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Bioprinting Vasculature

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3D Bioprinting in Medicine

Abstract

Despite the extensive research in fabricating tissue-engineered vascularized constructs, emulating the native architecture with intricate microvascular networks in vitro remains challenging, which limits clinical applications. The 3D bioprinting technique is a promising approach for overcoming the limitations posed by the classical tissue engineering strategies. The new generation of bioprinted vascularized tissue constructs facilitates the high spatial control of cell allocation, alignment, and maturation and vessel stabilization as a result of the efficient diffusion of oxygen, nutrients, and (optionally) growth factors, thereby enhancing the metabolic activity of cells. Moreover, the bioprinted vascularized construct accelerates its integration with the host tissue upon implantation, promoting rapid microvascular formation and tissue regeneration. Additionally, the flexibility to fabricate cell-laden, multi-material, and anatomically shaped vascular grafts and vascularized tissue constructs encourages the development of modalities for screening new therapeutic drugs and for using as an in vitro disease model. In this chapter, we briefly discuss the need for using tissue-engineered vascularized constructs and summarize the different types of biomaterials and conventional approaches toward it. We also introduce the advent of 3D bioprinting in developing 3D vascularized constructs and focus on its applications in tissue regeneration and as a platform for drug discovery and testing.

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Acknowledgements

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2015R1A6A3A04059015) and the MSIP (Ministry of Science, ICT and Future Planning), Korea, under the “ICT Consilience Creative Program” (IITP-R0346-16-1007) supervised by the IITP (Institute for Information & communications Technology Promotion).

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Authors and Affiliations

  1. Department of Creative IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea

    Sanskrita Das & Jinah Jang

  2. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea

    Jinah Jang

  3. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Republic of Korea

    Jinah Jang

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  1. Sanskrita Das
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  2. Jinah Jang
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Correspondence to Jinah Jang .

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  1. Otto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ, USA

    Murat Guvendiren

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Das, S., Jang, J. (2019). Bioprinting Vasculature. In: Guvendiren, M. (eds) 3D Bioprinting in Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-23906-0_4

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