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Role of HSP in the Treatment of Internal Diseases

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Heat Shock Proteins in Neuroscience

Part of the book series: Heat Shock Proteins ((HESP,volume 20))

Abstract

Heat shock proteins (HSP) take their name from their apparent accidental discovery following transient heat stress in the salivary glands of Drosophila melanogaster (5 °C above normal temperature) HSP. All cells, from bacteria to human, have a common, complicated response to stress that protects them from injury. HSP play a major role in that response. HSP, protect the structure of normal proteins and plays a role in repairing or removing damaged ones. HSP response shows similar effects when faced with stressor conditions, such as oxidative stress, glucose deprivation, and infection, which lead to the misfolding of intracellular proteins. HSP participate in protein prevention from denaturation, repair, degradation of non-repairable ones, cell signal and response formation in the stress situations. Because of their important function in both physiological and pathological fields, it is possible to develop treatment strategies in many areas related to internal medicine. Current Data strongly supports efforts to target HSP in many diseases, mostly oncology. Drugs that make chaperone antagonism, such as Hsp90 inhibitors, reverse the damage caused by overexpressed HSP by helping to break down oncogenes. Treatment with HSP vaccines or HSP antagonists are in phase III trials in both inflammatory diseases and cancer treatment. Further studies will enable it to take its place in the treatment of inflammatory diseases and cancer.

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Abbreviations

AGEs:

advanced glycation end products

Apaf1:

apoptotic protease activating factor 1

DED:

death effector domain

eNOS:

endothelial nitric oxide synthase

GGA:

geranylgeranylacetone

GHRP-6:

growth hormone releasing peptide-6

GM:

geldanamycin

HSF:

heat shock factor

HSP:

heat shock proteins

HSPPC-96:

heat shock protein-peptide complex-96

iNOS:

inducible nitric oxide synthase

MHC:

major histocompatibility complex

NO:

nitric oxide

NOD2:

nucleotide-binding oligomerization domain-containing protein 2

NSAID:

non steroid antiinflammatory drug

NSCLC:

non-small cell lung cancer

Pg:

prostaglandin

RD:

radicicol

ROS:

reactive oxygen species

Tg2:

tissue transglutaminase 2

TLR4:

toll-like receptor 4

Tregs:

regulatory T cells

WIS:

water immersion stress

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Acknowledgements

We want to thank Ozgur Golgelioglu for his help preparing the review.

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Authors and Affiliations

  1. Division of İnternal Medicine, SB University Izmir Bozyaka Training and Research Hospital, Izmir, Turkey

    Ozden Yildirim Akan

  2. Division of Neurology, SB University Izmir Bozyaka Training and Research Hospital, Izmir, Turkey

    Pinar Ortan

  3. Division of Physiology, Dokuz Eylul University Medical Faculty, İzmir, Turkey

    Ferda Hosgorler

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  1. Ozden Yildirim Akan
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  2. Pinar Ortan
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  3. Ferda Hosgorler
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  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Akan, O.Y., Ortan, P., Hosgorler, F. (2019). Role of HSP in the Treatment of Internal Diseases. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins in Neuroscience. Heat Shock Proteins, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-030-24285-5_16

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