Abstract
I met Claes Dohlman for the first time at an antiviral conference in 1963 sponsored by Allergan Pharmaceuticals in Irvine, California. We had both been invited to discuss the first antiviral drug effective against a human virus, herpes simplex. The medication was 5-iodo-2′-deoxyuridine, or IDU. It had initially been reported by Kaufman, Nesburn, and Maloney in 1962 [1], while Herbert Kaufman was an ophthalmology resident at Massachusetts Eye and Ear Infirmary.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kaufman HE, Nesburn AB, Mahoney ED. IDU therapy of herpes simplex keratitis. Arch Ophthalmol. 1962;67:583–91.
Laibson PR, Sery TW, Leopold IH. The treatment of herpetic keratitis with IDU. Arch Ophthalmol. 1963;70:52–8.
Gunderson T. Herpes cornea with special reference to its treatment with strong solution of iodine. ArchOphthalmol. 1936;15:225–44.
Sery T. Chemotherapy of virus infections. In: IntOphthClin, 1961, vol. 1; 1961. p. 99–110.
Laibson PR, Leopold IH. An evaluation of double-Blind IDU therapy in 100 cases of herpetic keratitis. Trans AmAcadOphthalmolOtolaryngol. 1964:22–33.
Carroll J, Martola EL, Laibson PR, Dohlman CH. The recurrence of herpetic keratitis following IDU therapy. Am JOphthalmol. 1967;63:103–7.
Laibson PR, Kibrick S. Reactivation of herpetic keratitis by epinephrine in rabbit. Arch Ophthalmol. 1966;75:254–60.
Laibson PR, Kibrick S. Reactivation of herpetic keratitis in rabbits II. Repeated reactivations in the same host. Arch Ophthalmol. 1967;77:244–8.
Pavan-Langston D, Dohlman CH. A double-Blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis. Am J Ophthalmol. 1972;74:81–8.
Hyndiuk RA, Hull DS, Schultz R, et al. Adenine arabinoside in IDU unresponsive and IDU intolerant herpetic keratitis. Am J Ophthalmol. 1975;79:655–8.
Kaufman HE, Heidelberger C. Therapeutic antiviral action of 5 trifluoro- methyl-2 deoxyuridine in herpes simplex keratitis. Science. 1964;145:585.
Parlato CJ, Cohen EJ, Sakauye CM, et al. Role of debridement and trifluridine (Trifluorothymidine) in herpes simplex dendritic keratitis. Arch Ophthalmol. 1985;103:673–5.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Laibson, P.R. (2020). Herpetic Keratitis: The Genesis of a Career in the Early Days of HSV Keratitis Research. In: Colby, K., Dana, R. (eds) Foundations of Corneal Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-25335-6_4
Download citation
DOI: https://doi.org/10.1007/978-3-030-25335-6_4
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-25334-9
Online ISBN: 978-3-030-25335-6
eBook Packages: MedicineMedicine (R0)