Skip to main content

Emerging Trends in Nanobiosensor

  • Chapter
  • First Online:

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

Abstract

The rapid growth of nanotechnology in recent years has led to the development of new nanomaterials like carbon nanotubes, inorganic quantum dots, nanowires, graphene, and metal nanoparticles; with altered chemical, electrical, optical and physical properties. Surface functionalization capacity, novel signal amplification strategies, new electronic, optical and chemical properties of nanoscale materials have brought newer dimensions in biosensing, resulting in the development of nanobiosensors.

These nanobiosensors have the features like enhancement in sensitivity, specificity, and stability, and thus providing possibilities of quick detection systems for very small concentration of analytes. The field of nanobiosensors is multidisciplinary in nature involving the researchers from biological science, material science, electronics, medical science, physics, and chemistry to develop a variety of nanobiosensors. Recently, there has been great progress in the field of nanomaterial-based biosensors which is being integrated with microfluidics to design miniaturized and easy-to-use devices.

Fabrication of these ultrasensitive, low-cost, and highly selective nanobiosensors can provide benefits to both nanotechnology and biosensor in diverse areas like clinical diagnosis, environmental monitoring, food analysis, forensic sciences, and agricultural monitoring systems.

With the advancement in nanobiosensor technology, it is making the way toward applications like point-of-care (POC) devices, biochips, drug delivery system, and lab on a chip (LOC) involving array of nanobiosensors for rapid screening of multiple number of analytes.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Afsahi S, Lerner MB, Goldstein JM, Lee J, Tang X, Bagarozzi DA Jr, Goldsmith BR (2018) Novel graphene-based biosensor for early detection of Zika virus infection. Biosens Bioelectron 100:85–88

    Article  CAS  PubMed  Google Scholar 

  • Agnihotri N, Chowdhury AD, De A (2015) Non-enzymatic electrochemical detection of cholesterol using β-cyclodextrin functionalized graphene. Biosens Bioelectron 63:212–217

    Article  CAS  PubMed  Google Scholar 

  • Ali MA, Solanki PR, Srivastava S, Singh S, Agrawal VV, John R, Malhotra BD (2015) Protein functionalized carbon nanotubes-based smart lab-on-a-chip. ACS Appl Mater Interfaces 7(10):5837–5846

    Article  CAS  PubMed  Google Scholar 

  • Ali S, Hassan A, Hassan G, Eun CH, Bae J, Lee CH, Kim IJ (2018) Disposable all-printed electronic biosensor for instantaneous detection and classification of pathogens. Sci Rep 8(1):5920

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Aljabali AA, Hussein E, Aljumaili O, Al Zoubi M, Altrad B, Albatayneh K, Al-razaq MAA (2018) Rapid magnetic nanobiosensor for the detection of Serratia marcescens. In IOP Conference Series: Mater Sci Eng 305(1):012005

    Article  Google Scholar 

  • Altintas Z, Davis F, Scheller FW (2017) Applications of quantum dots in biosensors and diagnostics. Biosens Nanotechnol Appl Health Care Diagn 3:185–199

    Google Scholar 

  • Asnaashari M, Kenari RE, Farahmandfar R, Taghdisi SM, Abnous K (2018) Fluorescence quenching biosensor for acrylamide detection in food products based on double-stranded DNA and gold nanoparticles. Sens Actuators B Chem 265:339–345

    Article  CAS  Google Scholar 

  • Augustine R, Abraham AR, Kalarikkal N, Thomas S (2016) Monitoring and separation of food-borne pathogens using magnetic nanoparticles. In: Novel approaches of nanotechnology in food. Academic Press, UK, pp 271–312

    Chapter  Google Scholar 

  • Baldo S, Buccheri S, Ballo A, Camarda M, La Magna A, Castagna ME, Scalese S (2016) Carbon nanotube-based sensing devices for human Arginase-1 detection. Sens Bio-Sens Res 7:168–173

    Article  Google Scholar 

  • Bhattacharya M, Hong S, Lee D, Cui T, Goyal SM (2011) Carbon nanotube based sensors for the detection of viruses. Sens Actuators B Chem 155(1):67–74

    Article  CAS  Google Scholar 

  • Bhattacharyya D, Sarswat PK, Free ML (2017) Quantum dots and carbon dots based fluorescent sensors for TB biomarkers detection. Vacuum 146:606–613

    Article  CAS  Google Scholar 

  • Bolat G, Abaci S (2018) Non-enzymatic electrochemical sensing of malathion pesticide in tomato and apple samples based on gold nanoparticles-chitosan-ionic liquid hybrid nanocomposite. Sensors 18(3):773

    Article  CAS  PubMed Central  Google Scholar 

  • Cash KJ, Clark HA (2010) Nanosensors and nanomaterials for monitoring glucose in diabetes. Trends Mol Med 16(12):584–593

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Choi W, Lahiri I, Seelaboyina R, Kang YS (2010a) Synthesis of graphene and its applications: a review. Crit Rev Solid State Mater Sci 35(1):52–71

    Article  CAS  Google Scholar 

  • Choi YE, Kwak JW, Park JW (2010b) Nanotechnology for early cancer detection. Sensors 10(1):428–455

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chua CK, Pumera M (2013) Chemically modified graphenes as detectors in lab-on-chip device. Electroanalysis 25(4):945–950

    Article  CAS  Google Scholar 

  • Cihalova K, Hegerova D, Jimenez AM, Milosavljevic V, Kudr J, Skalickova S, Adam V (2017) Antibody-free detection of infectious bacteria using quantum dots-based barcode assay. J Pharm Biomed Anal 134:325–332

    Article  CAS  PubMed  Google Scholar 

  • Claussen J, Medintz IL (2012) Using nanotechnology to improve lab on a chip devices. Biochip Tissue Chip 2(4):1609–1614

    Google Scholar 

  • Dasgupta NP, Sun J, Liu C, Brittman S, Andrews SC, Lim J, Yang P (2014) 25th anniversary article: semiconductor nanowires–synthesis, characterization, and applications. Adv Mater 26(14):2137–2184

    Article  CAS  PubMed  Google Scholar 

  • Devi RV, Doble M, Verma RS (2015) Nanomaterials for early detection of cancer biomarker with special emphasis on gold nanoparticles in immunoassays/sensors. Biosens Bioelectron 68:688–698

    Article  CAS  Google Scholar 

  • Doria G, Conde J, Veigas B, Giestas L, Almeida C, Assunção M, Baptista PV (2012) Noble metal nanoparticles for biosensing applications. Sensors 12(2):1657–1687

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eftekhari-Sis B, Karaminejad S, Malekan F, Araghi HY, Akbari A (2017) CdSe quantum dots based Nano-biosensor for detection of 185delAG mutation in BRCA1 gene, responsible for breast Cancer. J Inorg Organomet Polym Mater 27(6):1911–1917

    Article  CAS  Google Scholar 

  • Frasco MF, Chaniotakis N (2009) Semiconductor quantum dots in chemical sensors and biosensors. Sensors 9(9):7266–7286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Geim AK, Novoselov KS (2007) The rise of graphene. Nat Mater 6(3):183–191

    Article  CAS  PubMed  Google Scholar 

  • Ghorab MA, Khalil MS (2015) Toxicological effects of organophosphates pesticides. Int J Environ Monit Anal 3:218–220

    CAS  Google Scholar 

  • Ghrera AS, Pandey CM, Ali MA, Malhotra BD (2015) Quantum dot-based microfluidic biosensor for cancer detection. Appl Phys Lett 106(19):193703

    Article  CAS  Google Scholar 

  • Han B, Zhang YL, Zhu L, Chen XH, Ma ZC, Zhang XL, Sun HB (2018) Direct laser scribing of AgNPs@ RGO biochip as a reusable SERS sensor for DNA detection. Sens Actuators B Chem 270:500–507

    Article  CAS  Google Scholar 

  • He S, Song B, Li D, Zhu C, Qi W, Wen Y, Fan C (2010) A graphene nanoprobe for rapid, sensitive, and multicolor fluorescent DNA analysis. Adv Funct Mater 20(3):453–459

    Article  CAS  Google Scholar 

  • Hutter E, Maysinger D (2013) Gold-nanoparticle-based biosensors for detection of enzyme activity. Trends Pharmacol Sci 34(9):497–507

    Article  CAS  PubMed  Google Scholar 

  • Ibrahim and Saeed (2013) Carbon nanotubes- properties and applications: a review. Carbon Lett 14(3):131–144

    Article  Google Scholar 

  • Iijima S (1991) Helical microtubules of graphitic carbon. Nature 354(6348):56–58

    Article  CAS  Google Scholar 

  • Jaishree V, Gupta PD (2012) Nanotechnology: a revolution in cancer diagnosis. Indian J Clin Biochem 27(3):214–220

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khan I, Saeed K, Khan I (2017) Nanoparticles: properties, applications and toxicities. Arab J Chem. https://doi.org/10.1016/j.arabjc.2017.05.011, in press

  • Kumar VV, Anthony SP (2014) Silver nanoparticles based selective colorimetric sensor for Cd2+, Hg2+ and Pb2+ ions: tuning sensitivity and selectivity using co-stabilizing agents. Sens Actuators B Chem 191:31–36

    Article  CAS  Google Scholar 

  • Kwak YH, Choi DS, Kim YN, Kim H, Yoon DH, Ahn SS, Seo S (2012) Flexible glucose sensor using CVD-grown graphene-based field effect transistor. Biosens Bioelectron 37(1):82–87

    Article  CAS  PubMed  Google Scholar 

  • Lee MH, Seong W, Lee S, Kim K (2012) Silicon nanowire based immunoassay for the detection of prostate cancer biomarkers. In Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference 1086–1088

    Google Scholar 

  • Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Toner M (2013) Magnetic barcode assay for genetic detection of pathogens. Nat Commun 4:1752

    Article  PubMed  CAS  Google Scholar 

  • Liu M, Jia C, Huang Y, Lou X, Yao S, Jin Q, Xiang J (2010) Highly sensitive protein detection using enzyme-labeled gold nanoparticle probes. Analyst 135(2):327–331

    Article  CAS  PubMed  Google Scholar 

  • Liu B, Sun Z, Zhang X, Liu J (2013) Mechanisms of DNA sensing on graphene oxide. Anal Chem 85(16):7987–7993

    Article  CAS  PubMed  Google Scholar 

  • Liu X, Yang W, Chen L, Jia J (2017) Three-dimensional copper foam supported CuO nanowire arrays: an efficient non-enzymatic glucose sensor. Electrochim Acta 235:519–526

    Article  CAS  Google Scholar 

  • Long Y, Zhang LF, Zhang Y, Zhang CY (2012) Single quantum dot based nanosensor for renin assay. Anal Chem 84(20):8846–8852

    Article  CAS  PubMed  Google Scholar 

  • Malik P, Katyal V, Malik V, Asatkar A, Inwati G, Mukherjee TK (2013) Nanobiosensors: concepts and variations. ISRN Nanomater 2013:1–9

    Article  CAS  Google Scholar 

  • Mandal D, Nunna BB, Zhuang S, Rakshit S, Lee ES (2017) Carbon nanotubes based biosensor for detection of cancer antigens (CA-125) under shear flow condition. Nano-Struct Nano-Objects 15:180–185

    Article  CAS  Google Scholar 

  • Marques I, Pinto da Costa J, Justino C, Santos P, Duarte K, Freitas A, Rocha-Santos T (2017) Carbon nanotube field effect transistor biosensor for the detection of toxins in seawater. Int J Environ Anal Chem 97(7):597–605

    Article  CAS  Google Scholar 

  • Melzer K, Bhatt VD, Jaworska E, Mittermeier R, Maksymiuk K, Michalska A, Lugli P (2016) Enzyme assays using sensor arrays based on ion-selective carbon nanotube field-effect transistors. Biosens Bioelectron 84:7–14

    Article  CAS  PubMed  Google Scholar 

  • Meshik X, Xu K, Dutta M, Stroscio MA (2014) Optical detection of lead and potassium ions using a quantum-dot-based aptamer nanosensor. IEEE Trans Nanobioscience 13(2):161–164

    Article  PubMed  Google Scholar 

  • Mohammed AM, Rahim RA, Ibraheem IJ, Loong FK, Hisham H, Hashim U, Al-Douri Y (2014) Application of gold nanoparticles for electrochemical DNA biosensor. J Nanomater 13:1–7

    Article  CAS  Google Scholar 

  • Mostafalu P, Sonkusale S (2015) A high-density nanowire electrode on paper for biomedical applications. RSC Adv 5(12):8680–8687

    Article  CAS  Google Scholar 

  • Nguyen NH, Duong TG, Pham NT, Dao TC, Pham TN (2015) Synthesis and application of quantum dots-based biosensor. Adv Nat Sci Nanosci Nanotechnol 6(1):015015

    Article  CAS  Google Scholar 

  • Nikam AP, Mukesh PR, Haudhary SP (2014) Nanoparticles—an overview. J Drug Deliv Ther 3:1121–1127

    CAS  Google Scholar 

  • Norouzi M, Zarei Ghobadi M, Golmimi M, Mozhgani SH, Ghourchian H, Rezaee SA (2017) Quantum Dot-Based Biosensor for the Detection of Human T-Lymphotropic Virus-1. Anal Lett 50(15):2402–2411

    Article  CAS  Google Scholar 

  • Patolsky F, Zheng G, Lieber CM (2006) Nanowire sensors for medicine and the life sciences. Future Med 1:51–65

    CAS  Google Scholar 

  • Paul B, Tiwari A (2015) A brief review on the application of gold nanoparticles as sensors in multi dimensional aspects. J Environ Sci Toxicol Food Technol 1(4):01–07

    CAS  Google Scholar 

  • Prasad R, Pandey R, Barman I (2016) Engineering tailored nanoparticles with microbes: quo vadis. WIREs Nanomed Nanobiotechnol 8:316–330. doi: 10.1002/wnan.1363

    PubMed  Google Scholar 

  • Quesada-González D, Merkoçi A (2018) Nanomaterial-based devices for point-of-care diagnostic applications. Chem Soc Rev 47(13):4697–4709

    Article  PubMed  Google Scholar 

  • Rahman SFA, Yusof NA, Hashim U, Hushiarian RMN, Hamidon MN, Fathil MFM (2016) Enhanced sensing of dengue virus DNA detection using O2 plasma treated-silicon nanowire based electrical biosensor. Anal Chim Acta 942:74–85

    Article  CAS  PubMed  Google Scholar 

  • Randviir EP, Brownson DA, Banks CE (2014) A decade of graphene research: production, applications and outlook. Mater Today 17(9):426–432

    Article  CAS  Google Scholar 

  • Rasheed PA, Sandhyarani N (2014) Graphene-DNA electrochemical sensor for the sensitive detection of BRCA1 gene. Sens Actuators B Chem 204:777–782

    Article  CAS  Google Scholar 

  • Rocha-Santos TAP (2014) Sensors and biosensors based on magnetic nanoparticles. TrAC Trends Anal Chem 62:28–36

    Article  CAS  Google Scholar 

  • Salvati E, Stellacci F, Krol S (2015) Nanosensors for early cancer detection and for therapeutic drug monitoring. Nanomedicine 10(23):3495–3512

    Article  CAS  PubMed  Google Scholar 

  • Salvetat JP, Bonard JM, Thomson NH, Kulik AJ, Forro L, Benoit W, Zuppiroli L (1999) Mechanical properties of carbon nanotubes. Appl Phys A Mater Sci Process 69(3):255–260

    Article  CAS  Google Scholar 

  • Shelby T, Sulthana S, McAfee J, Banerjee T, Santra S (2017) Foodborne pathogen screening using magneto-fluorescent nanosensor: rapid detection of E. Coli O157: H7. J Vis Exp (JoVE) 127:1–7

    Google Scholar 

  • Shen F, Wang J, Xu Z, Wu Y, Chen Q, Li X, Zhu T (2012) Rapid flu diagnosis using silicon nanowire sensor. Nano Lett 12(7):3722–3730

    Article  CAS  PubMed  Google Scholar 

  • Sirivisoot S, Pareta RA (2012) Orthopedic carbon nanotube biosensors for controlled drug delivery. In: Nanomedicine. Woodhead Publishing, UK, pp 149–179

    Chapter  Google Scholar 

  • Song D, Li Y, Lu X, Sun M, Liu H, Yu G, Gao F (2017) Palladium-copper nanowires-based biosensor for the ultrasensitive detection of organophosphate pesticides. Anal Chim Acta 982:168–175

    Article  CAS  PubMed  Google Scholar 

  • Suvarnaphaet P, Pechprasarn S (2017) Graphene-based materials for biosensors: a review. Sensors 17(10):2161

    Article  CAS  PubMed Central  Google Scholar 

  • Syedmoradi L, Daneshpour M, Alvandipour M, Gomez FA, Hajghassem H, Omidfar K (2017) Point of care testing: the impact of nanotechnology. Biosens Bioelectron 87:373–387

    Article  CAS  PubMed  Google Scholar 

  • Tan J, Hao B, Wang C, Ren Y, Hao H, Yang R (2016) A gold nanoparticle-enhanced surface plasmon resonance aptasensor for the detection of 2, 4, 6-trinitrotoluene. J Forensic Sci Med 2(4):195

    Article  Google Scholar 

  • Thapa A, Soares AC, Soares JC, Awan IT, Volpati D, Melendez ME, Oliveira ON Jr (2017) Carbon nanotube matrix for highly sensitive biosensors to detect pancreatic cancer biomarker CA19-9. ACS Appl Mater Interfaces 9(31):25878–25886

    Article  CAS  PubMed  Google Scholar 

  • Varshney K (2014) Carbon nanotubes: a review on synthesis, properties and applications. Int J Eng Res 2(4):660–677

    Google Scholar 

  • Rao TVN, Sukruthi SG, Raj G (2012) Biochip Technology- A gigantic Innovation. International Int J Emerg Technol Adv Eng 2:129–135

    Google Scholar 

  • Wang R, Ruan C, Kanayeva D, Lassiter K, Li Y (2008) TiO2 nanowire bundle microelectrode based impedance immunosensor for rapid and sensitive detection of Listeria monocytogenes. Nano Lett 8(9):2625–2631

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Zhang Y, Li H, Du B, Ma H, Wu D, Wei Q (2013) A silver–palladium alloy nanoparticle-based electrochemical biosensor for simultaneous detection of ractopamine, clenbuterol and salbutamol. Biosens Bioelectron 49:14–19

    Article  PubMed  CAS  Google Scholar 

  • Wang H, Sugiarto S, Li T, Ang WH, Lee C, Pastorin G (2016) Advances in nanomaterials and their applications in point of care (POC) devices for the diagnosis of infectious diseases. Biotechnol Adv 34(8):1275–1288

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Wen L, Qiu L, Wu Y, Hu X, Zhang X (2017) Aptamer-modified semiconductor quantum dots for biosensing applications. Sensors 17(8):1736

    Article  CAS  PubMed Central  Google Scholar 

  • Xia N, Chen Z, Liu Y, Ren H, Liu L (2017) Peptide aptamer-based biosensor for the detection of human chorionic gonadotropin by converting silver nanoparticles-based colorimetric assay into sensitive electrochemical analysis. Sens Actuators B Chem 243:784–791

    Article  CAS  Google Scholar 

  • Xu H, Aguilar ZP, Wang A (2010) Quantum Dot-based Sensors for Proteins. ECS Trans 25(31):1–8

    Article  CAS  Google Scholar 

  • Yang M, Sun S, Kostov Y, Rasooly A (2010) Lab-on-a-chip for carbon nanotubes based immunoassay detection of Staphylococcal Enterotoxin B (SEB). Lab Chip 10(8):1011–1017

    Article  CAS  PubMed  Google Scholar 

  • Yang J, Strickler JR, Gunasekaran S (2012) Indium tin oxide-coated glass modified with reduced graphene oxide sheets and gold nanoparticles as disposable working electrodes for dopamine sensing in meat samples. Nanoscale 4(15):4594–4602

    Article  CAS  PubMed  Google Scholar 

  • Yue Z, Lisdat F, Parak WJ, Hickey SG, Tu L, Sabir N, Bigall NC (2013) Quantum-dot-based photoelectrochemical sensors for chemical and biological detection. ACS Appl Mater Interfaces 5(8):2800–2814

    Article  CAS  PubMed  Google Scholar 

  • Zeng X, Gao H, Pan D, Sun Y, Cao J, Wu Z, Pan Z (2015) Highly sensitive electrochemical determination of alfatoxin B1 using quantum dots-assembled amplification labels. Sensors 15(8):20648–20658

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang M, Liao C, Mak CH, You P, Mak CL, Yan F (2015) Highly sensitive glucose sensors based on enzyme-modified whole-graphene solution-gated transistors. Sci Rep 5:8311

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhu Y, Hao Y, Adogla EA, Yan J, Li D, Xu K, Wang Q, Hone J, Lin Q (2016) A graphene-based affinity nanosensor for detection of low-charge and low-molecular-weight molecules. Nanoscale 8(11):5815–5819

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kumari, V., Rastogi, S., Sharma, V. (2019). Emerging Trends in Nanobiosensor. In: Prasad, R., Kumar, V., Kumar, M., Choudhary, D. (eds) Nanobiotechnology in Bioformulations. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-17061-5_18

Download citation

Publish with us

Policies and ethics