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Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs

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Heart of the Matter

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Abstract

This chapter will begin by briefly establishing the global clinical burden of heart failure (HF) and limitations of current treatment regimens. The use of left ventricular assist devices (LVADs) in advanced HF will then be explored, including a discussion of the underlying principles of mechanical unloading. We will then evaluate the emerging evidence of the role that exosomes and microRNAs may have in the diagnosis and treatment of cardiovascular diseases, including myocardial infarction.

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Author information

Authors and Affiliations

  1. St George’s, University of London, London, UK

    Samuel Guymer

  2. National Heart and Lung Institute, Myocardial Function, Imperial College London, London, UK

    Samuel Guymer & Mayooran Shanmuganathan

  3. Cardiovascular Medicine, University of Oxford, Oxford, UK

    Mayooran Shanmuganathan

Authors
  1. Samuel Guymer
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  2. Mayooran Shanmuganathan
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Correspondence to Mayooran Shanmuganathan .

Editor information

Editors and Affiliations

  1. National Heart & Lung Institute, Imperial College London, London, UK

    Cesare Terracciano

  2. Imperial College London & St George’s Medical School, London, UK

    Samuel Guymer

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Guymer, S., Shanmuganathan, M. (2019). Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs. In: Terracciano, C., Guymer, S. (eds) Heart of the Matter. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-24219-0_14

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