 289–296 (2017)
T.Y.K. Chan, Aconite poisoning following the percutaneous absorption of Aconitum alkaloids. Forensic Sci. Int. 223, 25–27 (2012)
K.S. Park, J.H. Kwon, S.H. Park, W. Ha, J. Lee, H.C. An, Y. Kim, Acute copper sulfate poisoning resulting from dermal absorption. Am. J. Ind. Med. 61, 783–788 (2018)
S.-K. Han, S.-R. Yeom, S.H. Lee, S.-C. Park, H.-B. Kim, Y.-M. Cho, S.W. Park, A fatal case of chlorfenapyr poisoning following dermal exposure. Hong Kong J. Emerg. Med., 1–4 (2018)
X. Guo, Z. Guo, H. Wei, H. Yang, Y. He, S. Xie, G. Wu, X. Deng, Q. Zhao, L. Li, In vivo comparison of the optical clearing efficacy of optical clearing agents in human skin by quantifying permeability using optical coherence tomography. Photochem. Photobiol. 87(3), 734–740 (2011)
Z. Zhi, Z. Han, Q. Luo, D. Zhu, Improve optical clearing of skin in vitro with propylene glycol as a penetration enhancer. J. Innov. Opt. Health Sci. 2(3), 269–278 (2009)
T.Y. Lim, R.L. Poole, N.M. Pageler, Propylene glycol toxicity in children. J. Pediatr. Pharmacol. Ther. 19(4), 277–282 (2014)
V.D. Genin, A.N. Bashkatov, E.A. Genina, V.V. Tuchin, Measurement of diffusion coefficient of propylene glycol in skin tissue. Proc. SPIE 9448, 94480E (2015)
A.A. Selifonov, V.V. Tuchin, Kinetics of optical properties on selected laser lines of human periodontal gingiva when exposed to glycerol-propylene glycol mixture, in International Symposium FLAMN-19 (Fundamentals of Laser Assisted Micro- & Nanotechnologies), Symposium Program, Paper PS3-C02-9, St. Petersburg, 30 June–4 July, 2019, p.71. https://flamn.ifmo.ru/docs/Program_Symposium_FLAMN_-_19.pdf
S.D. Sheffer, H.L.R. Cooper, N. Pologruto, Delivery of pharmaceutical active ingredients through the skin and hair follicles into dermis and transdermal delivery, US Patent No. US2016/0361264 A1, 15 Dec 2016
E.A. Genina, Y.I. Svenskaya, I.Y. Yanina, L.E. Dolotov, N.A. Navolokin, A.N. Bashkatov, G.S. Terentyuk, A.B. Bucharskaya, G.N. Maslyakova, D.A. Gorin, V.V. Tuchin, G.B. Sukhorukov, In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. Biomed. Opt. Express 7(6), 2082–2087 (2016)
I.Y. Yanina, N.A. Navolokin, Y.I. Svenskaya, A.B. Bucharskaya, G.N. Maslyakova, D.A. Gorin, G.B. Sukhorukov, V.V. Tuchin, Morphology alterations of skin and subcutaneous fat at NIR laser irradiation combined with delivery of encapsulated indocyanine green. J. Biomed. Opt. 22(5), 055008 (2017)
Y.I. Svenskaya, E.A. Genina, B.V. Parakhonskiy, E.V. Lengert, E.E. Talnikova, G.S. Terentyuk, S.R. Utz, D.A. Gorin, V.V. Tuchin, G.B. Sukhorukov, A simple non-invasive approach toward efficient transdermal drug delivery based on biodegradable particulate system. ACS Appl. Mater. Interfaces 11(19), 17270–17282 (2019)
S.R. White, Toxic alcohols, in Rosen’s Emergency Medicine: Concepts and Clinical Practice, ed. by J. A. Marx, R. S. Hockberger, R. M. Walls, vol. 2, 7th edn., (Elsevier, Philadelphia, PA, 2010), pp. 2001–2009
L.M. Oliveira, M.I. Carvalho, E.N. Nogueira, V.V. Tuchin, Diffusion characteristics of ethylene glycol in skeletal muscle. J. Biomed. Opt. 20(5), 051019 (2015)
S. Seidl, B. Schwarze, P. Betz, Lethal cyanide inhalation with post-mortem trans-cutaneous cyanide diffusion. Leg. Med. 5, 238–241 (2003)
P. Rayar, S. Ratnaplan, Pediatric ingestions of house hold products containing ethanol: a review. Clin. Pediatr. 52(3), 203–209 (2012)
https://articles.mercola.com/sites/articles/archive/2015/09/09/toxic-toothpaste-ingredients.aspx. Accessed 22 Mar 2019
S.S. Konstantinović, B.R. Danilović, J.T. Ćirić, S.B. Ilić, D.S. Savić, V.B. Veljković, Valorization of crude glycerol from biodiesel production. Chem. Ind. Chem. Eng. Q. 22(4), 461–489 (2016)
V.K. Garlapati, U. Shankar, A. Budhiraja, Bioconversion technologies of crude glycerol to value added industrial products. Biotech. Rep. 9, 9–14 (2016)
F. Hernández, M. Ibáñez, J.V. Sancho, Fast determination of toxic diethylene glycol in toothpaste by ultra-performance liquid chromatography – time of flight mass spectrometry. Anal. Bioanal. Chem. 391, 1021–1027 (2008)
S. Barry, J.-C. Wolff, Investigation into the quantitative analysis of diethylene glycol in toothpaste by direct analysis in real time mass spectrometry. Rapid Commun. Mass Spectrom. 30, 1829–1834 (2016)
M. Özgöz, H. Yaǧiz, Y. Çiçek, A. Tezel, Gingival necrosis following the use of a paraformaldehyde-containing paste: a case report. Int. Endod. J. 37, 157–161 (2004)
G.N. Teke, N.G. Enongene, A.R. Tiagha, In vitro antimicrobial activity of some commercial toothpastes. Int. J. Curr. Microb. Appl. Sci. 6(1), 433–446 (2017)
B.V. Vannet, B. De Wever, E. Adriaens, F. Ramaeckers, P. Bottenberg, The evaluation of sodium lauryl sulphate in toothpaste on toxicity on human gingiva and mucosa: a 3D in vitro model. Dentistry 5(9), 325-1–325-5 (2015)
B. Cvikl, A. Lussi, R. Gruber, The in vitro impact of toothpaste extracts on cell viability. Eur. J. Oral Sci. 123, 179–185 (2015)
M. Ersoy, J. Tanalp, E. Ozel, R. Cengizlier, M. Soyman, The allergy of toothpaste: a case report. Allergol. Immunopathol. 36(6), 368–370 (2008)
T.H. Figueiredo, J.P. Apland, M.F.M. Braga, A.M. Marini, Acute and long-term consequences of exposure to organophosphate nerve agents in humans. Epilepsia 59(S2), 92–99 (2018)
L. Schenk, K. Feychting, A. Annas, M. Öberg, Records from the Swedish poisons centre as a means for surveillance of occupational accidents and incidents with chemicals. Safety Sci. 104, 269–275 (2018)
P.D. Creswell, J.G. Meiman, H. Nehls-Lowe, C. Vogt, R.J. Wozniak, M.A. Werner, H. Anderson, Exposure to elevated carbon monoxide levels at an indoor ice arena – Wisconsin, 2014. Morb. Mortal. Wkly. Rep. 64(45), 1267–1270 (2015)
T. Kojima, M. Dogru, A. Higuchi, T. Nagata, O.M.A. Ibrahim, T. Inaba, K. Tsubota, Protection from acute tobacco smoke exposure evidence from Nrf2 knockout mice. Am. J. Pathol. 185(3), 776–785 (2015)
N.J. Kleiman, A.M. Quinn, K.G. Fields, V. Slavkovich, J.H. Graziano, Arsenite accumulation in the mouse eye. J. Toxicol. Environ. Health A 79(8), 339–341 (2016)
C. Ratti, Hot air and freeze-drying of high-value foods: a review. J. Food Eng. 49, 311–319 (2001)
M.R. Khan, Osmotic dehydration technique for fruits preservation – a review. Pak. J. Food Sci. 22(2), 71–85 (2012)
R.S.F. Filho, R.P. Gusmão, W.P. Silva, J.P. Gomes, E.V.C. Filho, A.A. El-Aouar, Osmotic dehydration of pineapple stems in hypertonic sucrose solutions. Agric. Sci. 6, 916–924 (2015)
A. Ciurzyńska, H. Kowalska, K. Czajkowska, A. Lenart, Osmotic dehydration in production of sustainable and healthy food. Tends Food Sci. Tech. 50, 186–192 (2016)
I. Ahmed, I.M. Qazi, S. Jamal, Developments in osmotic dehydration technique for the preservation of fruits and vegetables. Innov. Food Sci. Emerg. Technol. 34, 29–43 (2016)
M.S. Rahman, Osmotic dehydration of foods. Chapter 19, in Handbook of Food Preservation, ed. by M. S. Rahman, 2nd edn., (Taylor & Francis Group LLC, CRC Press, Boca Raton, FL, 2007), pp. 433–446
G. Bidaisee, N. Badrie, Osmotic dehydration of cashew apples (Anacardium occidentale L.): quality evaluation of candied cashew apples. Int. J. Food Sci. Technol. 36, 71–78 (2001)
M.H. Kim, R.T. Toledo, Effect of osmotic dehydration and high temperature fluidized bed drying on properties of dehydrated rabbit eye blueberries. J. Food Sci. 52(4), 980–989 (1987)
D. Torreggiani, Technical aspects of osmotic dehydration in foods, in Food Preservation by Moisture Control. Fundamentals and Applications, ed. by G. V. Barbosa-Canovas, J. Welti-Chanes, (Technomic Publishing, Lancaster, PA, 1995), pp. 281–304
F.K. Ertekin, T. Cakaloz, Osmotic dehydration of peas II. Influence of osmosis on drying behavior and product quality. J. Food Process. Preserv. 20, 105–119 (1996)
U. Erle, H. Schubert, Combined osmotic and microwave-vacuum dehydration of apples and strawberries. J. Food Eng. 49, 193–199 (2001)
A. Chiralt, P. Fito, J.M. Barat, A. Andrés, C. González-Martínez, I. Escriche, M.M. Camacho, Use of vacuum impregnation in food salting process. J. Food Eng. 49, 141–151 (2001)
S.M. Monnerat, T.R.M. Pizzi, M.A. Mauro, F.C. Menegalli, Osmotic dehydration of apples in sugar/salt solutions: concentration profiles and effective diffusion coefficients. J. Food Eng. 100, 604–612 (2010)
H.G. Ramya, S. Kumar, S. Kapoor, Optimization of osmotic dehydration process for oyster mushrooms (Pleurotus sajor-caju) in sodium chloride solution using RSM. J. Appl. Nat. Sci. 6(1), 152–158 (2014)
C.C. Ferrari, M.D. Hubinger, Evaluation of the mechanical properties and diffusion coefficients of osmodehydrated melon cubes. Int. J. Food Sci. Technol. 43, 2065–2074 (2008)
P.M. Azoubel, F.E.X. Murr, Mass transfer kinetics of osmotic dehydration of cherry tomato. J. Food Eng. 61, 291–295 (2004)
A.K. Yadav, S.V. Singh, Osmotic dehydration of fruits and vegetables: a review. J. Food Sci. Technol. 51(9), 1654–1673 (2014)
I. Carneiro, S. Carvalho, R. Henrique, L.M. Oliveira, V.V. Tuchin, A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues. J. Biophotonics 12, e201800333 (2019). https://doi.org/10.1002/jbio.201800333
S.K. Jain, R.C. Verna, L.K. Murdia, H.K. Jain, Optimization of process parameters for osmotic dehydration of papaya cubes. J. Food Sci. Technol. 48(2), 211–217 (2011)
D. Tiroutchevalme, V. Sivakumar, J.P. Maran, Mass transfer kinetics during osmotic dehydration of AMLA (Emblica officinalis L.) cubes in sugar solution. Chem. Ind. Chem. Eng. Q. 21(4), 547–559 (2015)
N.K. Rastigi, K.S.M.S. Raghavarao, Function of temperature and concentration during osmotic dehydration. J. Food Eng. 34, 429–440 (1997)
I. Filipović, B. Ćurčić, V. Filipović, M. Nićetin, J. Filipović, V. Knežević, The effects of technological parameters on chicken meat osmotic dehydration process efficiency. J. Food Process. Preserv. 41, e13116-1–e13116-7 (2016)
N.L. Flores-Martínez, M.C.I. Pérez-Pérez, J.M. Oliveros-Muñoz, M.L. López-González, H. Jiménez-Islas, Estimation of diffusion coefficients of essential oil of Pimenta dioica in edible films formulated with aloe vera and gelatin, using Levenberg-Marquardt method. Rev. Mexicana de Ingeniería Química 17(2), 485–506 (2018)
M. Hadipernata, M. Ogawa, Mass transfer and diffusion coefficient of D-Allulose during osmotic dehydration. J. Appl. Food Technol. 3(2), 6–10 (2016)
D. Dimakopoulou-Papazoglou, E. Katsanidis, Mass transfer kinetics during osmotic processing of beef meat using ternary solutions. Food Bioprod. Process. 100, 560–569 (2016)
Sangeeta, B.S. Hathan, Studies on mass transfer and diffusion coefficients in elephant foot yam (Amorphophallus SPP.) during osmotic dehydration in sodium chloride solution. J. Food Process Preserv. 40, 521–530 (2016)
J.H. King, W.M. Townsend, The prolonged storage of donor corneas by glycerine dehydration. Trans. Am. Ophthalmol. Soc. 82, 106–110 (1984)
N. Gupta, P. Upadhyay, Use of glycerol-preserved corneas for corneal transplants. Ind. J. Ophthalmol. 65, 569–573 (2017)
http://www.globalsightnetwork.org/surgeons/glycerolplus-cornea-products. Accessed 22 Apr 2019
M.R. Herson, K. Hamilton, J. White, D. Alexander, S. Poniatowski, A.J. O’Connor, J.A. Werkmeiter, Interaction of preservation methods and radiation sterilization in human skin processing, with particular insight on the impact of the final water content and collagen disruption. Part I: process validation, water activity and collagen changes in tissues cryopreserved or processed using 50, 85 or 98% glycerol solutions. Cell Tissue Bank. 19, 215–217 (2018)
F.A. Elnady, The Elnady technique: an innovative new method for tissue preservation. ALTEX 33(3), 237–242 (2016)
B. Wowk, How cryoprotectants work. Cryonics 28(3), 3–7 (2007). ed. by J. Chapman, Alcor Life Extension Foundation, Scottsdale, AZ
M.S.I. Siddiqui, M. Giasuddin, S.M.Z.H. Chowdhury, M.R. Islam, E.H. Chowdhury, Comparative effectiveness of dimethyl sulphoxide (DMSO) and glycerol as cryoprotective agent in preserving Vero cells. Bangl. Veterin. 32(2), 35–41 (2015)
R. Chen, B. Wang, Y. Liu, R. Lin, J. He, D. Li, A study of cryogenic tissue-engineered liver slices in calcium alginate gel for drug testing. Cryobiology 82, 1–7 (2018)
G.M. Fahy, D.R. MacFarlane, C.A. Angell, H.T. Meryman, Vitrification as an approach to cryopreservation. Cryobiology 21(4), 407–426 (1984)
G.D. Elliot, S. Wang, B.J. Fuller, Cryoprotectants: a review of the actions and applications of cryoprotective solutes that modulate cell recovery from ultra-low temperatures. Cryobiology 76, 74–91 (2017)
P. Kilbride, G.J. Morris, Viscosities encountered during the cryopreservation of dimethyl sulphoxide systems. Cryobiology 76, 92–97 (2017)
X. Zhou, X.M. Liang, J. Wang, P. Du, D. Gao, Theoretical and experimental study of a membrane-based microfluidics for loading and unloading cryoprotective agents. Int. J. Heat Mass Transfer 127, 637–644 (2018)
T.A. Takroni, H. Yu, L. Laouar, A.B. Adesida, J.A.W. Elliott, N.M. Jomha, Ethylene glycol and glycerol loading and unloading in porcine meniscal tissue. Cryobiology 74, 50–60 (2017)
A. Abazari, J.A.W. Elliott, L.E. McGann, R.B. Thompson, MR spectroscopy measurement of the diffusion of dimethyl sulfoxide in articular cartilage and comparison to theoretical predictions. Osteoart. Cartil. 20, 1004–1010 (2012)
J.D. Benson, A.Z. Higgins, K. Desai, A. Eroglu, A toxicity cost function approach to optimal CPA equilibration in tissues. Cryobiology 80, 144–155 (2018)
J.G. Alvarez, B.T. Storey, Evidence that membrane stress contributes more than lipid peroxidation to sublethal cryodamage in cryopreserved human sperm: glycerol and other polyols as sole cryoprotectant. J. Androl. 14(3), 199–209 (1993)
G.D.A. Gastal, B.G. Alves, K.A. Alves, S.O. Paiva, S.G.S. de Tarso, G.M. Ishak, S.T. Bashir, E.L. Gastal, Effects of cryoprotectant agents on equine ovarian biopsy fragments in preparation for cryopreservation. J. Equine Vet. Sci. 53, 86–93 (2017)
D.K. Tuchina, R. Shi, A.N. Bashkatov, E.A. Genina, D. Zhu, Q. Luo, V.V. Tuchin, Ex vivo optical measurements of glucose diffusion kinetics in native and diabetic mouse skin. J. Biophotonics 8(4), 332–346 (2015)
G. Spieles, T. Marx, I. Heschel, G. Rau, Analysis of desorption and diffusion during secondary drying in vacuum freeze-drying of hydroxyethyl starch. Chem. Eng. Process. 34, 351–357 (1995)
L. Weng, S.L. Stott, M. Toner, Exploring dynamics and structure of biomolecules, cryoprotectants, and water using molecular dynamics simulations: implications for biostabilization and biopreservation. Ann. Rev. Biomed. Eng. 21, 1–31 (2019)
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Oliveira, L.M.C., Tuchin, V.V. (2019). Other Applications of Optical Clearing Agents. In: The Optical Clearing Method. SpringerBriefs in Physics. Springer, Cham. https://doi.org/10.1007/978-3-030-33055-2_8
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