Abstract
The past decade has seen a dramatic increase in the use of neuromodulation to treat chronic pain. Peripheral nerve stimulation (PNS) is one of the most diverse and rapidly expanding areas of neuromodulation. The first implantable PNS systems were surgically placed with careful dissection and fascial grafting; however, it has become commonplace to use percutaneous methods. The ease of this minimally invasive percutaneous approach leads to a broader adoption of the therapy and expanded PNS treatments for chronic pain. The first percutaneous peripheral nerve stimulators were reported in 1999. Cylindrical leads were implanted to stimulate the greater occipital nerve allowing successful treatment of intractable headaches. The application of PNS has expanded to treat neuropathic, visceral, cardiac, abdominal, low back, and facial pain. New technologies that allow easier and safer electrode placement are expected to further expand the uses of PNS. Chronic primary headaches are widespread disorders which tremendously reduce quality of life and can be very resistant to pharmacological treatments. Neuromodulation procedures have been shown to successfully target not only these central headache syndromes but also pain pathology in painful peripheral structures.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsRecommended Reading
Althaus J. A treatise on medical electricity: theoretical and practical and its use in the treatment of paralysis, neuralgia, and other diseases. London: Longmans; 1873.
Bartsch T, Goadsby PJ. Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input. Brain. 2002;125(Pt 7):1496–509.
Bartsch T, Goadsby PJ. Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater. Brain. 2003;126(Pt 8):1801–13.
Beck E, Sieber WJ, Trejo R. Management of cluster headache. Am Fam Physician. 2005;71(4):717–24.
Bittar RG, Teddy PJ. Peripheral neuromodulation for pain. J Clin Neurosci. 2009;16(10):1259–61.
Burns B, Watkins L, Goadsby PJ. Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients. Lancet. 2007;369(9567):1099–106.
Campbell JN, Long DM. Peripheral nerve stimulation in the treatment of intractable pain. J Neurosurg. 1976;45(6):692–9.
Campbell CM, Jamison RN, Edwards RR. Psychological screening/phenotyping as predictors for spinal cord stimulation. Curr Pain Headache Rep. 2013;17(1):307.
Deer TR, Mekhail N, Provenzano D, et al. The appropriate use of neurostimulation: avoidance and treatment of complications of neurostimulation therapies for the treatment of chronic pain. Neuromodulation Appropriateness Consensus Committee. Neuromodulation. 2014;17(6):571–97; discussion 597–598.
Dodick DW, Silberstein SD, Reed KL, et al. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: long-term results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia. 2015;35(4):344–58.
Eldabe S, Buchser E, Duarte RV. Complications of spinal cord stimulation and peripheral nerve stimulation techniques: a review of the literature. Pain Med. 2016;17(2):325–36.
Falowski S, Wang D, Sabesan A, Sharan A. Occipital nerve stimulator systems: review of complications and surgical techniques. Neuromodulation. 2010;13(2):121–5.
Fumal A, Schoenen J. Current migraine management - patient acceptability and future approaches. Neuropsychiatr Dis Treat. 2008;4(6):1043–57.
Goadsby PJ, Knight YE, Hoskin KL. Stimulation of the greater occipital nerve increases metabolic activity in the trigeminal nucleus caudalis and cervical dorsal horn of the cat. Pain. 1997;73(1):23–8.
Goadsby PJ, Schoenen J, Ferrari MD, Silberstein SD, Dodick D. Towards a definition of intractable headache for use in clinical practice and trials. Cephalalgia. 2006;26(9):1168–70.
Goroszeniuk T, Pang D. Peripheral neuromodulation: a review. Curr Pain Headache Rep. 2014;18(5):412.
Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.
Hoskin KL, Kaube H, Goadsby PJ. Sumatriptan can inhibit trigeminal afferents by an exclusively neural mechanism. Brain. 1996;119(Pt 5):1419–28.
Huntoon MA, Burgher AH. Ultrasound-guided permanent implantation of peripheral nerve stimulation (PNS) system for neuropathic pain of the extremities: original cases and outcomes. Pain Med. 2009;10(8):1369–77.
Huntoon MA, Huntoon EA, Obray JB, Lamer TJ. Feasibility of ultrasound-guided percutaneous placement of peripheral nerve stimulation electrodes in a cadaver model: part one, lower extremity. Reg Anesth Pain Med. 2008a;33(6):551–7.
Huntoon MA, Hoelzer BC, Burgher AH, Hurdle MFB, Huntoon EA. Feasibility of ultrasound-guided percutaneous placement of peripheral nerve stimulation electrodes and anchoring during simulated movement: part two, upper extremity. Reg Anesth Pain Med. 2008b;33(6):558–65.
Johnstone CSH, Sundaraj R. Occipital nerve stimulation for the treatment of occipital neuralgia-eight case studies. Neuromodulation. 2006;9(1):41–7.
Kapural L, Mekhail N, Hayek SM, Stanton-Hicks M, Malak O. Occipital nerve electrical stimulation via the midline approach and subcutaneous surgical leads for treatment of severe occipital neuralgia: a pilot study. Anesth Analg. 2005;101(1):171–4, table of contents.
Kaube H, Keay KA, Hoskin KL, Bandler R, Goadsby PJ. Expression of c-Fos-like immunoreactivity in the caudal medulla and upper cervical spinal cord following stimulation of the superior sagittal sinus in the cat. Brain Res. 1993;629(1):95–102.
Kidd BL, Urban LA. Mechanisms of inflammatory pain. Br J Anaesth. 2001;87(1):3–11.
Lee PB, Horazeck C, Nahm FS, Huh BK. Peripheral nerve stimulation for the treatment of chronic intractable headaches: long-term efficacy and safety study. Pain Physician. 2015;18(5):505–16.
Magis D, Allena M, Bolla M, De Pasqua V, Remacle J-M, Schoenen J. Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol. 2007;6(4):314–21.
Magis D, Gerardy P-Y, Remacle J-M, Schoenen J. Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. Headache. 2011;51(8):1191–201.
Magown P, Garcia R, Beauprie I, Mendez IM. Occipital nerve stimulation for intractable occipital neuralgia: an open surgical technique. Clin Neurosurg. 2009;56:119–24.
Matharu MS, Bartsch T, Ward N, Frackowiak RSJ, Weiner R, Goadsby PJ. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain. 2004;127(Pt 1):220–30.
Mathew NT. Transformed migraine, analgesic rebound, and other chronic daily headaches. Neurol Clin. 1997;15(1):167–86.
Nesbitt AD, Goadsby PJ. Cluster headache. BMJ. 2012;344:e2407.
Paemeleire K, Van Buyten J-P, Van Buynder M, et al. Phenotype of patients responsive to occipital nerve stimulation for refractory head pain. Cephalalgia. 2010;30(6):662–73.
Papuć E, Rejdak K. The role of neurostimulation in the treatment of neuropathic pain. Ann Agric Environ Med. 2013;Spec no. 1:14–7.
Petersen EA, Slavin KV. Peripheral nerve/field stimulation for chronic pain. Neurosurg Clin N Am. 2014;25(4):789–97.
Popeney CA, Aló KM. Peripheral neurostimulation for the treatment of chronic, disabling transformed migraine. Headache. 2003;43(4):369–75.
Reed KL, Black SB, Banta CJ 2nd, Will KR. Combined occipital and supraorbital neurostimulation for the treatment of chronic migraine headaches: initial experience. Cephalalgia. 2010;30(3):260–71.
Saper JR. Daily chronic headache. Compr Ther. 1992;18(5):6–10.
Schwedt TJ, Dodick DW, Hentz J, Trentman TL, Zimmerman RS. Occipital nerve stimulation for chronic headache--long-term safety and efficacy. Cephalalgia. 2007;27(2):153–7.
Siberstein SD, Lipton RB, Solomon S, Mathew NT. Classification of daily and near-daily headaches: proposed revisions to the IHS criteria. Headache. 1994;34(1):1–7.
Silberstein SD, Silberstein JR. Chronic daily headache: long-term prognosis following inpatient treatment with repetitive IV DHE. Headache. 1992;32(9):439–45.
Silberstein SD, Dodick DW, Saper J, et al. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia. 2012;32(16):1165–79.
Slavin KV, Nersesyan H, Wess C. Peripheral neurostimulation for treatment of intractable occipital neuralgia. Neurosurgery. 2006;58(1):112–9; discussion 112–119.
Soin A, Fang Z-P, Velasco J. Peripheral neuromodulation to treat postamputation pain. Prog Neurol Surg. 2015;29:158–67.
Stevanato G, Devigili G, Eleopra R, et al. Chronic post-traumatic neuropathic pain of brachial plexus and upper limb: a new technique of peripheral nerve stimulation. Neurosurg Rev. 2014;37(3):473–9; discussion 479–480.
Stovner L, Hagen K, Jensen R, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007;27(3):193–210.
Tavanaiepour D, Levy RM. Peripheral neuromodulation for treatment of chronic migraine headache. Neurosurg Clin N Am. 2014;25(1):11–4.
Tsoucalas G, Karamanou M, Lymperi M, Gennimata V, Androutsos G. The “torpedo” effect in medicine. Int Marit Health. 2014;65(2):65–7.
Weaver-Agostoni J. Cluster headache. Am Fam Physician. 2013;88(2):122–8.
Weiner RL, Reed KL. Peripheral neurostimulation for control of intractable occipital neuralgia. Neuromodulation. 1999;2(3):217–21.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Campos, L.W. (2019). Occipital Nerve Stimulation. In: Deer, T., Pope, J., Lamer, T., Provenzano, D. (eds) Deer's Treatment of Pain. Springer, Cham. https://doi.org/10.1007/978-3-030-12281-2_63
Download citation
DOI: https://doi.org/10.1007/978-3-030-12281-2_63
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-12280-5
Online ISBN: 978-3-030-12281-2
eBook Packages: MedicineMedicine (R0)