Abstract
Local recurrence (LR) is the return of ipsilateral breast disease, while locorregional relapse is the resurgence of neoplasia in the breast and/or drainage chains after conservative surgery or mastectomy for the treatment of cancer. The psychological impact may be significant for women, since it means a new surgical approach, new alternatives of systemic treatment, causing a feeling of intractability of the disease and decrease of the possibility of cure. LR rates have been decreasing over time: earlier diagnosis, evolution of imaging and pathological analysis, and the addition of adjuvant treatment (especially systemic) are factors related to better locorregional control.
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Braunstein LZ, Taghian AG, Niemierko A, et al. Breast-cancer subtype, age, and lymph node status as predictors of local recurrence following breast-conserving therapy. Breast Cancer Res Treat. 2017;161(1):173. The risk of recurrence after conservative surgery is greater in non-luminal subtypes, young patients and number of compromised lymph nodes, which are similar to post-mastectomy risks.
Hattangadi-Gluth JA, Wo JY, Nguyen PL, et al. Basal subtype of invasive breast cancer is associated with a higher risk of true recurrence after conventional breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2012;82(3):1185–91. Patients with baseline histological subtype and HER2 presented higher rates of local recurrence after surgical treatment. Chemotherapy and target therapy act concurrently to decrease local recurrence.
Huang E, Buchholz TA, Meric F, et al. Classifying local disease recurrences after breast conservation therapy based on location and histology: new primary tumors have more favorable outcomes than true local disease recurrences. Cancer. 2002;95(10):2059. Patients with a new tumor have better survival rates when compared to patients with true recurrence; however, they present a higher chance of contralateral carcinoma. Patients with true recurrence have a greater chance of distant metastasis.
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BBSG – Brazilian Breast Study Group. (2019). Local Recurrence After Surgery. In: Novita, G., Frasson, A., Millen, E., Zerwes, F., Cavalcante, F. (eds) Breast Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-13636-9_54
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DOI: https://doi.org/10.1007/978-3-030-13636-9_54
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