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Recurrent Cold Suppurative Granulomatous Lymphadenitis

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Pediatric Immunology

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Abstract

Cold abscesses are a hallmark of defects of the innate immune system including hyper-IgE syndrome and chronic granulomatous disease

MyD88 is a molecular adaptor acting downstream to all TLR, except TLR3, and downstream to IL-1R

MyD88 deficiency is associated with selective increased susceptibility to invasive pyogenic bacterial infections

Low fever and mild increase of systemic inflammatory markers in contrast with a severe clinical course of infectious diseases should rise the suspicion of MyD88 deficiency

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Authors and Affiliations

  1. Department of Translational Medical Sciences, Unit of Immunology, Federico II University of Naples, Naples, Italy

    Giuliana Giardino, Emilia Cirillo, Vera Gallo & Claudio Pignata

Authors
  1. Giuliana Giardino
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  2. Emilia Cirillo
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  3. Vera Gallo
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  4. Claudio Pignata
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Corresponding author

Correspondence to Claudio Pignata .

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Editors and Affiliations

  1. Department of Immunology, School of Medicine, Research Center for Immunodeficiencies (RCID)Children’s Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Nima Rezaei

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Giardino, G., Cirillo, E., Gallo, V., Pignata, C. (2019). Recurrent Cold Suppurative Granulomatous Lymphadenitis. In: Rezaei, N. (eds) Pediatric Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-21262-9_68

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  • DOI: https://doi.org/10.1007/978-3-030-21262-9_68

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21261-2

  • Online ISBN: 978-3-030-21262-9

  • eBook Packages: MedicineMedicine (R0)

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