Abstract
-
Transfusion-associated lung injury (TRALI) is defined as the onset of acute, non-cardiogenic pulmonary edema within 6 h of transfusion and the absence of pre-existing acute lung injury
-
Diagnostic findings are hypoxia (O2 saturation < 90% in room air), a PaO2/FiO2 ratio < 300 mmHg and new bilateral pulmonary infiltrates.
-
With O2 supplementation, up to 72% of cases of TRALI resolve within 48–96 h
-
High dose steroids have no benefit in TRALI
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kleinman S, Povosky M. TRALI: mechanisms, management and prevention. Bethseda: AABB Press; 2008.
Eder A, Dy B, Perez J, Rambaud M, Benjamin R. The residual risk of transfusion-related acute lung injury at the American Red Cross (2008–2011): limitations of a predominantly male-donor plasma mitigation strategy. Transfusion. 2013;53:1442–9.
Nagawa M, Toy P. Acute and transient decrease in neutrophil count in transfusion-related acute lung injury: cases at one hospital. Transfusion. 2004;44:1689–94.
Stein APDV, Alexander P. Antibody-mediated transfusion-related acute lung injury; from discovery to prevention. Br J Haematol. 2015;170:597–614.
Reil A, Keller-Stanislaski B, S SG, Bux JE. Specificities of leucocyte alloantibodies in transfusion-related acute lung injury and results of leucocyte antibody screening of blood donors. Vox Sang. 2008;95:313–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Cooling, L. (2020). Acute Dyspnea After Platelet Transfusion. In: Rahmani, F., Rezaei, N. (eds) Pediatric Autoimmunity and Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-26280-8_47
Download citation
DOI: https://doi.org/10.1007/978-3-030-26280-8_47
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-26279-2
Online ISBN: 978-3-030-26280-8
eBook Packages: MedicineMedicine (R0)