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Lumbar Herniated Nucleus Pulposus

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Minimally Invasive Spine Surgery

Abstract

This chapter will discuss the pathophysiology, exam, diagnosis, and management of lumbar disc herniation (LDH). In brief, LDH is a common pathology that affects a significant percentage of the population. The natural history of LDH is favorable, and excellent results have been obtained following conservative management. Anti-inflammatory medications, physical therapy, and epidural steroid injections make up the mainstay of nonoperative treatment. However, large-scale SPORT suggests that patients managed with discectomy may have a more favorable outcome when compared to conservative treatment. A “mini-open” technique is the most common modality of discectomy performed; however, minimally invasive approaches are gaining popularity. The use of a tubular retractor system typifies the modern minimally invasive approach. A number of randomized controlled trials comparing open discectomy to minimally invasive microdiscectomy have been performed, demonstrating that both techniques are equally effective at relieving pain and have comparable reherniation rates. Overall complication rates are similar between open and minimally invasive approaches; however, the number of incidental durotomies is higher with minimally invasive approaches, likely reflective of the learning curve. Minimally invasive approaches offer the potential benefit of less soft tissue trauma and faster recovery; however, they are technically demanding. Excellent results can be obtained with either a minimally invasive or open approach.

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References

  1. Ambrossi GLG, McGirt MJ, Sciubba DM, Witham TF, Wolinsky J-P, Gokaslan ZL, Long DM. Recurrent lumbar disc herniation after single-level lumbar discectomy: incidence and health care cost analysis. Neurosurgery. 2009;65:574–8; discussion 578.

    Article  PubMed  Google Scholar 

  2. Pugely AJ, Gao Y, Martin CT, Callaghan JJ, Weinstein SL, Marsh JL. The effect of resident participation on short-term outcomes after orthopaedic surgery. Clin Orthop Relat Res. 2014;472:2290–300.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Carragee EJ, Golish SR. In: Rao RD, Smuck M, editors. Orthopaedic knowledge update 4: spine. Rosemont: Amer Academy of Orthopaedic; 2012. [ISBN 13: 978-0892037377].

    Google Scholar 

  4. Ma D, Liang Y, Wang D, Liu Z, Zhang W, Ma T, Zhang L, Lu X, Cai Z. Trend of the incidence of lumbar disc herniation: decreasing with aging in the elderly. Clin Interv Aging. 2013;8:1047–50.

    PubMed  PubMed Central  Google Scholar 

  5. Mixter WJ, Barr JS. Rupture of the intervertebral disc with involvement of the spinal canal. J Neurosurg. 1964;21:74–81.

    Article  Google Scholar 

  6. Postacchini F, Postacchini R. Operative management of lumbar disc herniation : the evolution of knowledge and surgical techniques in the last century. Acta Neurochir Suppl. 2011;108:17–21.

    Article  CAS  PubMed  Google Scholar 

  7. Caspar W. A new surgical procedure for lumbar disc herniation causing less tissue damage through a microsurgical approach. In: Lumbar disc adult hydrocephalus. Berlin/Heidelberg: Springer; 1977. p. 74–80.

    Chapter  Google Scholar 

  8. Foley KT. Microendoscopic discectomy. Tech Neurosurg. 1997;3:301–7.

    Google Scholar 

  9. Clark AJ, Safaee MM, Khan NR, Brown MT, Foley KT. Tubular microdiscectomy: techniques, complication avoidance, and review of the literature. Neurosurg Focus. 2017;43:E7.

    Article  PubMed  Google Scholar 

  10. Arts M, Brand R, van der Kallen B, Lycklama à Nijeholt G, Peul W. Does minimally invasive lumbar disc surgery result in less muscle injury than conventional surgery? A randomized controlled trial. Eur Spine J. 2011;20:51–7.

    Article  PubMed  Google Scholar 

  11. Grunhagen T, Shirazi-Adl A, Fairbank JCT, Urban JPG. Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites. Orthop Clin North Am. 2011;42:465–77–vii.

    Article  PubMed  Google Scholar 

  12. White AA III, Panjabi MM. Clinical biomechanics of the spine. 2nd ed. Philadelphia: Lippincott; 1990.

    Google Scholar 

  13. Takegami K, An HS, Kumano F, Chiba K, Thonar EJ, Singh K, Masuda K. Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis. Spine J. 2005;5:231–8.

    Article  PubMed  Google Scholar 

  14. Takatalo J, Karppinen J, Niinimäki J, Taimela S, Näyhä S, Järvelin M-R, Kyllönen E, Tervonen O. Prevalence of degenerative imaging findings in lumbar magnetic resonance imaging among young adults. Spine. 2009;34:1716–21.

    Article  PubMed  Google Scholar 

  15. Stefanakis M, Al-Abbasi M, Harding I, Pollintine P, Dolan P, Tarlton J, Adams MA. Annulus fissures are mechanically and chemically conducive to the ingrowth of nerves and blood vessels. Spine. 2012;37:1883–91.

    Article  PubMed  Google Scholar 

  16. Bobechko WP, Hirsch C. Auto-immune response to nucleus pulposus in the rabbit. J Bone Joint Surg Br. 1965;47:574–80.

    Article  CAS  PubMed  Google Scholar 

  17. Gertzbein SD, Tait JH, Devlin SR. The stimulation of lymphocytes by nucleus pulposus in patients with degenerative disk disease of the lumbar spine. Clin Orthop Relat Res. 1977:149–54.

    Google Scholar 

  18. Saal JA, Saal JS, Herzog RJ. The natural history of lumbar intervertebral disc extrusions treated nonoperatively. Spine. 1990;15:683–6.

    Article  CAS  PubMed  Google Scholar 

  19. Kang JD, Georgescu HI, McIntyre-Larkin L, Stefanovic-Racic M, Donaldson WF, Evans CH. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine. 1996;21:271–7.

    Article  CAS  PubMed  Google Scholar 

  20. Olmarker K, Rydevik B, Nordborg C. Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots. Spine. 1993;18:1425–32.

    Article  CAS  PubMed  Google Scholar 

  21. Rajasekaran S, Bajaj N, Tubaki V, Kanna RM, Shetty AP. ISSLS prize winner: the anatomy of failure in lumbar disc herniation: an in vivo, multimodal, prospective study of 181 subjects. Spine. 2013;38:1491–500.

    Article  CAS  PubMed  Google Scholar 

  22. Fardon DF, Williams AL, Dohring EJ, Murtagh FR, Gabriel Rothman SL, Sze GK. Lumbar disc nomenclature: version 2.0: recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology. Spine J. 2014;14:2525–45.

    Article  PubMed  Google Scholar 

  23. Li Y, Fredrickson V, Resnick DK. How should we grade lumbar disc herniation and nerve root compression? A systematic review. Clin Orthop Relat Res. 2015;473:1896–902.

    Article  PubMed  Google Scholar 

  24. Hsu K, Zucherman J, Shea W, Kaiser J, White A, Schofferman J, Amelon C. High lumbar disc degeneration. Incidence and etiology. Spine. 1990;15:679–82.

    Article  CAS  PubMed  Google Scholar 

  25. Daghighi MH, Pouriesa M, Maleki M, Fouladi DF, Pezeshki MZ, Mazaheri Khameneh R, Bazzazi AM. Migration patterns of herniated disc fragments: a study on 1,020 patients with extruded lumbar disc herniation. Spine J. 2014;14:1970–7.

    Article  PubMed  Google Scholar 

  26. Kreiner DS, Hwang SW, Easa JE, et al. An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy. Spine J. 2014;14:180–91.

    Article  PubMed  Google Scholar 

  27. Radcliff K, Hilibrand A, Lurie JD, Tosteson TD, Delasotta L, Rihn J, Zhao W, Vaccaro A, Albert TJ, Weinstein JN. The impact of epidural steroid injections on the outcomes of patients treated for lumbar disc herniation: a subgroup analysis of the SPORT trial. J Bone Joint Surg Am. 2012;94:1353–8.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Hughes SPF, Freemont AJ, Hukins DWL, McGregor AH, Roberts S. The pathogenesis of degeneration of the intervertebral disc and emerging therapies in the management of back pain. J Bone Joint Surg Br. 2012;94:1298–304.

    Article  CAS  PubMed  Google Scholar 

  29. Shih P, Smith TR, Fessler RG, Song JK. Minimally invasive discectomy for the treatment of disc herniation causing cauda equina syndrome. J Clin Neurosci. 2011;18:1219–23.

    Article  PubMed  Google Scholar 

  30. van der Windt DA, Simons E, Riphagen II, et al. Physical examination for lumbar radiculopathy due to disc herniation in patients with low-back pain. Cochrane Database Syst Rev. 2010;138:CD007431.

    Google Scholar 

  31. Weiner BL, Zibis A. In: Wiesel SW, editor. Lumbar discectomy. Operative techniques in orthopaedic surgery. 2nd ed. Philadelphia: Lippincott Williams and Wilkins; 2015. [ISBN 13: 9781451193145].

    Google Scholar 

  32. Lee JH, Lee S-H. Physical examination, magnetic resonance image, and electrodiagnostic study in patients with lumbosacral disc herniation or spinal stenosis. J Rehabil Med. 2012;44:845–50.

    Article  PubMed  Google Scholar 

  33. Hahne AJ, Ford JJ, McMeeken JM. Conservative management of lumbar disc herniation with associated radiculopathy: a systematic review. Spine. 2010;35:E488–504.

    Article  PubMed  Google Scholar 

  34. Oosterhuis T, Costa LOP, Maher CG, de Vet HCW, van Tulder MW, Ostelo RWJG. Rehabilitation after lumbar disc surgery. Cochrane Database Syst Rev. 2014;9:CD003007.

    Google Scholar 

  35. Manchikanti L, Falco FJE, Pampati V, Cash KA, Benyamin RM, Hirsch JA. Cost utility analysis of caudal epidural injections in the treatment of lumbar disc herniation, axial or discogenic low back pain, central spinal stenosis, and post lumbar surgery syndrome. Pain Physician. 2013;16:E129–43.

    PubMed  Google Scholar 

  36. Manchikanti L, Benyamin RM, Falco FJE, Kaye AD, Hirsch JA. Do epidural injections provide short- and long-term relief for lumbar disc herniation? A systematic review. Clin Orthop Relat Res. 2015;473:1940–56.

    Article  PubMed  Google Scholar 

  37. Radcliff KE, Kepler CK, Jakoi A, Sidhu GS, Rihn J, Vaccaro AR, Albert TJ, Hilibrand AS. Adjacent segment disease in the lumbar spine following different treatment interventions. Spine J. 2013;13:1339–49.

    Article  PubMed  Google Scholar 

  38. Abdi S, Datta S, Lucas LF. Role of epidural steroids in the management of chronic spinal pain: a systematic review of effectiveness and complications. Pain Physician. 2005;8:127–43.

    PubMed  Google Scholar 

  39. Centers for Disease Control and Prevention (CDC). Multistate outbreak of fungal infection associated with injection of methylprednisolone acetate solution from a single compounding pharmacy—United States, 2012. MMWR Morb Mortal Wkly Rep. 2012;61:839–42.

    Google Scholar 

  40. Bromage PR, Benumof JL. Paraplegia following intracord injection during attempted epidural anesthesia under general anesthesia. Reg Anesth Pain Med. 1998;23:104–7.

    Article  CAS  PubMed  Google Scholar 

  41. Freeman BJC, Ludbrook GL, Hall S, Cousins M, Mitchell B, Jaros M, Wyand M, Gorman JR. Randomized, double-blind, placebo-controlled, trial of transforaminal epidural etanercept for the treatment of symptomatic lumbar disc herniation. Spine. 2013;38:1986–94.

    Article  PubMed  Google Scholar 

  42. Weber H. Lumbar disc herniation. A controlled, prospective study with ten years of observation. Spine. 1983;8:131–40.

    Article  CAS  PubMed  Google Scholar 

  43. Lurie JD, Tosteson TD, Tosteson ANA, Zhao W, Morgan TS, Abdu WA, Herkowitz H, Weinstein JN. Surgical versus non-operative treatment for lumbar disc herniation: eight-year results for the spine patient outcomes research trial (SPORT). Spine. 2014;39:3–16.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Rubin DB. On the limitations of comparative effectiveness research. Stat Med. 2010;29:1991–5.

    Article  PubMed  Google Scholar 

  45. Javid MJ, Nordby EJ. Lumbar chymopapain nucleolysis. Neurosurg Clini N Am. 1996;7:17–27.

    Article  CAS  Google Scholar 

  46. Meinert CL. Clinical trials: design, conduct, and analysis. 2nd ed. New York: Oxford University Press; 2012. [ISBN 13: 978-0195387889].

    Google Scholar 

  47. Wittenberg RH, Oppel S, Rubenthaler FA, Steffen R. Five-year results from chemonucleolysis with chymopapain or collagenase: a prospective randomized study. Spine. 2001;26:1835–41.

    Article  CAS  PubMed  Google Scholar 

  48. Mathews HH, Long BH. Minimally invasive techniques for the treatment of intervertebral disk herniation. J Am Acad Orthop Surg. 2002;10:80–5.

    Article  PubMed  Google Scholar 

  49. Quigley MR, Maroon JC. Automated percutaneous discectomy. Neurosurg Clin N Am. 1996;7:29–35.

    Article  CAS  PubMed  Google Scholar 

  50. Smith JS, Eichholz KM, Shafizadeh S, Ogden AT, O’Toole JE, Fessler RG. Minimally invasive thoracic microendoscopic diskectomy: surgical technique and case series. World Neurosurg. 2013;80:421–7.

    Article  PubMed  Google Scholar 

  51. Perez-Cruet MJ, Foley KT, Isaacs RE, Rice-Wyllie L, Wellington R, Smith MM, Fessler RG. Microendoscopic lumbar discectomy: technical note. Neurosurgery. 2002;51:S129–36.

    PubMed  Google Scholar 

  52. Dasenbrock HH, Juraschek SP, Schultz LR, Witham TF, Sciubba DM, Wolinsky J-P, Gokaslan ZL, Bydon A. The efficacy of minimally invasive discectomy compared with open discectomy: a meta-analysis of prospective randomized controlled trials. J Neurosurg Spine. 2012;16:452–62.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Than KD, Wang AC, Etame AB, La Marca F, Park P. Postoperative management of incidental durotomy in minimally invasive lumbar spinal surgery. Minim Invasive Neurosurg. 2008;51:263–6.

    Article  CAS  PubMed  Google Scholar 

  54. Rasouli MR, Rahimi-Movaghar V, Shokraneh F, Moradi-Lakeh M, Chou R. Minimally invasive discectomy versus microdiscectomy/open discectomy for symptomatic lumbar disc herniation. Cochrane Database Syst Rev. 2014;20:CD010328.

    Google Scholar 

  55. Virk SS, Diwan A, Phillips FM, Sandhu H, Khan SN. What is the rate of revision discectomies after primary discectomy on a national scale. Clin Orthop Relat Res. 2017;33:273.

    Google Scholar 

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Correspondence to Gregory D. Lopez .

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Appendices

Quiz Questions

  1. 1.

    A 43-year-old female presents to the clinic with a 4-week history of low back pain that radiates to the left lower extremity. On examination, she has mildly decreased sensation over the dorsum of the foot and positive straight leg raise on the left side. MRI reveals a left-sided paracentral disc herniation at L4–L5. Which of the following is true regarding this patient’s clinical presentation and treatment options?

    1. (a)

      Nonoperative management with NSAIDS and physical therapy is effective for 50% of patients.

    2. (b)

      Surgical treatment is indicated in patients with diminished sensation.

    3. (c)

      Surgical treatment is equivalent to nonoperative management in terms of pain and function.

    4. (d)

      Good surgical outcome is associated with mainly back complaints.

    5. (e)

      The size of disc herniations typically decreases over time without surgical intervention.

  2. 2.

    A 25-year-old male presents with a 12-week history of low back pain and right leg pain. He has failed to improve with conservative therapies that include anti-inflammatory medications, physical therapy, and selective nerve root corticosteroid injections. Leg pain and paresthesias are localized to his buttock, lateral and posterior calf, and the dorsal aspect of his foot. His strength testing is graded at 4/5 for plantar-flexion and 4+/5 to ankle dorsiflexion. On flexion and extension radiographs, there is no evidence of spondylolisthesis. Sagittal and axial T2-weighted MR imagings reveal a right-sided paracentral disc herniation. Which of the following treatment modalities will allow the greatest improvement of physical functioning?

    1. (a)

      Observation alone

    2. (b)

      Physical therapy

    3. (c)

      Medical management with GABA analogs

    4. (d)

      Discectomy

    5. (e)

      Discectomy and instrumented fusion

  3. 3.

    A 29-year-old female reports a 10-day history of acute lower back pain with radiation into the left lower extremity. She denies any history of trauma and there are no systemic signs. On exam, she has a positive straight leg test at 30 degrees on the left side. Strength testing demonstrates mild weakness of the gluteus medius and weakness of the extensor hallucis longus of 4/5. On sensory exam, she describes decreased sensation along the lateral aspect of the calf and dorsum of the foot. Knee and ankle reflexes are intact and symmetrical. No obvious abnormalities are observed on plain lumbar radiographs. MRI scans show a left-sided paracentral disc hernation, most likely at what level?

    1. (a)

      L1–L2

    2. (b)

      L2–L3

    3. (c)

      L3–L4

    4. (d)

      L4–L5

    5. (e)

      L5–S1

Answers

  1. 1.

    e

  2. 2.

    d

  3. 3.

    d

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Louie, P.K., Lopez, G.D. (2019). Lumbar Herniated Nucleus Pulposus. In: Phillips, F., Lieberman, I., Polly Jr., D., Wang, M. (eds) Minimally Invasive Spine Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19007-1_34

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  • DOI: https://doi.org/10.1007/978-3-030-19007-1_34

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