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Hyperthermia Study in Breast Cancer Treatment Using a New Applicator

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Applied Informatics (ICAI 2019)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1051))

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Abstract

A study about effects obtained by implementing an electromagnetic hyperthermia (EM) treatment model are presented. The study focus is the breast cancer treatment; this study is perform using an electromagnetic simulation model. A breast was modeled using the conductivity and permittivity of tissues such as fat, skin, lobules and muscle. The distribution of the power density was analyzed for two cases, first the applicator is not aligned with the tumor; second the applicator is aligned with the applicator. The distribution of the power density was analyzed inside the breast model when it was irradiated with two applicators at 2.45 GHz and 5 GHz. The second applicator proposed it is a new prototype of applicator developed in the Groove Gap Waveguide technology (GGW). The power density obtained in lobes, tumor and fat is compared and it was observed that tissues overheating that are close to the tumor can be avoided by optimizing the applicator location. The preliminary results indicate that with the new prototype of applicator developed in the Groove Gap Waveguide technology (GGW) is possible to focus the EM energy. Moreover, the tissues close to the tumor obtain a lower concentration of power density.

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References

  1. Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., Forman, D.: Global cancer statistics. Ca-Cancer J. Clin. 61(2), 69–90 (2011)

    Article  Google Scholar 

  2. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A.: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68(6), 394–424 (2018)

    Article  Google Scholar 

  3. Naz, S., Shahzad, H., Ali, A., Zia, M.: Nanomaterials as nanocarriers: a critical assessment why these are multi-chore vanquisher in breast cancer treatment. Artif. Cells, Nanomedicine Biotechnol. 46(5), 899–916 (2018)

    Article  Google Scholar 

  4. Chalakur-Ramireddy, N.K.R., Pakala, S.B.: Combined drug therapeutic strategies for the effective treatment of Triple Negative. Breast Cancer 38(1), BSR20171357 (2018)

    Google Scholar 

  5. Lee, T.H., Bu, J., Kim, B.H., Poellmann, M.J., Hong, S., Hyun, S.H.: Sub-lethal hyperthermia promotes epithelial-to-mesenchymal-like transition of breast cancer cells: implication of the synergy between hyperthermia and chemotherapy. RSC Adv. 9(1), 52–57 (2019)

    Article  Google Scholar 

  6. Chicheł, A., Skowronek, J., Kubaszewska, M., Kanikowski, M.: Hyperthermia - description of a method and a review of clinical applications. Rep. Pract. Oncol. Radiother. 12(5), 267–275 (2007)

    Article  Google Scholar 

  7. Nguyen, P.T., Abbosh, A.M.: Focusing techniques in breast cancer treatment using non-invasive microwave hyperthermia. ISAP 2015, 1–3 (2015)

    Google Scholar 

  8. Iero, D.A.M., Crocco, L., Isernia, T., Korkmaz, E.: Optimal focused electromagnetic hyperthermia treatment of breast cancer, In: 2016 10th European Conference Antennas Propagation, EuCAP 2016, pp. 1–2 (2016)

    Google Scholar 

  9. Merunka, I., Fiser, O., Vojackova, L., Vrba, J., Vrba, D.: Utilization potential of balanced antipodal Vivaldi antenna for microwave hyperthermia treatment of breast cancer. In: 8th European Conference Antennas Propagation, EuCAP 2014, vol. 6, no. EuCAP, pp. 706–710 (2014)

    Google Scholar 

  10. El, J., et al.: Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer. Clin. Cancer Res. 10(13), 4287–4293 (2004)

    Article  Google Scholar 

  11. Vujaskovic, Z., et al.: A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer. Int. J. Hyperth. 26(5), 514–521 (2010)

    Article  Google Scholar 

  12. Refaat, T., et al.: Hyperthermia and radiation therapy for locally advanced or recurrent breast cancer. Breast 24(4), 418–425 (2015)

    Article  Google Scholar 

  13. Nguyen, P.T., Abbosh, A., Crozier, S.: Microwave hyperthermia for breast cancer treatment using electromagnetic and thermal focusing tested on realistic breast models and antenna arrays. IEEE Trans. Antennas Propag. 63(10), 4426–4434 (2015)

    Article  MathSciNet  Google Scholar 

  14. Kampinga, H.H.: Cell biological effects of hyperthermia alone or combined with radiation or drugs: a short introduction to newcomers in the field. Int. J. Hyperth. 22(3), 191–196 (2006)

    Article  Google Scholar 

  15. Ghaleh, H.E.G., Zarei, L., Motlagh, B.M., Jabbari, N.: Using CuO nanoparticles and hyperthermia in radiotherapy of MCF-7 cell line: synergistic effect in cancer therapy. Artif. Cells Nanomed. Biotechnol. 47(1), 1396–1403 (2019)

    Article  Google Scholar 

  16. Hurwitz, M., Stauffer, P.: Hyperthermia, radiation and chemotherapy: the role of heat in multidisciplinary cancer care. Semin. Oncol. 41(6), 714–729 (2014)

    Article  Google Scholar 

  17. Kitamura, K., Sugimachi, K.: Thermo-radiotherapy combined with chemotherapy for Esophageal tumors. In: Thermoradiotherapy and Thermochemotherapy, 2nd edn., pp. 85–94 (1996)

    Chapter  Google Scholar 

  18. Korkmaz, E., Isık, O., Sagkol, H.: A directive antenna array applicator for focused electromagnetic hyperthermia treatment of breast cancer. In: 2015 9th European Conference Antennas Propagation, vol. 1, pp. 1–4 (2015)

    Google Scholar 

  19. Chakaravarthi, G., Arunachalam, K.: Design and characterisation of miniaturised cavity-backed patch antenna for microwave hyperthermia. Int. J. Hyperth. 31(7), 737–748 (2015)

    Article  Google Scholar 

  20. Curto, S., Ruvio, G., Ammann, M.J., Prakash, P.: A wearable applicator for microwave hyperthermia of breast cancer: performance evaluation with patient-specific anatomic models. In: Proceedings 2015 International Conference Electromagnetic Advance Application ICEAA 2015, pp. 1159–1162 (2015)

    Google Scholar 

  21. Merunka, I., Fiser, O., Vojackova, L., Vrba, J., Vrba, D.: Microwave hyperthermia treatment of neck cancer using eight UWB antennas. In: European Microwave Week 2014: Connecting the Future, EuMW 2014 - Conference Proceedings; EuMC 2014: 44th European Microwave Conference, pp. 790–793 (2014)

    Google Scholar 

  22. Li, J., Wang, X.: Comparison of two small circularly polarized antennas for focused microwave hyperthermia. In: 2019 13th European Conference Antennas Propagation, no. EuCAP, pp. 5–8 (2019)

    Google Scholar 

  23. Stang, J., Haynes, M., Carson, P., Moghaddam, M.: A preclinical system prototype for focused microwave thermal therapy of the breast. IEEE Trans. Biomed. Eng. 59(9), 2431–2438 (2012)

    Article  Google Scholar 

  24. Vrba, D., Vrba, J.: Applicators for local microwave hyperthermia based on metamaterial technology. In: 8th European Conference Antennas Propagation, EuCAP 2014, no. EuCAP, pp. 68–71 (2014)

    Google Scholar 

  25. Tao, Y., Wang, G.: Conformal hyperthermia of superficial tumor with left-handed metamaterial lens applicator. IEEE Trans. Biomed. Eng. 59(12), 3525–3530 (2012)

    Article  Google Scholar 

  26. Nguyen, P.T., Abbosh, A.M., Crozier, S.: Realistic simulation environment to test microwave hyperthermia treatment of breast cancer. In: IEEE Antennas Propagation Society AP-S International Symposium, pp. 1188–1189 (2014)

    Google Scholar 

  27. Guarnizo Mendez, H.F., Polochè Arango, M.A., Pantoja Acosta, J.J.: Hyperthermia Study in Breast Cancer Treatment. In: Figueroa-García, J.C., Villegas, J.G., Orozco-Arroyave, J.R., Maya Duque, P.A. (eds.) WEA 2018. CCIS, vol. 916, pp. 256–267. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00353-1_23

    Chapter  Google Scholar 

  28. Porter, E., Fakhoury, J., Oprisor, R., Coates, M., Popovic, M.: Improved tissue phantoms for experimental validation of microwave breast cancer detection. In: Antennas Propagation (EuCAP), 2010 Proceedings Fourth European Conference, pp. 1–5 (2010)

    Google Scholar 

  29. Nikita, K.S.: Handbook of Biomedical Telemetry, 1st edn. John Wiley & Sons Inc, Hoboken (2014)

    Google Scholar 

  30. Miklavčič, D., Hart, F.X.: Electric properties of tissues. Wiley Encycl. Biomed. Eng., 1–12 (2006)

    Google Scholar 

  31. Gabriel, S., Lau, R.W., Gabriel, C.: The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. Phys. Med. Biol. 41(11), 2251–2269 (1996)

    Article  Google Scholar 

  32. Bohórquez, J.C., et al.: Planar substrate integrated waveguide cavity-backed antenna. IEEE Antennas Wirel. Propag. Lett. 8, 1139–1142 (2009)

    Article  Google Scholar 

  33. Nawaz, M.I., Huiling, Z., Kashif, M.: Substrate integrated waveguide (SIW) to microstrip transition at X-Band. In: 2014 International Conference Circuits, System Control, pp. 61–63 (2014)

    Google Scholar 

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Authors and Affiliations

  1. Universidad El Bosque, Bogotá, Colombia

    H. F. Guarnizo Mendez, J. F. Coronel Rico & T. A. Rubiano Suazo

  2. Universidad de San Buenaventura, Bogotá, Colombia

    M. A. Polochè Arango

Authors
  1. H. F. Guarnizo Mendez
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  2. M. A. Polochè Arango
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  3. J. F. Coronel Rico
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  4. T. A. Rubiano Suazo
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Corresponding author

Correspondence to H. F. Guarnizo Mendez .

Editor information

Editors and Affiliations

  1. Universidad Distrital Francisco Jose de Caldas, Bogota, Colombia

    Hector Florez

  2. Universidad Nacional de Loja, Loja, Ecuador

    Marcelo Leon

  3. Universidad a Distancia de Madrid, Madrid, Spain

    Jose Maria Diaz-Nafria

  4. Universidad Complutense de Madrid, Madrid, Spain

    Simone Belli

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Guarnizo Mendez, H.F., Polochè Arango, M.A., Coronel Rico, J.F., Rubiano Suazo, T.A. (2019). Hyperthermia Study in Breast Cancer Treatment Using a New Applicator. In: Florez, H., Leon, M., Diaz-Nafria, J., Belli, S. (eds) Applied Informatics. ICAI 2019. Communications in Computer and Information Science, vol 1051. Springer, Cham. https://doi.org/10.1007/978-3-030-32475-9_16

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  • DOI: https://doi.org/10.1007/978-3-030-32475-9_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-32474-2

  • Online ISBN: 978-3-030-32475-9

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