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Modified Release Solid Oral Dosage Forms

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Essential Pharmaceutics

Part of the book series: AAPS Introductions in the Pharmaceutical Sciences ((AAPSINSTR))

Abstract

This chapter presents an extensive overview of the concepts of delayed-release, sustained-release, and pulsatile-release for drug delivery. Formulation approaches and delivery technologies are discussed in detail, along with the required performance testing for modified-release dosage forms. Abuse-deterrent technologies are also introduced.

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Further Reading

  1. Suggested readings for the student include the following texts:

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  2. Food and Drug Administration Center for Drugs Evaluation Research. Abuse-deterrent opioids-evaluation and labeling. Maryland: FDA; 2015.

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  3. Conte U, Maggi L, Torre ML, Giunchedi P, La Manna A. Press-coated tablets for time-programmed release of drugs. Biomaterials. 1993;14(13):1017–23.

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  4. Maincent J, Zhang F. Recent advances in abuse-deterrent technologies for the delivery of opioids. Int J Pharm. 2016;510(1):57–72.

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  5. Miller DA, DiNunzio JC, Williams RO III. Advanced formulation design: improving drug therapies for the management of severe and chronic pain. Drug Dev Ind Pharm. 2008;34:117–33.

    Article  CAS  Google Scholar 

  6. Miller DA, Gamba M, Sauer D, Purvis TP, Clemens NT, Williams RO III. Evaluation of the USP dissolution test method a for enteric-coated articles by planar laser-induced fluorescence. Int J Pharm. 2007;330:61072.

    Article  Google Scholar 

  7. Perucca E. Extended-release formulations of antiepileptic drugs: rationale and comparative value. Epilep Curr. 2009;9(6):153–7.

    Article  Google Scholar 

  8. Rhodes CT, Porter SC. Coatings for controlled-release drug delivery systems. Drug Dev Ind Pharm. 1998;24(12):1139–54.

    Article  CAS  Google Scholar 

  9. Roy P, Shahiwala A. Multiparticulate formulation approach to pulsatile drug delivery: current perspectives. J Control Release. 2009;134(2):74–80.

    Article  CAS  Google Scholar 

  10. Verma RK, Krishna DM, Garg S. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J Control Release. 2002;79(1–3):7–27.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. College of Pharmacy, The University of Texas at Austin, Austin, TX, USA

    Ashlee D. Brunaugh, Hugh D. C. Smyth & Robert O. Williams III

Authors
  1. Ashlee D. Brunaugh
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  2. Hugh D. C. Smyth
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  3. Robert O. Williams III
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© 2019 American Association of Pharmaceutical Scientists

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Brunaugh, A.D., Smyth, H.D.C., Williams III, R.O. (2019). Modified Release Solid Oral Dosage Forms. In: Essential Pharmaceutics. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-31745-4_4

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