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Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells

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Abstract

A growing number of patients require treatments in the field of oral and maxillofacial surgery, because of several different cues such as traumatic injuries, degenerative diseases, and cancer-related surgical treatments.

Since 1990, regenerative techniques were focused on the use of platelet concentrates and growth factors; in the following years, the development of new biomaterials introduced the era of tissue engineering, but the most fruitful advancement was represented by the introduction of mesenchymal stem cells (MSCs) that completely revolutionized tissue and organ regeneration.

This chapter aims to describe the most important advancements of regenerative technologies involved in oral and maxillofacial surgery, focusing on the wide application of MSCs and on the role of the newly discovered oral-derived MSCs in clinical uses.

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Author information

Authors and Affiliations

  1. Tecnologica Research Institute, Biomedical Section, Crotone, Italy

    Marco Tatullo, Francesca Palmieri & Bruna Codispoti

  2. Marrelli Health, Clinical Research Unit, Crotone, Italy

    Massimo Marrelli & Francesco Paduano

  3. University of Naples “Federico II”, Naples, Italy

    Sandro Rengo, Carlo Rengo & Gianrico Spagnuolo

Authors
  1. Marco Tatullo
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  2. Massimo Marrelli
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  3. Francesco Paduano
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  4. Francesca Palmieri
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  5. Sandro Rengo
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  6. Carlo Rengo
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  7. Gianrico Spagnuolo
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  8. Bruna Codispoti
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Corresponding author

Correspondence to Marco Tatullo .

Editor information

Editors and Affiliations

  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Tatullo, M. et al. (2019). Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19958-6_29

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