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Pragmatic Trials: Solving the Dilemma of Psychiatric Nonadherence

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Abstract

This chapter aims to describe pragmatic clinical trials and how they differ from traditional explanatory trials in terms of validity, design, and setting. We discuss the defining principles of pragmatic clinical trials and how they are vital in moving psychiatric research forward to the development of better-informed treatment choices for patients and providers. We describe the Patient-Centered Outcomes Research Institute (PCORI), their tenets, and how they are a large funding source of pragmatic trials and clinical effectiveness research. We highlight two pragmatic clinical trials in the field of child psychiatry as a way of showcasing how pragmatic clinical trials can help in shared decision-making and solve the dilemma of psychiatric nonadherence.

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Author information

Authors and Affiliations

  1. Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY, USA

    Claudine Higdon & Rebecca M. Eichenbaum

  2. Child and Adolescent Outpatient Psychiatry Department, Northwell Health, Zucker Hillside Hospital, Glen Oaks, NY, USA

    Claudine Higdon

  3. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA

    Rebecca M. Eichenbaum

  4. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Melissa P. DelBello

Authors
  1. Claudine Higdon
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  2. Rebecca M. Eichenbaum
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  3. Melissa P. DelBello
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Corresponding author

Correspondence to Claudine Higdon .

Editor information

Editors and Affiliations

  1. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA

    Victor Fornari

  2. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA

    Ida Dancyger

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Higdon, C., Eichenbaum, R.M., DelBello, M.P. (2019). Pragmatic Trials: Solving the Dilemma of Psychiatric Nonadherence. In: Fornari, V., Dancyger, I. (eds) Psychiatric Nonadherence. Springer, Cham. https://doi.org/10.1007/978-3-030-12665-0_13

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  • DOI: https://doi.org/10.1007/978-3-030-12665-0_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-12664-3

  • Online ISBN: 978-3-030-12665-0

  • eBook Packages: MedicineMedicine (R0)

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