Skip to main content
SpringerLink
Log in

Collagenase Model of Intracerebral Hemorrhage in Rats

  • Chapter
  • First Online:
Animal Models of Acute Neurological Injury

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Intracerebral hemorrhage is the most devastating stroke subtype with a high mortality rate. Currently there are no clinically approved therapeutic strategies decreasing mortality and improving quality of life for the ICH patients. Preclinical models mimicking human pathophysiology of intracerebral hemorrhage are necessary to evaluate the potential effectiveness of new therapeutic approaches. Rodents are the most commonly used species for modeling stroke, including hemorrhagic stroke. This chapter focuses on describing the “collagenase” model of intracerebral hemorrhage on rats.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Qureshi AI, Suri MF, Nasar A, et al. Changes in cost and outcome among US patients with stroke hospitalized in 1990 to 1991 and those hospitalized in 2000 to 2001. Stroke. 2007;38(7):2180–4.

    Article  Google Scholar 

  2. Qureshi AI, Mendelow AD, Hanley DF. Intracerebral haemorrhage. Lancet. 2009;373(9675):1632–44.

    Article  Google Scholar 

  3. Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med. 2001;344(19):1450–60.

    Article  CAS  Google Scholar 

  4. Steiner T, Rosand J, Diringer M. Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions. Stroke. 2006;37(1):256–62.

    Article  CAS  Google Scholar 

  5. Elijovich L, Patel PV, Hemphill JC III. Intracerebral hemorrhage. Semin Neurol. 2008;28(5):657–67.

    Article  Google Scholar 

  6. Rosenberg GA, Mun-Bryce S, Wesley M, Kornfeld M. Collagenase-induced intracerebral hemorrhage in rats. Stroke. 1990;21(5):801–7.

    Article  CAS  Google Scholar 

  7. Kazui S, Naritomi H, Yamamoto H, Sawada T, Yamaguchi T. Enlargement of spontaneous intracerebral hemorrhage. Incidence and time course. Stroke. 1996;27(10):1783–7.

    Article  CAS  Google Scholar 

  8. Sang LY, Liang YX, Li Y, et al. A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage. Nanomedicine. 2015;11(3):611–20.

    Article  CAS  Google Scholar 

  9. Zhao X, Sun G, Zhang J, Ting SM, Gonzales N, Aronowski J. Dimethyl fumarate protects brain from damage produced by intracerebral hemorrhage by mechanism involving Nrf2. Stroke. 2015;46(7):1923–8.

    Article  CAS  Google Scholar 

  10. Manaenko A, Fathali N, Chen H, et al. Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage. Neurochem Int. 2010;57(7):844–50.

    Article  CAS  Google Scholar 

  11. Manaenko A, Fathali N, Khatibi NH, et al. Arginine-vasopressin V1a receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injury. Neurochem Int. 2011;58(4):542–8.

    Article  CAS  Google Scholar 

  12. Manaenko A, Lekic T, Ma Q, Zhang JH, Tang J. Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Crit Care Med. 2013;41(5):1266–75.

    Article  CAS  Google Scholar 

  13. Chen M, Li X, Zhang X, et al. The inhibitory effect of mesenchymal stem cell on blood-brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6. J Neuroinflammation. 2015;12:61.

    Article  Google Scholar 

  14. Zhang Y, Yi B, Ma J, et al. Quercetin promotes neuronal and behavioral recovery by suppressing inflammatory response and apoptosis in a rat model of intracerebral hemorrhage. Neurochem Res. 2015;40(1):195–203.

    Article  Google Scholar 

  15. Hartman RE, Rojas H, Tang J, Zhang J. Long-term behavioral characterization of a rat model of intracerebral hemorrhage. Acta Neurochir Suppl. 2008;105:125–6.

    Article  CAS  Google Scholar 

  16. Geng X, Ren C, Wang T, et al. Effect of remote ischemic postconditioning on an intracerebral hemorrhage stroke model in rats. Neurol Res. 2012;34(2):143–8.

    Article  CAS  Google Scholar 

  17. Wu G, Bao X, Xi G, Keep RF, Thompson BG, Hua Y. Brain injury after intracerebral hemorrhage in spontaneously hypertensive rats. J Neurosurg. 2011 Jun;114(6):1805–11.

    Article  CAS  Google Scholar 

  18. Hua Y, Schallert T, Keep RF, Wu J, Hoff JT, Xi G. Behavioral tests after intracerebral hemorrhage in the rat. Stroke. 2002 Oct;33(10):2478–84.

    Article  Google Scholar 

  19. Nakamura T, Xi G, Hua Y, Schallert T, Hoff JT, Keep RF. Intracerebral hemorrhage in mice: model characterization and application for genetically modified mice. J Cereb Blood Flow Metab. 2004 May;24(5):487–94.

    Article  Google Scholar 

  20. MacLellan CL, Silasi G, Poon CC, et al. Intracerebral hemorrhage models in rat: comparing collagenase to blood infusion. J Cereb Blood Flow Metab. 2008;28(3):516–25.

    Article  CAS  Google Scholar 

  21. Lekic T, Tang J, Zhang JH. Rat model of intracerebellar hemorrhage. Acta Neurochir Suppl. 2008;105:131–4.

    Article  CAS  Google Scholar 

  22. Matsushita K, Meng W, Wang X, et al. Evidence for apoptosis after intercerebral hemorrhage in rat striatum. J Cereb Blood Flow Metab. 2000;20(2):396–404.

    Article  CAS  Google Scholar 

  23. Karwacki Z, Kowianski P, Dziewatkowski J, et al. Apoptosis in the course of experimental intracerebral haemorrhage in the rat. Folia Morphol (Warsz). 2005;64(4):248–52.

    CAS  Google Scholar 

  24. Sun H, Li L, Zhou F, et al. The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats. J Mol Histol. 2013;44(4):369–79.

    Article  CAS  Google Scholar 

  25. Kleinig TJ, Helps SC, Ghabriel MN, et al. Hemoglobin crystals: a pro-inflammatory potential confounder of rat experimental intracerebral hemorrhage. Brain Res. 2009;1287:164–72.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA

    Anatol Manaenko, Derek Nowrangi, Jiping Tang & John H. Zhang

  2. Departments of Anesthesiology and Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA

    Reis Cesar

Authors
  1. Anatol Manaenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Derek Nowrangi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Reis Cesar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jiping Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. John H. Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to John H. Zhang .

Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jun Chen

  2. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Zao C. Xu

  3. Indiana University School of Medicine, SNRI SCBIRG, Indianapolis, IN, USA

    Xiao Ming Xu

  4. Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, CA, USA

    John H. Zhang

Electronic Supplementary Material

(MOV 94786 kb)

(MOV 65412 kb)

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Manaenko, A., Nowrangi, D., Cesar, R., Tang, J., Zhang, J.H. (2019). Collagenase Model of Intracerebral Hemorrhage in Rats. In: Chen, J., Xu, Z., Xu, X., Zhang, J. (eds) Animal Models of Acute Neurological Injury. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-030-16082-1_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-16082-1_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16080-7

  • Online ISBN: 978-3-030-16082-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation