Abstract
18F-NaF PET/CT has established its place in the oncologic clinical routine. It has essential role in initial staging, detection of suspected first osseous metastasis, suspected progression of osseous metastasis, or treatment monitoring in many types of cancer, such as prostate, lung, and breast cancer.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Segall G, Delbeke D, Stabin MG, et al. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51:1813–20.
Gareen IF, Hillner BE, Hanna L, et al. Hospice admission and survival after 18F-fluoride PET performed for evaluation of osseous metastatic disease in the national oncologic PET registry. J Nucl Med. 2018;59:427–33.
Oyen W, Sundram F, Haug AR, et al. Radium-223 dichloride (Ra-223) for the treatment of metastatic castration-resistant prostate cancer: optimizing clinical practice in nuclear medicine centers. J Oncopathol. 2015;3:1–25.
Sorto G, Gallichio R, Pellegrino T, et al. Impact of 18F-fluoride PET/CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP. Nucl Med Biol. 2013;40:518–23.
Even-Sapir E, Metser U, Mishani E, et al. The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy; single- and multi-field-of-view SPECT; 18F-fluoride PET; and 18Ffluoride PET/CT. J Nucl Med. 2006;47:287–97.
Kairemo K, Milton DR, Etchebehere E, et al. Final outcome of 223Ra-therapy and the role of 18F-fluoride-PET in response evaluation in metastatic castration-resistant prostate cancer–a single institution experience. Curr Radiopharm. 2018;11:152–7.
Etchebehere EC, Araujo JC, Fox PS, Swanston NM, Macapinlac HA, Rohren EM. Prognostic factors in patients treated with 223Ra: the role of skeletal tumor turden on baseline 18Ffluoride PET/CT in predicting overall survival. J Nucl Med. 2015;56:1177–84.
von Eyben FE, Kairemo K, Kiljunen T, Joensuu T. Planning of external beam radiotherapy for prostate cancer guided by PET/CT. Curr Radiopharm. 2015;8:19–31.
Hillner BE, Siegel BA, Hanna L, Duan F, Shields AF, Coleman RE. Impact of 18F-fluoride PET in patients with known prostate cancer: initial results from the national oncologic PET registry. J Nucl Med. 2014;55:574–81.
Langsteger W, Balogova S, Huchet V, et al. Fluorocholine (18F) and sodium fluoride (18F) PET/CT in the detection of prostate cancer: prospective comparison of diagnostic performance determined by masked reading. Q J Nucl Med Mol Imaging. 2011;55:448–57.
Scher HI, Sawyers CL. Biology of progressive, castration resistant prostate cancer: directed therapies targeting the androgen receptor signaling axis. J Clin Oncol. 2005;23:8253–61.
Kairemo K, Joensuu T. Radium-223-dichloride in castration resistant metastatic prostate cancer-preliminary results of the response evaluation using F-18-fluoride PET/CT. Diagnostics (Basel). 2015;5:413–27.
Etchebehere E, Brito AE, Rezaee A, et al. Therapy assessment of bone metastatic disease in the era of 223radium. Eur J Nucl Med Mol Imaging. 2017;44(Suppl 1):84–96.
Taube T, Elomaa I, Blomqvist C, Beneton MN, Kanis JA. Histomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancer. Bone. 1994;15:161–6.
WAM B, van der Zant FM, Wondergem M, Knol RJJ. Accuracy of 18F-NaF PET/CT in bone metastasis detection and its effect on patient management in patients with breast carcinoma. Nucl Med Commun. 2018;39(4):325–33.
Brito AE, Santos A, Sasse AD, et al. 18F-Fluoride PET/CT tumor burden quantification predicts survival in breast cancer. Oncotarget. 2017;8(22):36001–11.
Azad G, Siddique MM, Taylor B, et al. Does measurement of 18F-fluoride metabolic flux improve response assessment of breast cancer bone metastases compared with standardised uptake values in 18F-fluoride PET/CT? J Nucl Med. 2019;60:322. https://doi.org/10.2967/jnumed.118.208710.
Peterson LM, O’Sullivan J, Wu QV, et al. Prospective study of serial 18F-FDG PET and 18F-fluoride (18F-NaF) PET to predict time to skeletal related events, time-to-progression, and survival in patients with bone-dominant metastatic breast cancer. J Nucl Med. 2018;59:1823. https://doi.org/10.2967/jnumed.118.211102.
Rao L, Zong Z, Chen Z, et al. 18F-labeled NaF PET/CT in detection of bone metastases in patients with preoperative lung cancer. Medicine (Baltimore). 2016;95:e3490.
Lee H, Lee WW, Park SY, Kim SE. F-18 sodium fluoride positron emission tomography/computed tomography for detection of thyroid cancer bone metastasis compared with bone scintigraphy. Korean J Radiol. 2016;17:281–8. https://doi.org/10.3348/kjr.2016.17.2.281.
Ota N, Kato K, Iwano S, et al. Comparison of 18F-fluoride PET/CT, 18F-FDG PET/CT and bone scintigraphy (planar and SPECT) in detection of bone metastases of differentiated thyroid cancer: a pilot study. Br J Radiol. 2014;87:20130444.
Schirrmeister H, Buck A, Guhlmann A, Reske SN. Anatomical distribution and sclerotic activity of bone metastases from thyroid cancer assessed with F-18 sodium fluoride positron emission tomography. Thyroid. 2001;11:677–83.
Gerety EL, Lawrence EM, Wason J, et al. Prospective study evaluating the relative sensitivity of 18F-NaF PET/CT for detecting skeletal metastases from renal cell carcinoma in comparison to multidetector CT and 99mTc-MDP bone scintigraphy, using an adaptive trial design. Ann Oncol. 2015;26:2113–8.
Sharma P, Karunanithi S, Chakraborty PS, et al. 18F-fluoride PET/CT for detection of bone metastasis in patients with renal cell carcinoma: a pilot study. Nucl Med Commun. 2014;35:1247–53.
Duarte PS, de Castroneves LA, Sado HN, et al. Bone and calcified soft tissue metastases of medullary thyroid carcinoma better characterized on 18F-fluoride PET/CT than on 68Ga-Dotatate PET/CT. Nucl Med Mol Imaging. 2018;52:318–23. https://doi.org/10.1007/s13139-018-0527-8.
Duarte PS, Marin JFG, Carvalho D, et al. Brain metastasis of medullary thyroid carcinoma without macroscopic calcification detected first on 68Ga-Dotatate and then on 18F-fluoride PET/CT. Clin Nucl Med. 2018;43:623–4.
do Vale RH, Marin JF, Duarte PS, Sapienza MT, Buchpiguel CA. Visualization of lymph nodal and hepatic metastases of medullary thyroid carcinoma on 18F-fluoride PET/CT. Clin Nucl Med. 2015;40:895–6.
Basu S, Ranade R, Thapa P. 177Lu-DOTATATE versus 177Lu-EDTMP versus cocktail/sequential therapy in bone-confined painful metastatic disease in medullary carcinoma of the thyroid and neuroendocrine tumour: can semiquantitative comparison of 68Ga-DOTATATE and 18F-fluoride PET/CT aid in personalized treatment decision making in selecting the best therapeutic option? Nucl Med Commun. 2016;37:100–2.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Kairemo, K., Macapinlac, H.A. (2020). Sodium Fluoride Imaging in Oncology. In: Kairemo, K., Macapinlac, H.A. (eds) Sodium Fluoride PET/CT in Clinical Use. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-030-23577-2_3
Download citation
DOI: https://doi.org/10.1007/978-3-030-23577-2_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-23576-5
Online ISBN: 978-3-030-23577-2
eBook Packages: MedicineMedicine (R0)