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Molecular and Cell Biology of Cancer pp 97–116Cite as

Cell Metabolism in Cancer: An Energetic Switch

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Abstract

Over the years, cancer has been viewed as a genetic disorder caused by an unbalance in proliferation. However, recent evidence has suggested that cancer is also a metabolic disease. Growing tumors rewire their metabolic programs to meet and even exceed the bioenergetic and biosynthetic demands of continuous cell growth. The metabolic profile typically seen in cancer cells includes increased consumption of glucose and glutamine, high levels of glycolysis, changes in the use of metabolic enzyme isoforms, and an enormous amounts of lactate secretion. Reinforcing the idea that cancer is, indeed, a metabolic disease, oncogenes and tumor suppressors have been shown to have roles in cancer-associated changes in metabolism as well. This chapter discusses recent research in the field of cancer metabolism, looking to find answers for the following questions: What characterizes the metabolic signature of a cancer cell? Why do cancer cells shift their metabolism? Are these changes a consequence or a driver of cancer progression? Can cancer metabolism be targeted to benefit patients?

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  1. FairJourney Biologics, Porto, Portugal

    Inês Pimenta de Castro

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  1. Inês Pimenta de Castro
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  1. Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, Portugal

    Rita Fior

  2. Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal

    Rita Zilhão

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de Castro, I.P. (2019). Cell Metabolism in Cancer: An Energetic Switch. In: Fior, R., Zilhão, R. (eds) Molecular and Cell Biology of Cancer. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-11812-9_6

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