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Combining Radiosurgery and Systemic Therapies for Treatment of Brain Metastases

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Central Nervous System Metastases

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Abstract

For decades, the treatment of brain metastases was limited to surgery, radiation, and, occasionally, chemotherapy. Advances in the understanding of oncogenic molecular pathways, the blood–brain barrier, focused radiation, and immunology have built a new foundation on how we think about and treat brain metastases. This chapter will review systemic treatments, with emphases on targeted therapy and immunotherapy, and their use in combination with radiosurgery. The substantial, yet still growing, literature will be presented and reviewed, along with data and recommendations from our own institution.

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Authors and Affiliations

  1. Department of Neurosurgery, Yale University, New Haven, CT, USA

    Veronica Chiang & Stephanie Cheok

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  1. Veronica Chiang
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  2. Stephanie Cheok
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Correspondence to Veronica Chiang .

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Editors and Affiliations

  1. Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA

    Manmeet Ahluwalia

  2. Department of Neurosurgery and Neuro-Oncology, Clairval Hospital Center, Ramsay-Générale de Santé, Marseille, France, Neurophysiopathology Institute, Aix-Marseille Université, Marseille, France

    Philippe Metellus

  3. Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy

    Riccardo Soffietti

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Chiang, V., Cheok, S. (2020). Combining Radiosurgery and Systemic Therapies for Treatment of Brain Metastases. In: Ahluwalia, M., Metellus, P., Soffietti, R. (eds) Central Nervous System Metastases. Springer, Cham. https://doi.org/10.1007/978-3-030-23417-1_19

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